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Paper · 7568175

Membrane-associated CD19-LYN complex is an endogenous p53-independent and Bc1-2-independent regulator of apoptosis in human B-lineage lymphoma cells.

Myers DE and 8 others. Proc Natl Acad Sci U S A, 1995. Cited by 38 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Membrane-associated CD19-LYN complex is an endogenous p53-independent and Bc1-2-independent regulator of apoptosis in human B-lineage lymphoma cells. Papers, record 7568175. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/7568175

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Membrane-associated CD19-LYN complex is an endogenous p53-independent and Bc1-2-independent regulator of apoptosis in human B-lineage lymphoma cells.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1995
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
38
iCite
Relative citation ratio, by iCite
0.7
iCite
Revised in PubMed
2019-05-01
PubMed

Authors9

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Myers DED E
2Jun XX
3Waddick KGK G
4Forsyth CC
5Chelstrom LML M
6Gunther RLR L
7Tumer NEN E
8Bolen JJ
9Uckun FMF M

Source PubMed

Topics20

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Antigens, CD19Major topic
ApoptosisMajor topic
Burkitt LymphomaMajor topic
src-Family KinasesMajor topic
Animals
Enzyme Inhibitors
Genistein
Humans
Immunoconjugates
Immunotoxins
Isoflavones
Mice
Mice, SCID
Neoplasms, Experimental
Protein Binding
Protein Conformation
Protein-Tyrosine Kinases
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
Tumor Suppressor Protein p53

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
CA-21737NCI NIH HHSUnited StatesP01CA021737PubMed and NIHNIH RePORTER
CA-51425NCI NIH HHSUnited StatesR01CA051425PubMed and NIHNIH RePORTER
CA-60437NCI NIH HHSUnited StatesU01CA060437PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References31

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
12,450,350Antigen-independent regulation of cytoplasmic calcium in B cells with a 12-kDa B-cell growth factor and anti-CD19.Proc Natl Acad Sci U S A1988https://conductscience.org/library/papers/2450350PubMed
27,531,365Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinases.Science1995https://conductscience.org/library/papers/7531365PubMed
32,460,871Immunobiologic differences between normal and leukemic human B-cell precursors.Proc Natl Acad Sci U S A1988https://conductscience.org/library/papers/2460871PubMed
42,644,978Leukemic B-cell precursors express functional receptors for human interleukin-3.Blood1989https://conductscience.org/library/papers/2644978PubMed
52,472,450Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily.J Immunol1989https://conductscience.org/library/papers/2472450PubMed
62,790,800Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.Cancer Res1989https://conductscience.org/library/papers/2790800PubMed
72,242,419Regulation of human B-cell ontogeny.Blood1990https://conductscience.org/library/papers/2242419PubMed
82,250,705Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death.Nature1990https://conductscience.org/library/papers/2250705PubMed
91,373,518CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes.Science1992https://conductscience.org/library/papers/1373518PubMed
101,374,445CD19 regulation of human B cell responses. B cell proliferation and antibody secretion are inhibited or enhanced by ligation of the CD19 surface glycoprotein depending on the stimulating signal used.J Immunol1992https://conductscience.org/library/papers/1374445PubMed

1 to 10 of 31

See all 31 references

Cited by6

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 38 citations.

PMIDTitleJournalYearIn PapersSource
42,979,282The CD19-Coupled CD21 is an Essential Receptor for B cell Activation.J Cell Signal2026https://conductscience.org/library/papers/42979282PubMed
25,592,164Gene expression profiling analysis of castration-resistant prostate cancer.Med Sci Monit2015https://conductscience.org/library/papers/25592164PubMed
17,350,876Src kinase signaling in leukaemia.Int J Biochem Cell Biol2007https://conductscience.org/library/papers/17350876PubMed
9,653,091Antiviral protection and germinal center formation, but impaired B cell memory in the absence of CD19.J Exp Med1998https://conductscience.org/library/papers/9653091PubMed
9,430,650Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death.EMBO J1998https://conductscience.org/library/papers/9430650PubMed
8,917,729Role of protein kinase activity in apoptosis.Experientia1996https://conductscience.org/library/papers/8917729PubMed

Genes7

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
BAX581PubTator's text mininghttps://conductscience.org/library/genes/581NCBI Gene
BCL2596PubTator's text mininghttps://conductscience.org/library/genes/596NCBI Gene
CD19930PubTator's text mininghttps://conductscience.org/library/genes/930NCBI Gene
CHMP2A27,243PubTator's text mininghttps://conductscience.org/library/genes/27243NCBI Gene
EPHA82,046PubTator's text mininghttps://conductscience.org/library/genes/2046NCBI Gene
LYN4,067PubTator's text mininghttps://conductscience.org/library/genes/4067NCBI Gene
TP537,157PubTator's text mininghttps://conductscience.org/library/genes/7157NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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