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Paper · 24909170

Ligand-associated ERBB2/3 activation confers acquired resistance to FGFR inhibition in FGFR3-dependent cancer cells.

Wang J and 8 others. Oncogene, 2015. Cited by 63 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Ligand-associated ERBB2/3 activation confers acquired resistance to FGFR inhibition in FGFR3-dependent cancer cells. Papers, record 24909170. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/24909170

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Ligand-associated ERBB2/3 activation confers acquired resistance to FGFR inhibition in FGFR3-dependent cancer cells.
PubMed
Journal
Oncogene
PubMed
Year
2015
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.
PubMed
Citations, by iCite
63
iCite
Relative citation ratio, by iCite
1.71
iCite
Revised in PubMed
2026-01-28
PubMed

Authors9

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Wang JJ
2Mikse OO
3Liao RGR G
4Li YY
5Tan LL
6Janne PAP A
7Gray NSN S
8Wong KKK-k
9Hammerman PSP S

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Drug Resistance, NeoplasmMajor topic
Epithelial-Mesenchymal TransitionMajor topic
ImidazolesMajor topic
Phenylurea CompoundsMajor topic
Protein Kinase InhibitorsMajor topic
PyridazinesMajor topic
PyrimidinesMajor topic
Erb-b2 Receptor Tyrosine KinasesMajor topic
Receptor, ErbB-3Major topic
Receptor, Fibroblast Growth Factor, Type 3Major topic
Cell Line, Tumor
Enzyme Activation
Humans

Source PubMed

Grants4

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
K08 CA163677NCI NIH HHSUnited StatesK08CA163677PubMed and NIHNIH RePORTER
P01 CA154303NCI NIH HHSUnited StatesP01CA154303PubMed and NIHNIH RePORTER
R01 CA140594NCI NIH HHSUnited StatesR01CA140594PubMed and NIHNIH RePORTER
R01 CA166480NCI NIH HHSUnited StatesR01CA166480PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References45

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
118,381,441FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival.Cancer Res2008https://conductscience.org/library/papers/18381441PubMed
222,837,387Transforming fusions of FGFR and TACC genes in human glioblastoma.Science2012https://conductscience.org/library/papers/22837387PubMed
322,874,768Rescue screens with secreted proteins reveal compensatory potential of receptor tyrosine kinases in driving cancer growth.Cancer Discov2012https://conductscience.org/library/papers/22874768PubMed
412,461,689Novel fibroblast growth factor receptor 3 (FGFR3) mutations in bladder cancer previously identified in non-lethal skeletal disorders.Eur J Hum Genet2002https://conductscience.org/library/papers/12461689PubMed
523,661,334Identification of recurrent FGFR3 fusion genes in lung cancer through kinome-centred RNA sequencing.J Pathol2013https://conductscience.org/library/papers/23661334PubMed
616,564,017A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen.Cell2006https://conductscience.org/library/papers/16564017PubMed
720,101,236Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets.Oncogene2010https://conductscience.org/library/papers/20101236PubMed
822,869,148Tumour cell responses to new fibroblast growth factor receptor tyrosine kinase inhibitors and identification of a gatekeeper mutation in FGFR3 as a mechanism of acquired resistance.Oncogene2013https://conductscience.org/library/papers/22869148PubMed
923,558,953Identification of targetable FGFR gene fusions in diverse cancers.Cancer Discov2013https://conductscience.org/library/papers/23558953PubMed
1023,002,168FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor.Cancer Discov2012https://conductscience.org/library/papers/23002168PubMed

1 to 10 of 45

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Cited by40

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 63 citations.

PMIDTitleJournalYearIn PapersSource
42,351,126
Integrative multi-omics and single-cell analysis identifies EGFR pathway activation and metabolic reprogramming as potential synthetic lethal vulnerabilities in resistance to the FGFR inhibitor AZD4547.
J Transl Med2026https://conductscience.org/library/papers/42351126PubMed
39,690,380FGFR-Altered Urothelial Carcinoma: Resistance Mechanisms and Therapeutic Strategies.Target Oncol2025https://conductscience.org/library/papers/39690380PubMed
39,410,541Integrating Genetic Alterations and Histopathological Features for Enhanced Risk Stratification in Non-Muscle-Invasive Bladder Cancer.Diagnostics (Basel)2024https://conductscience.org/library/papers/39410541PubMed
39,031,286The roles of FGFR3 and c-MYC in urothelial bladder cancer.Discov Oncol2024https://conductscience.org/library/papers/39031286PubMed
38,831,455Targeting FGFR for cancer therapy.J Hematol Oncol2024https://conductscience.org/library/papers/38831455PubMed
38,525,398The Application of Artificial Intelligence and Drug Repositioning for the Identification of Fibroblast Growth Factor Receptor Inhibitors: A Review.Adv Biomed Res2024https://conductscience.org/library/papers/38525398PubMed
38,175,774Adipocyte Precursor-Derived NRG1 Promotes Resistance to FGFR Inhibition in Urothelial Carcinoma.Cancer Res2024https://conductscience.org/library/papers/38175774PubMed
37,681,152Fibroblast growth factor receptors as targets for anticancer therapy in cholangiocarcinomas and urothelial carcinomas.Heliyon2023https://conductscience.org/library/papers/37681152PubMed
36,611,892Investigation of Rare Non-Coding Variants in Familial Multiple Myeloma.Cells2022https://conductscience.org/library/papers/36611892PubMed
36,455,506Targeting the FGF/FGFR axis and its co-alteration allies.ESMO Open2022https://conductscience.org/library/papers/36455506PubMed

1 to 10 of 40

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Genes34

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
AKT1207PubTator's text mininghttps://conductscience.org/library/genes/207NCBI Gene
AREG374PubTator's text mininghttps://conductscience.org/library/genes/374NCBI Gene
BRAF673PubTator's text mininghttps://conductscience.org/library/genes/673NCBI Gene
BTC685PubTator's text mininghttps://conductscience.org/library/genes/685NCBI Gene
CDH1999PubTator's text mininghttps://conductscience.org/library/genes/999NCBI Gene
CDH21,000PubTator's text mininghttps://conductscience.org/library/genes/1000NCBI Gene
EGF1,950PubTator's text mininghttps://conductscience.org/library/genes/1950NCBI Gene
EGFR1,956PubTator's text mininghttps://conductscience.org/library/genes/1956NCBI Gene
ERBB22,064PubTator's text mininghttps://conductscience.org/library/genes/2064NCBI Gene
ERBB32,065PubTator's text mininghttps://conductscience.org/library/genes/2065NCBI Gene

1 to 10 of 34

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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