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Paper · 30082912

FGF18, a prominent player in FGF signaling, promotes gastric tumorigenesis through autocrine manner and is negatively regulated by miR-590-5p.

Zhang J and 17 others. Oncogene, 2019. Cited by 47 papers, by iCite.

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ConductScience Library. FGF18, a prominent player in FGF signaling, promotes gastric tumorigenesis through autocrine manner and is negatively regulated by miR-590-5p. Papers, record 30082912. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/30082912

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
FGF18, a prominent player in FGF signaling, promotes gastric tumorigenesis through autocrine manner and is negatively regulated by miR-590-5p.
PubMed
Journal
Oncogene
PubMed
Year
2019
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
47
iCite
Relative citation ratio, by iCite
1.97
iCite
Revised in PubMed
2020-03-09
PubMed

Authors18

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Zhang JJinglin
2Zhou YYuhang
3Huang TTingting
4Wu FFeng
5Pan YYihttps://orcid.org/0000-0001-9734-6398
6Dong YYujuan
7Wang YYan
8Chan AKYAden K Yhttps://orcid.org/0000-0001-9176-963X
9Liu LLiping
10Kwan JSHJohnny S H

1 to 10 of 18Source PubMed

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Topics21

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Fibroblast Growth FactorsMajor topic
MicroRNAsMajor topic
Neoplasm ProteinsMajor topic
RNA, NeoplasmMajor topic
Stomach NeoplasmsMajor topic
Animals
Autocrine Communication
Cell Line, Tumor
Cell Transformation, Neoplastic
Chromosomal Instability
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Gene Knockdown Techniques
Heterografts
Humans
Mice
Prognosis
RNA Interference
Recombinant Proteins
Signal Transduction
Up-Regulation

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
Direct Grant 2017.001Chinese University of Hong Kong (CUHK)InternationalPubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References46

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
115,781,473Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis.J Biol Chem2005https://conductscience.org/library/papers/15781473PubMed
229,367,737miR-375 is involved in Hippo pathway by targeting YAP1/TEAD4-CTGF axis in gastric carcinogenesis.Cell Death Dis2018https://conductscience.org/library/papers/29367737PubMed
316,465,403FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells.Int J Mol Med2006https://conductscience.org/library/papers/16465403PubMed
412,808,457PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.Nat Genet2003https://conductscience.org/library/papers/12808457PubMed
518,426,918miRDB: a microRNA target prediction and functional annotation database with a wiki interface.RNA2008https://conductscience.org/library/papers/18426918PubMed
624,288,179MicroRNA-590 promotes cervical cancer cell growth and invasion by targeting CHL1.J Cell Biochem2014https://conductscience.org/library/papers/24288179PubMed
723,732,477Molecular mechanisms of fibroblast growth factor signaling in physiology and pathology.Cold Spring Harb Perspect Biol2013https://conductscience.org/library/papers/23732477PubMed
827,230,412FGFR2 in gastric cancer: protein overexpression predicts gene amplification and high H-index predicts poor survival.Mod Pathol2016https://conductscience.org/library/papers/27230412PubMed
923,493,349FGFR2 gene amplification in gastric cancer predicts sensitivity to the selective FGFR inhibitor AZD4547.Clin Cancer Res2013https://conductscience.org/library/papers/23493349PubMed
1028,433,598MiR-590-5p, a density-sensitive microRNA, inhibits tumorigenesis by targeting YAP1 in colorectal cancer.Cancer Lett2017https://conductscience.org/library/papers/28433598PubMed

1 to 10 of 46

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Cited by44

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 47 citations.

PMIDTitleJournalYearIn PapersSource
42,891,186Genetically determined heterogeneous treatment effects of Helicobacter pylori eradication for targeted gastric cancer prevention.Innovation (Camb)2026https://conductscience.org/library/papers/42891186PubMed
42,360,909FGF18 mediates fibroblast-leukemia cross talk to promote acute myeloid leukemia progression.Blood2026https://conductscience.org/library/papers/42360909PubMed
42,258,013The interaction between inflammation and estrogen in adenomyosis : from molecular mechanisms to therapeutic strategies.Semin Immunopathol2026https://conductscience.org/library/papers/42258013PubMed
41,032,745Wilms Tumor 1-Expressing Stromal Cells Promote Pancreatic Cancer Progression.Cancer Res2026https://conductscience.org/library/papers/41032745PubMed
40,957,879Transgenerational inheritance of diminished ovarian reserve triggered by prenatal propylparaben exposure in mice.Nat Commun2025https://conductscience.org/library/papers/40957879PubMed
40,471,218Implications of miRNA-590 dysregulation in digestive tract malignancies: mechanistic aspects and clinical significance.Mol Biol Rep2025https://conductscience.org/library/papers/40471218PubMed
39,852,234High FGF18 expression levels predict poor prognosis in endometrial carcinoma patients and promote tumor growth and metastasis.J Int Med Res2025https://conductscience.org/library/papers/39852234PubMed
39,466,827Exploring the diagnostic potential of miRNA signatures in the Fabry disease serum: A comparative study of automated and manual sample isolations.PLoS One2024https://conductscience.org/library/papers/39466827PubMed
38,591,079Roles of fibroblast growth factors in the treatment of diabetes.World J Diabetes2024https://conductscience.org/library/papers/38591079PubMed
38,017,477miR-590-5p/Tiam1-mediated glucose metabolism promotes malignant evolution of pancreatic cancer by regulating SLC2A3 stability.Cancer Cell Int2023https://conductscience.org/library/papers/38017477PubMed

1 to 10 of 44

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Genes40

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ARRB2409PubTator's text mininghttps://conductscience.org/library/genes/409NCBI Gene
ATM472PubTator's text mininghttps://conductscience.org/library/genes/472NCBI Gene
ATR545PubTator's text mininghttps://conductscience.org/library/genes/545NCBI Gene
CCND1595PubTator's text mininghttps://conductscience.org/library/genes/595NCBI Gene
CDH1999PubTator's text mininghttps://conductscience.org/library/genes/999NCBI Gene
CDH21,000PubTator's text mininghttps://conductscience.org/library/genes/1000NCBI Gene
CDK41,019PubTator's text mininghttps://conductscience.org/library/genes/1019NCBI Gene
CDK61,021PubTator's text mininghttps://conductscience.org/library/genes/1021NCBI Gene
CTBP11,487PubTator's text mininghttps://conductscience.org/library/genes/1487NCBI Gene
CTNNB11,499PubTator's text mininghttps://conductscience.org/library/genes/1499NCBI Gene

1 to 10 of 40

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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