Paper · 42589604

Myofibroblastic CAF and Malignant Ductal Cell Crosstalk Drives Epithelial-Mesenchymal Transition and Progression in Pancreatic Ductal Adenocarcinoma via THBS2-SDC/Integrin Axes.

Ren Z and 7 others. Int J Mol Sci, 2026. Cited by 0 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Myofibroblastic CAF and Malignant Ductal Cell Crosstalk Drives Epithelial-Mesenchymal Transition and Progression in Pancreatic Ductal Adenocarcinoma via THBS2-SDC/Integrin Axes. Papers, record 42589604. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42589604

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Myofibroblastic CAF and Malignant Ductal Cell Crosstalk Drives Epithelial-Mesenchymal Transition and Progression in Pancreatic Ductal Adenocarcinoma via THBS2-SDC/Integrin Axes.; PubMed
Journal: Int J Mol Sci; PubMed
Year: 2026; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/42589604/; PubMed
DOI: https://doi.org/10.3390/ijms27156951; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC13466557/; PubMed
The journal: https://conductscience.org/library/journal-index/101092791; PubMed
Citations, by iCite: 0; iCite
Revised in PubMed: 2026-08-15; PubMed

Authors8

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	ORCID iD
1	Ren Z	Zhonglu	https://orcid.org/0000-0001-8834-0779
2	Li Z	Zhuangchang
3	Wang J	Jie
4	Liu Y	Yuchen
5	Chen L	Lidan
6	Su Y	Yuxin
7	Zhao L	Limin
8	Liu X	Xi

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Epithelial-Mesenchymal Transition	Major topic
Carcinoma, Pancreatic Ductal	Major topic
Pancreatic Neoplasms	Major topic
Integrins	Major topic
Cancer-Associated Fibroblasts	Major topic
Thrombospondins	Major topic
Myofibroblasts	Major topic
Humans
Thrombospondin 2
Gene Expression Regulation, Neoplastic
Signal Transduction
Cell Line, Tumor
Disease Progression

Source PubMed

Grants5

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Stated by
No. 20231219	Traditional Chinese Medicine Bureau of Guangdong Province	PubMed
No. B2025067	Health Commission of Guangdong Province	PubMed
No. 202201010764	Guangzhou Municipal Science and Technology Bureau	PubMed
2025 Provincial-level Project No. 45	Undergraduate Innovation and Training Program	PubMed
2026 National-level Project No. 202610573010	Undergraduate Innovation and Training Program	PubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References94

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	35,184,420	Revealing the transcriptional heterogeneity of organ-specific metastasis in human gastric cancer using single-cell RNA Sequencing.	Clin Transl Med	2022	https://conductscience.org/library/papers/35184420	PubMed
2	32,574,556	Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex.	Dev Cell	2020	https://conductscience.org/library/papers/32574556	PubMed
3	37,907,515	SDC1 and ITGA2 as novel prognostic biomarkers for PDAC related to IPMN.	Sci Rep	2023	https://conductscience.org/library/papers/37907515	PubMed
4	28,682,339	Upholding a role for EMT in pancreatic cancer metastasis.	Nature	2017	https://conductscience.org/library/papers/28682339	PubMed
5	34,804,159	The Integrative Analysis of Thrombospondin Family Genes in Pan-Cancer Reveals that THBS2 Facilitates Gastrointestinal Cancer Metastasis.	J Oncol	2021	https://conductscience.org/library/papers/34804159	PubMed
6	38,871,986	CellRank 2: unified fate mapping in multiview single-cell data.	Nat Methods	2024	https://conductscience.org/library/papers/38871986	PubMed
7	31,134,896	Transcriptional control of subtype switching ensures adaptation and growth of pancreatic cancer.	Elife	2019	https://conductscience.org/library/papers/31134896	PubMed
8	33,544,846	SPOTlight: seeded NMF regression to deconvolute spatial transcriptomics spots with single-cell transcriptomes.	Nucleic Acids Res	2021	https://conductscience.org/library/papers/33544846	PubMed
9	38,342,234	Single-cell transcriptomic analysis reveals the landscape of epithelial-mesenchymal transition molecular heterogeneity in esophageal squamous cell carcinoma.	Cancer Lett	2024	https://conductscience.org/library/papers/38342234	PubMed
10	40,973,793	Cancer-associated fibroblasts drive lung adenocarcinoma progression via THBS2-mediated epithelial-mesenchymal transition.	Oncogene	2025	https://conductscience.org/library/papers/40973793	PubMed

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Cited by0

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 0 citations.

None in this release.

Genes11

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
AKT1	207	PubTator's text mining	https://conductscience.org/library/genes/207	NCBI Gene
FN1	2,335	PubTator's text mining	https://conductscience.org/library/genes/2335	NCBI Gene
ITGA3	3,675	PubTator's text mining	https://conductscience.org/library/genes/3675	NCBI Gene
ITGB1	3,688	PubTator's text mining	https://conductscience.org/library/genes/3688	NCBI Gene
NFKB1	4,790	PubTator's text mining	https://conductscience.org/library/genes/4790	NCBI Gene
PIK3CB	5,291	PubTator's text mining	https://conductscience.org/library/genes/5291	NCBI Gene
SDC1	6,382	PubTator's text mining	https://conductscience.org/library/genes/6382	NCBI Gene
SDC4	6,385	PubTator's text mining	https://conductscience.org/library/genes/6385	NCBI Gene
TGFB1	7,040	PubTator's text mining	https://conductscience.org/library/genes/7040	NCBI Gene
THBS2	7,058	PubTator's text mining	https://conductscience.org/library/genes/7058	NCBI Gene

1 to 10 of 11

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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