ConductScience.org, home
Papers
API referenceFor AI assistants

Paper · 37001042

TREM2 acts as a receptor for IL-34 to suppress acute myeloid leukemia in mice.

Xie X and 20 others. Blood, 2023. Cited by 38 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Download JSON
Cite this record

ConductScience Library. TREM2 acts as a receptor for IL-34 to suppress acute myeloid leukemia in mice. Papers, record 37001042. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/37001042

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
TREM2 acts as a receptor for IL-34 to suppress acute myeloid leukemia in mice.
PubMed
Journal
Blood
PubMed
Year
2023
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
38
iCite
Relative citation ratio, by iCite
3.24
iCite
Revised in PubMed
2026-01-27
PubMed

Authors21

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Xie XXiaolinghttps://orcid.org/0000-0003-1970-4537
2Zhang WWujuhttps://orcid.org/0000-0001-8500-5377
3Xiao MMin
4Wei TTiantian
5Qiu YYingqi
6Qiu JJingyang
7Wang HHao
8Qiu ZZeyou
9Zhang SSheng
10Pan YYating

1 to 10 of 21Source PubMed

See all 21 authors

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Leukemia, Myeloid, AcuteMajor topic
Animals
Mice
Bone Marrow
Carrier Proteins
Interleukins
Signal Transduction
Tumor Microenvironment
Membrane Glycoproteins
Receptors, Immunologic

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Comment in37,383,007IL-34: a novel differentiation therapy for AML?https://conductscience.org/library/papers/37383007

Source PubMed

References56

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
125,662,098Syndecan-1 regulates the biological activities of interleukin-34.Biochim Biophys Acta2015https://conductscience.org/library/papers/25662098PubMed
228,602,351A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.Cell2017https://conductscience.org/library/papers/28602351PubMed
332,214,235Construction of a human cell landscape at single-cell level.Nature2020https://conductscience.org/library/papers/32214235PubMed
419,951,971Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia.Haematologica2010https://conductscience.org/library/papers/19951971PubMed
517,220,916Activating and inhibitory functions of DAP12.Nat Rev Immunol2007https://conductscience.org/library/papers/17220916PubMed
612,925,681DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features.J Exp Med2003https://conductscience.org/library/papers/12925681PubMed
720,504,948Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells.J Leukoc Biol2010https://conductscience.org/library/papers/20504948PubMed
826,376,137Acute Myeloid Leukemia.N Engl J Med2015https://conductscience.org/library/papers/26376137PubMed
930,066,957Interleukin-34, a comprehensive review.J Leukoc Biol2018https://conductscience.org/library/papers/30066957PubMed
1020,671,123IκB kinase overcomes PI3K/Akt and ERK/MAPK to control FOXO3a activity in acute myeloid leukemia.Blood2010https://conductscience.org/library/papers/20671123PubMed

1 to 10 of 56

See all 56 references

Cited by27

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 38 citations.

PMIDTitleJournalYearIn PapersSource
42,761,463IL-34 in neurological homeostasis and its multifaceted roles in central nervous system diseases.Front Immunol2026https://conductscience.org/library/papers/42761463PubMed
42,694,581Roles of IL-34 in neurological diseases: neuroprotection, inflammatory regulation, and myeloid plasticity.Front Immunol2026https://conductscience.org/library/papers/42694581PubMed
42,360,909FGF18 mediates fibroblast-leukemia cross talk to promote acute myeloid leukemia progression.Blood2026https://conductscience.org/library/papers/42360909PubMed
42,272,524Crosstalk between bone and vasculature within bone.Fundam Res2026https://conductscience.org/library/papers/42272524PubMed
41,951,894Cytokine multimerization: when more is more and sometimes less.Nat Rev Immunol2026https://conductscience.org/library/papers/41951894PubMed
41,868,658TREM2 inhibits cholangiocarcinoma progression by regulating the TGF-β/Smad2/3 signaling pathway.Am J Cancer Res2026https://conductscience.org/library/papers/41868658PubMed
41,460,571Macrophage Trem2 deficiency aggravates aging-induced vascular remodeling by acting as a non-classical receptor of interleukin-13.Mol Biomed2025https://conductscience.org/library/papers/41460571PubMed
41,449,430Role of TREM2 in neuroinflammation regulation: mechanisms, disease associations, and therapeutic translation advances.J Transl Med2025https://conductscience.org/library/papers/41449430PubMed
41,168,805Roles of TREM2 in Alzheimer's disease.Transl Neurodegener2025https://conductscience.org/library/papers/41168805PubMed
41,034,525MAP4K signaling pathways in cancer: roles, mechanisms and therapeutic opportunities.Exp Mol Med2025https://conductscience.org/library/papers/41034525PubMed

1 to 10 of 27

See all 27 cited by

Genes20

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CD14929PubTator's text mininghttps://conductscience.org/library/genes/929NCBI Gene
CD33945PubTator's text mininghttps://conductscience.org/library/genes/945NCBI Gene
CD34947PubTator's text mininghttps://conductscience.org/library/genes/947NCBI Gene
CSF1R1,436PubTator's text mininghttps://conductscience.org/library/genes/1436NCBI Gene
GAPDH2,597PubTator's text mininghttps://conductscience.org/library/genes/2597NCBI Gene
HAL3,034PubTator's text mininghttps://conductscience.org/library/genes/3034NCBI Gene
IL34146,433PubTator's text mininghttps://conductscience.org/library/genes/146433NCBI Gene
ITGAM3,684PubTator's text mininghttps://conductscience.org/library/genes/3684NCBI Gene
KMT2A4,297PubTator's text mininghttps://conductscience.org/library/genes/4297NCBI Gene
MAPK15,594PubTator's text mininghttps://conductscience.org/library/genes/5594NCBI Gene

1 to 10 of 20

See all 20 genes

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/37001042

GET https://conductscience.org/api/papers/v1/37001042/authors?page=2

API referenceFor AI assistants