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Paper · 32057769

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade.

Coutard B and 5 others. Antiviral Res, 2020. Cited by 1,188 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade. Papers, record 32057769. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/32057769

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade.
PubMed
Journal
Antiviral Res
PubMed
Year
2020
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
1,188
iCite
Relative citation ratio, by iCite
61.4
iCite
Revised in PubMed
2020-12-24
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Coutard BB
2Valle CC
3de Lamballerie XX
4Canard BB
5Seidah NGN G
6Decroly EE

Source PubMed

Topics7

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
BetacoronavirusMajor topic
FurinMajor topic
Spike Glycoprotein, CoronavirusMajor topic
Amino Acid Sequence
Genome, Viral
Protein Conformation
SARS-CoV-2

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References35

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
131,406,574Furin-mediated protein processing in infectious diseases and cancer.Clin Transl Immunology2019https://conductscience.org/library/papers/31406574PubMed
29,166,946Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours.Br J Cancer1997https://conductscience.org/library/papers/9166946PubMed
331,995,857Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia.N Engl J Med2020https://conductscience.org/library/papers/31995857PubMed
431,987,001Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan.Emerg Microbes Infect2020https://conductscience.org/library/papers/31987001PubMed
522,679,642The biology and therapeutic targeting of the proprotein convertases.Nat Rev Drug Discov2012https://conductscience.org/library/papers/22679642PubMed
631,996,437Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus.J Virol2020https://conductscience.org/library/papers/31996437PubMed
726,545,254Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System.PLoS Pathog2015https://conductscience.org/library/papers/26545254PubMed
820,926,566Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2.J Virol2010https://conductscience.org/library/papers/20926566PubMed
927,584,082Targeting proprotein convertases in furin-rich lung cancer cells results in decreased in vitro and in vivo growth.Mol Carcinog2017https://conductscience.org/library/papers/27584082PubMed
1016,116,101Protease-mediated enhancement of severe acute respiratory syndrome coronavirus infection.Proc Natl Acad Sci U S A2005https://conductscience.org/library/papers/16116101PubMed

1 to 10 of 35

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Cited by968

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1,188 citations.

PMIDTitleJournalYearIn PapersSource
42,716,929Loss-of-function mutation in Omicron variants reduces spike protein expression and attenuates SARS-CoV-2 infection.Nat Commun2026https://conductscience.org/library/papers/42716929PubMed
42,405,771Disruption of the S1/S2 multibasic cleavage site attenuates infectious bronchitis virus, while S2' partially restores viral virulence and expands tissue tropism.J Virol2026https://conductscience.org/library/papers/42405771PubMed
42,395,031Molecular, cellular and network mapping of brain structural deviations in patients with Post-COVID19 syndrome.Brain Behav Immun Health2026https://conductscience.org/library/papers/42395031PubMed
42,307,396Alert on a Novel South American Bat Coronavirus with a Furin-Cleavage Site: A One Health Early Warning.Rev Soc Bras Med Trop2026https://conductscience.org/library/papers/42307396PubMed
41,885,456Secretory full-length human prosaposin (PSAP) inhibits SARS-CoV-2 infection through facilitating the release of S1 subunit of spike protein.mBio2026https://conductscience.org/library/papers/41885456PubMed
41,761,653Structural Basis of MERS-CoV Receptor Interactions and Antibody Neutralisations.Rev Med Virol2026https://conductscience.org/library/papers/41761653PubMed
41,752,447A Double-Edged Sword: Extracellular Serine Proteases as Facilitators of Infection and Mediators of Immunity.Molecules2026https://conductscience.org/library/papers/41752447PubMed
41,513,808K5 polysaccharides inhibit SARS-CoV-2 infection by preventing spike-proteolytic priming.Npj Viruses2026https://conductscience.org/library/papers/41513808PubMed
41,488,148Molecular analysis of long COVID and new-onset diabetes mellitus: pathobiological relationships and current mechanistic views.Front Endocrinol (Lausanne)2025https://conductscience.org/library/papers/41488148PubMed
41,480,662Epidemiological indicators of accidental laboratory-origin outbreaks.Epidemiol Infect2026https://conductscience.org/library/papers/41480662PubMed

1 to 10 of 968

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Genes12

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ACE259,272PubTator's text mininghttps://conductscience.org/library/genes/59272NCBI Gene
CD17757,126PubTator's text mininghttps://conductscience.org/library/genes/57126NCBI Gene
CTSL1,514PubTator's text mininghttps://conductscience.org/library/genes/1514NCBI Gene
ERVK-664,006PubTator's text mininghttps://conductscience.org/library/genes/64006NCBI Gene
F2R2,149PubTator's text mininghttps://conductscience.org/library/genes/2149NCBI Gene
FURIN5,045PubTator's text mininghttps://conductscience.org/library/genes/5045NCBI Gene
PCSK55,125PubTator's text mininghttps://conductscience.org/library/genes/5125NCBI Gene
PCSK65,046PubTator's text mininghttps://conductscience.org/library/genes/5046NCBI Gene
PCSK79,159PubTator's text mininghttps://conductscience.org/library/genes/9159NCBI Gene
SERPINA15,265PubTator's text mininghttps://conductscience.org/library/genes/5265NCBI Gene

1 to 10 of 12

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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