Paper · 33256240

The Role of BRAF in Metastatic Colorectal Carcinoma-Past, Present, and Future.

Djanani A and 4 others. Int J Mol Sci, 2020. Cited by 17 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The Role of BRAF in Metastatic Colorectal Carcinoma-Past, Present, and Future. Papers, record 33256240. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/33256240

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: The Role of BRAF in Metastatic Colorectal Carcinoma-Past, Present, and Future.; PubMed
Journal: Int J Mol Sci; PubMed
Year: 2020; PubMed
Publication types: Journal Article, Review; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/33256240/; PubMed
DOI: https://doi.org/10.3390/ijms21239001; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC7729567/; PubMed
The journal: https://conductscience.org/library/journal-index/101092791; PubMed
Citations, by iCite: 17; iCite
Relative citation ratio, by iCite: 0.57; iCite
Revised in PubMed: 2023-11-04; PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	ORCID iD
1	Djanani A	Angela
2	Eller S	Silvia
3	Öfner D	Dietmar	https://orcid.org/0000-0001-8909-8566
4	Troppmair J	Jakob	https://orcid.org/0000-0002-0611-3837
5	Maglione M	Manuel	https://orcid.org/0000-0003-1479-6129

Source PubMed

Topics8

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Colorectal Neoplasms	Major topic
Proto-Oncogene Proteins B-raf	Major topic
Animals
Drug Resistance, Neoplasm
Humans
Molecular Targeted Therapy
Neoplasm Metastasis
Signal Transduction

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References115

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	27,198,569	PD-L1 expression in colorectal cancer is associated with microsatellite instability, BRAF mutation, medullary morphology and cytotoxic tumor-infiltrating lymphocytes.	Mod Pathol	2016	https://conductscience.org/library/papers/27198569	PubMed
2	18,316,791	Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer.	J Clin Oncol	2008	https://conductscience.org/library/papers/18316791	PubMed
3	32,919,890	Long-term Clinical Outcome of Trastuzumab and Lapatinib for HER2-positive Metastatic Colorectal Cancer.	Clin Colorectal Cancer	2020	https://conductscience.org/library/papers/32919890	PubMed
4	26,742,998	Cancer statistics, 2016.	CA Cancer J Clin	2016	https://conductscience.org/library/papers/26742998	PubMed
5	25,139,339	Mismatch repair status and BRAF mutation status in metastatic colorectal cancer patients: a pooled analysis of the CAIRO, CAIRO2, COIN, and FOCUS studies.	Clin Cancer Res	2014	https://conductscience.org/library/papers/25139339	PubMed
6	21,646,616	Impact of KRAS and BRAF Gene Mutation Status on Outcomes From the Phase III AGITG MAX Trial of Capecitabine Alone or in Combination With Bevacizumab and Mitomycin in Advanced Colorectal Cancer.	J Clin Oncol	2011	https://conductscience.org/library/papers/21646616	PubMed
7	8,861,899	Lessons from hereditary colorectal cancer.	Cell	1996	https://conductscience.org/library/papers/8861899	PubMed
8	19,603,024	Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer.	Br J Cancer	2009	https://conductscience.org/library/papers/19603024	PubMed
9	32,249,628	The discovery and development of binimetinib for the treatment of melanoma.	Expert Opin Drug Discov	2020	https://conductscience.org/library/papers/32249628	PubMed
10	16,649,144	Back to the roots: the remarkable RAF oncogene story.	Cell Mol Life Sci	2006	https://conductscience.org/library/papers/16649144	PubMed

1 to 10 of 115

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Cited by13

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 17 citations.

PMID	Title	Journal	Year	In Papers	Source
42,588,662	Factors Associated with the Timing of Liver Metastasis After Colorectal Cancer Surgery: A Retrospective Multicenter Study.	Cancers (Basel)	2026	https://conductscience.org/library/papers/42588662	PubMed
42,185,244	Cost-effectiveness analysis of encorafenib in untreated BRAF V600E-mutant metastatic colorectal cancer in China.	Pharmacogenomics J	2026	https://conductscience.org/library/papers/42185244	PubMed
41,439,081	Molecular Profiling of KRAS, NRAS, and BRAF in Colorectal Cancer: Insights From a Libyan Cohort.	Cureus	2025	https://conductscience.org/library/papers/41439081	PubMed
40,619,745	Adagrasib in the treatment of colorectal cancer.	Future Oncol	2025	https://conductscience.org/library/papers/40619745	PubMed
40,234,937	LINC02167 stabilizes KSR1 mRNA in an m5C-dependent manner to regulate the ERK/MAPK signaling pathway and promotes colorectal cancer metastasis.	J Exp Clin Cancer Res	2025	https://conductscience.org/library/papers/40234937	PubMed
40,083,375	Precision medicine in colorectal cancer: genomics profiling and targeted treatment.	Front Pharmacol	2025	https://conductscience.org/library/papers/40083375	PubMed
39,591,358	Expression of Mutated BRAFV595E Kinase in Canine Carcinomas-An Immunohistochemical Study.	Vet Sci	2024	https://conductscience.org/library/papers/39591358	PubMed
38,940,668	Progress in clinical diagnosis and treatment of colorectal cancer with rare genetic variants.	Cancer Biol Med	2024	https://conductscience.org/library/papers/38940668	PubMed
38,136,364	In Vitro Organoid-Based Assays Reveal SMAD4 Tumor-Suppressive Mechanisms for Serrated Colorectal Cancer Invasion.	Cancers (Basel)	2023	https://conductscience.org/library/papers/38136364	PubMed
36,811,382	A Phase Ib/II Study of WNT974 + Encorafenib + Cetuximab in Patients With BRAF V600E-Mutant KRAS Wild-Type Metastatic Colorectal Cancer.	Oncologist	2023	https://conductscience.org/library/papers/36811382	PubMed

1 to 10 of 13

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Genes26

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
AKT1	207	PubTator's text mining	https://conductscience.org/library/genes/207	NCBI Gene
APC	324	PubTator's text mining	https://conductscience.org/library/genes/324	NCBI Gene
ARAF	369	PubTator's text mining	https://conductscience.org/library/genes/369	NCBI Gene
BRAF	673	PubTator's text mining	https://conductscience.org/library/genes/673	NCBI Gene
CD274	29,126	PubTator's text mining	https://conductscience.org/library/genes/29126	NCBI Gene
CTLA4	1,493	PubTator's text mining	https://conductscience.org/library/genes/1493	NCBI Gene
CTNNB1	1,499	PubTator's text mining	https://conductscience.org/library/genes/1499	NCBI Gene
EGF	1,950	PubTator's text mining	https://conductscience.org/library/genes/1950	NCBI Gene
EGFR	1,956	PubTator's text mining	https://conductscience.org/library/genes/1956	NCBI Gene
ERBB2	2,064	PubTator's text mining	https://conductscience.org/library/genes/2064	NCBI Gene

1 to 10 of 26

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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