Paper · 24911653

An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation.

Zhang J and 4 others. Biochem J, 2014. Cited by 93 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation. Papers, record 24911653. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/24911653

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation.; PubMed
Journal: Biochem J; PubMed
Year: 2014; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/24911653/; PubMed
DOI: https://doi.org/10.1042/bj20140444; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC4206954/; PubMed
The journal: https://conductscience.org/library/journal-index/2984726R; PubMed
Citations, by iCite: 93; iCite
Relative citation ratio, by iCite: 2.31; iCite
Revised in PubMed: 2026-01-28; PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Zhang J	Jiazhen
2	Clark K	Kristopher
3	Lawrence T	Toby
4	Peggie MW	Mark W
5	Cohen P	Philip

Source PubMed

Topics22

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
I-kappa B Kinase	Major topic
MAP Kinase Kinase Kinases	Major topic
Protein Processing, Post-Translational	Major topic
Amino Acid Substitution
Animals
Cells, Cultured
Embryo, Mammalian
Enzyme Activation
Gene Knock-In Techniques
HEK293 Cells
Humans
Intracellular Signaling Peptides and Proteins
Mice
Mice, Transgenic
Mutant Proteins
Phosphorylation
Protein Interaction Domains and Motifs
Protein Kinase Inhibitors
Recombinant Proteins
Serine
Ubiquitination
MAP Kinase Kinase Kinase 7

Source PubMed

Grants8

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	Stated by
MC_U127084348	Medical Research Council	United Kingdom	PubMed
MC_EX_UU_G0800765	Medical Research Council	United Kingdom	PubMed
MRC-MR/K000985/1	Medical Research Council	United Kingdom	PubMed
MR/K000985/1	Medical Research Council	United Kingdom	PubMed
MC_EX_G0800765	Medical Research Council	United Kingdom	PubMed
100294	Wellcome Trust	United Kingdom	PubMed
20632	Versus Arthritis	United Kingdom	PubMed
MC_UU_12016/11	Medical Research Council	United Kingdom	PubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

Kind	PMID	Title	In Papers
Comment in	25,195,736	Priming IKKβ kinase for action.	https://conductscience.org/library/papers/25195736

Source PubMed

References31

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	19,185,524	Structural basis for recognition of diubiquitins by NEMO.	Mol Cell	2009	https://conductscience.org/library/papers/19185524	PubMed
2	15,590,691	Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2.	J Biol Chem	2005	https://conductscience.org/library/papers/15590691	PubMed
3	9,657,155	Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation.	Cell	1998	https://conductscience.org/library/papers/9657155	PubMed
4	12,372,426	TAK1-TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways.	Biochem Biophys Res Commun	2002	https://conductscience.org/library/papers/12372426	PubMed
5	17,006,537	A ubiquitin ligase complex assembles linear polyubiquitin chains.	EMBO J	2006	https://conductscience.org/library/papers/17006537	PubMed
6	19,136,968	Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.	Nat Cell Biol	2009	https://conductscience.org/library/papers/19136968	PubMed
7	21,138,416	Novel cross-talk within the IKK family controls innate immunity.	Biochem J	2011	https://conductscience.org/library/papers/21138416	PubMed
8	17,047,224	Regulation and function of IKK and IKK-related kinases.	Sci STKE	2006	https://conductscience.org/library/papers/17047224	PubMed
9	15,858,576	IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation.	Nature	2005	https://conductscience.org/library/papers/15858576	PubMed
10	16,260,493	TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.	Genes Dev	2005	https://conductscience.org/library/papers/16260493	PubMed

1 to 10 of 31

See all 31 references

Cited by70

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 93 citations.

PMID	Title	Journal	Year	In Papers	Source
42,897,482	Coordinated upregulation of Hippo, NF-κB and interferon pathway genes in pancreatic ductal adenocarcinoma: a retrospective tissue qRT-PCR profiling study with external tumour-versus-non-tumour validation, molecular subtype and survival analyses.	BMC Gastroenterol	2026	https://conductscience.org/library/papers/42897482	PubMed
42,589,430	Research Progress on Astaxanthin Plus Exercise for the Prevention and Treatment of Knee Osteoarthritis: A Traditional Narrative Review.	Int J Mol Sci	2026	https://conductscience.org/library/papers/42589430	PubMed
42,015,143	The roles of IKKα in normal physiology and cancer.	Cell Commun Signal	2026	https://conductscience.org/library/papers/42015143	PubMed
41,922,847	NEMO/IKKγ: Emerging player in the NF-κB pathway and potential therapeutic target in inflammation.	Inflammation	2026	https://conductscience.org/library/papers/41922847	PubMed
41,882,227	GTPase Rab11b and effector Rab11-FIP2 promote NLRP3 stability during inflammasome priming.	EMBO J	2026	https://conductscience.org/library/papers/41882227	PubMed
40,763,800	Double trouble: cytosolic and nuclear IKKα in cancer.	Open Biol	2025	https://conductscience.org/library/papers/40763800	PubMed
40,586,777	Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα through a phosphoenzyme intermediate.	Elife	2025	https://conductscience.org/library/papers/40586777	PubMed
39,996,775	NEMO Family of Proteins as Polyubiquitin Receptors: Illustrating Non-Degradative Polyubiquitination's Roles in Health and Disease.	Cells	2025	https://conductscience.org/library/papers/39996775	PubMed
39,409,019	Systems Biology Methods via Genome-Wide RNA Sequences to Investigate Pathogenic Mechanisms for Identifying Biomarkers and Constructing a DNN-Based Drug-Target Interaction Model to Predict Potential Molecular Drugs for Treating Atopic Dermatitis.	Int J Mol Sci	2024	https://conductscience.org/library/papers/39409019	PubMed
39,281,196	Met1-linked ubiquitination in cell signaling regulation.	Biophys Rep	2024	https://conductscience.org/library/papers/39281196	PubMed

1 to 10 of 70

See all 70 cited by

Genes11

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
CHUK	1,147	PubTator's text mining	https://conductscience.org/library/genes/1147	NCBI Gene
GAPDH	2,597	PubTator's text mining	https://conductscience.org/library/genes/2597	NCBI Gene
IKBKB	3,551	PubTator's text mining	https://conductscience.org/library/genes/3551	NCBI Gene
IKBKG	8,517	PubTator's text mining	https://conductscience.org/library/genes/8517	NCBI Gene
IL1A	3,552	PubTator's text mining	https://conductscience.org/library/genes/3552	NCBI Gene
MAP3K7	6,885	PubTator's text mining	https://conductscience.org/library/genes/6885	NCBI Gene
MAPK8	5,599	PubTator's text mining	https://conductscience.org/library/genes/5599	NCBI Gene
NFKB1	4,790	PubTator's text mining	https://conductscience.org/library/genes/4790	NCBI Gene
RNF31	55,072	PubTator's text mining	https://conductscience.org/library/genes/55072	NCBI Gene
TGFB1	7,040	PubTator's text mining	https://conductscience.org/library/genes/7040	NCBI Gene

1 to 10 of 11

See all 11 genes

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/24911653

GET https://conductscience.org/api/papers/v1/24911653/references?page=2

API reference For AI assistants