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Paper · 33223752

Tim-3 promotes cell aggressiveness and paclitaxel resistance through NF-κB/STAT3 signalling pathway in breast cancer cells.

Cong Y and 8 others. Chin J Cancer Res, 2020. Cited by 42 papers, by iCite.

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ConductScience Library. Tim-3 promotes cell aggressiveness and paclitaxel resistance through NF-κB/STAT3 signalling pathway in breast cancer cells. Papers, record 33223752. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/33223752

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Tim-3 promotes cell aggressiveness and paclitaxel resistance through NF-κB/STAT3 signalling pathway in breast cancer cells.
PubMed
Journal
Chin J Cancer Res
PubMed
Year
2020
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
42
iCite
Relative citation ratio, by iCite
1.91
iCite
Revised in PubMed
2022-04-18
PubMed

Authors9

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Cong YYizi
2Cui YYuxin
3Zhu SShiguang
4Cao JJianqiao
5Zou HHaidong
6Martin TATracey A
7Qiao GGuangdong
8Jiang WWenguo
9Yu ZZhigang

Source PubMed

Topics0

NLM's MeSH indexing of the paper, its major topics first.

None in this release.

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References52

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
132,410,791Cancer burden and trends in China: A review and comparison with Japan and South Korea.Chin J Cancer Res2020https://conductscience.org/library/papers/32410791PubMed
231,611,702Inhibitory receptors and ligands beyond PD-1, PD-L1 and CTLA-4: breakthroughs or backups.Nat Immunol2019https://conductscience.org/library/papers/31611702PubMed
324,339,967Decreased galectin-9 and increased Tim-3 expression are related to poor prognosis in gastric cancer.PLoS One2013https://conductscience.org/library/papers/24339967PubMed
422,207,048VEGF-A/VEGFR-2 signaling plays an important role for the motility of pancreas cancer cells.Ann Surg Oncol2012https://conductscience.org/library/papers/22207048PubMed
524,195,506Prognostic implication of TIM-3 in clear cell renal cell carcinoma.Neoplasma2014https://conductscience.org/library/papers/24195506PubMed
623,240,746Taming dendritic cells with TIM-3: another immunosuppressive strategy used by tumors.Immunotherapy2012https://conductscience.org/library/papers/23240746PubMed
724,137,353TIM-3 expression in human osteosarcoma: Correlation with the expression of epithelial-mesenchymal transition-specific biomarkers.Oncol Lett2013https://conductscience.org/library/papers/24137353PubMed
826,559,373Constitutive activation of STAT3 in breast cancer cells: A review.Int J Cancer2016https://conductscience.org/library/papers/26559373PubMed
930,867,218Combined Inhibition of STAT3 and DNA Repair in Palbociclib-Resistant ER-Positive Breast Cancer.Clin Cancer Res2019https://conductscience.org/library/papers/30867218PubMed
1027,580,405Endothelial STAT3 Activation Increases Vascular Leakage Through Downregulating Tight Junction Proteins: Implications for Diabetic Retinopathy.J Cell Physiol2017https://conductscience.org/library/papers/27580405PubMed

1 to 10 of 52

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Cited by27

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 42 citations.

PMIDTitleJournalYearIn PapersSource
42,653,191Mechanisms of Paclitaxel Resistance: Recent Advances and Future Perspectives.Int J Mol Sci2026https://conductscience.org/library/papers/42653191PubMed
42,274,584The Signaling Networks of TIM-3, TGF-β, and STING in Glioblastoma.Cells2026https://conductscience.org/library/papers/42274584PubMed
41,437,770Immune checkpoint TIM-3 in tumor immunotherapy.Acta Biochim Biophys Sin (Shanghai)2026https://conductscience.org/library/papers/41437770PubMed
41,301,931TIM-3 Promotes Proliferation of Acute Myeloid Leukemia Blasts.Biomedicines2025https://conductscience.org/library/papers/41301931PubMed
40,999,423The concurrent silencing of Tim-3 and STAT-3 promotes tumor regression both in vitro and in ovo.BMC Cancer2025https://conductscience.org/library/papers/40999423PubMed
40,877,243A strategy for challenging tumorous bone regeneration by borosilicate bioactive glass boosting moderate magnetic hyperthermia.Nat Commun2025https://conductscience.org/library/papers/40877243PubMed
40,704,280Molecular mechanisms underlying the inhibition of cell migration and invasion in endometriosis: Advances in pharmacological research (Review).Biomed Rep2025https://conductscience.org/library/papers/40704280PubMed
40,645,187TIM3+ breast cancer cells license immune evasion during micrometastasis outbreak.Cancer Cell2025https://conductscience.org/library/papers/40645187PubMed
40,281,554Reprogramming the breast tumor immune microenvironment: cold-to-hot transition for enhanced immunotherapy.J Exp Clin Cancer Res2025https://conductscience.org/library/papers/40281554PubMed
39,717,767CD8+ T cell exhaustion in the tumor microenvironment of breast cancer.Front Immunol2024https://conductscience.org/library/papers/39717767PubMed

1 to 10 of 27

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Genes32

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
BCL2596PubTator's text mininghttps://conductscience.org/library/genes/596NCBI Gene
BCL2L1598PubTator's text mininghttps://conductscience.org/library/genes/598NCBI Gene
CCND1595PubTator's text mininghttps://conductscience.org/library/genes/595NCBI Gene
CDH1999PubTator's text mininghttps://conductscience.org/library/genes/999NCBI Gene
CLDN19,076PubTator's text mininghttps://conductscience.org/library/genes/9076NCBI Gene
CTNNB11,499PubTator's text mininghttps://conductscience.org/library/genes/1499NCBI Gene
EGF1,950PubTator's text mininghttps://conductscience.org/library/genes/1950NCBI Gene
ERBB22,064PubTator's text mininghttps://conductscience.org/library/genes/2064NCBI Gene
FSCN16,624PubTator's text mininghttps://conductscience.org/library/genes/6624NCBI Gene
GAPDH2,597PubTator's text mininghttps://conductscience.org/library/genes/2597NCBI Gene

1 to 10 of 32

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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