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Paper · 35705804

Signatures of copy number alterations in human cancer.

Steele CD and 23 others. Nature, 2022. Cited by 407 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Signatures of copy number alterations in human cancer. Papers, record 35705804. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/35705804

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Signatures of copy number alterations in human cancer.
PubMed
Journal
Nature
PubMed
Year
2022
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
407
iCite
Relative citation ratio, by iCite
24.2
iCite
Revised in PubMed
2026-11-02
PubMed

Authors24

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Steele CDChristopher D
2Abbasi AAmmal
3Islam SMAS M Ashiqul
4Bowes ALAmy L
5Khandekar AAzhar
6Haase KKerstinhttps://orcid.org/0000-0002-0944-5618
7Hames-Fathi SShadi
8Ajayi DDolapo
9Verfaillie AAnnelien
10Dhami PPawan

1 to 10 of 24Source PubMed

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Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
DNA Copy Number VariationsMajor topic
DNA Mutational AnalysisMajor topic
NeoplasmsMajor topic
Aneuploidy
Chromothripsis
Haploidy
Homologous Recombination
Humans
Loss of Heterozygosity
Mutation
Exome Sequencing

Source PubMed

Grants4

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
18387Cancer Research UKUnited KingdomPubMedPubMed
MR/L016311/1Medical Research CouncilUnited KingdomPubMedPubMed
R01 ES030993NIEHS NIH HHSUnited StatesR01ES030993PubMed and NIHNIH RePORTER
R01 ES032547NIEHS NIH HHSUnited StatesR01ES032547PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Comment in35,764,797Copy-number classifiers for cancer.https://conductscience.org/library/papers/35764797

Source PubMed

References73

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
128,199,314Whole-genome landscape of pancreatic neuroendocrine tumours.Nature2017https://conductscience.org/library/papers/28199314PubMed
222,544,022Absolute quantification of somatic DNA alterations in human cancer.Nat Biotechnol2012https://conductscience.org/library/papers/22544022PubMed
323,442,169Copynumber: Efficient algorithms for single- and multi-track copy number segmentation.BMC Genomics2012https://conductscience.org/library/papers/23442169PubMed
430,889,380Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways.Cancer Cell2019https://conductscience.org/library/papers/30889380PubMed
531,036,964Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids.Nat Genet2019https://conductscience.org/library/papers/31036964PubMed
626,415,501A cell-based model system links chromothripsis with hyperploidy.Mol Syst Biol2015https://conductscience.org/library/papers/26415501PubMed
729,925,010The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma.Cell Rep2018https://conductscience.org/library/papers/29925010PubMed
836,388,765Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor.Cell Genom2022https://conductscience.org/library/papers/36388765PubMed
923,718,828Targeted next-generation sequencing of head and neck squamous cell carcinoma identifies novel genetic alterations in HPV+ and HPV- tumors.Genome Med2013https://conductscience.org/library/papers/23718828PubMed
1032,807,987Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers.Nat Genet2020https://conductscience.org/library/papers/32807987PubMed

1 to 10 of 73

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Cited by325

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 407 citations.

PMIDTitleJournalYearIn PapersSource
42,975,825LC-WGS-based Chromosomal Instability Analysis of EUS-FNA Specimens for Diagnosing Solid Pancreatic Lesions.Ann Surg Oncol2026https://conductscience.org/library/papers/42975825PubMed
42,951,966Perinatal elimination of genetically aberrant human cortical neurons.Nature2026https://conductscience.org/library/papers/42951966PubMed
42,883,885Genome-Wide Characterisation of Somatic Mutations Across COSMIC Cancer Cell Lines Enables Gene-Centric Experimental Model Selection.Int J Mol Sci2026https://conductscience.org/library/papers/42883885PubMed
42,875,489Divergent genomic evolution in astrocytomas and oligodendrogliomas.Nature2026https://conductscience.org/library/papers/42875489PubMed
42,838,986Benchmarking copy number alteration inference methods for spatial transcriptomics.Nat Commun2026https://conductscience.org/library/papers/42838986PubMed
42,818,230FFPE-CUTAC: A Single Assay, Multiple Layers.bioRxiv2026https://conductscience.org/library/papers/42818230PubMed
42,791,387Unraveling the lexicon of complex mutational phenomena in human cancers.Nat Cancer2026https://conductscience.org/library/papers/42791387PubMed
42,737,428Whole-Exome Sequencing Identifies Candidate Genomic Features Associated with Response to Platinum-Based Chemotherapy and Ixabepilone-Based Treatment in Ovarian Cancer.Int J Mol Sci2026https://conductscience.org/library/papers/42737428PubMed
42,717,445Identifying multigenic modules under selection in the tumor genome.Bioinformatics2026https://conductscience.org/library/papers/42717445PubMed
42,717,056A guide to understanding tumour evolution through the lens of population genetics.Nat Rev Cancer2026https://conductscience.org/library/papers/42717056PubMed

1 to 10 of 325

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Genes25

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
APRT353PubTator's text mininghttps://conductscience.org/library/genes/353NCBI Gene
BRAF673PubTator's text mininghttps://conductscience.org/library/genes/673NCBI Gene
BRCA1672PubTator's text mininghttps://conductscience.org/library/genes/672NCBI Gene
BRCA2675PubTator's text mininghttps://conductscience.org/library/genes/675NCBI Gene
CCNE1898PubTator's text mininghttps://conductscience.org/library/genes/898NCBI Gene
CDK1251,755PubTator's text mininghttps://conductscience.org/library/genes/51755NCBI Gene
CDKN2A1,029PubTator's text mininghttps://conductscience.org/library/genes/1029NCBI Gene
CNDP255,748PubTator's text mininghttps://conductscience.org/library/genes/55748NCBI Gene
EGFR1,956PubTator's text mininghttps://conductscience.org/library/genes/1956NCBI Gene
ERBB22,064PubTator's text mininghttps://conductscience.org/library/genes/2064NCBI Gene

1 to 10 of 25

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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