Disease · EFO_0007067

decubitus ulcer

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. decubitus ulcer. Diseases, record EFO_0007067. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/EFO_0007067

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: decubitus ulcer; Open Targets
Open Targets ID: EFO_0007067; Open Targets
Other names: bed sore, pressure sore, pressure ulcer; Open Targets
Disease Ontology: DOID:8717; Disease Ontology
Highest stage of its drugs: Approval, for 1 of its 11 drugs, from DailyMed; Open Targets

Drugs11

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
GLYCERIN	CHEMBL692	Small molecule	Approval	DailyMed	1	0	0	Drugs and targets
COLLAGENASE CLOSTRIDIUM HISTOLYTICUM	CHEMBL2108709	Enzyme	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
OXANDROLONE	CHEMBL1200436	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
PIOGLITAZONE	CHEMBL595	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
THYMOSIN	CHEMBL412531	Protein	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
2-HYDROXYPROPYL-BETA-CYCLODEXTRIN	CHEMBL577294	Oligosaccharide	Phase 1/2	ClinicalTrials.gov	1	1	1	Drugs and targets
INSULIN HUMAN	CHEMBL1201631	Protein	Phase 1/2	ClinicalTrials.gov	1	1	1	Drugs and targets
NITRIC OXIDE	CHEMBL1200689	Small molecule	Phase 1/2	ClinicalTrials.gov	1	1	1	Drugs and targets
MELATONIN	CHEMBL45	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
TETRACHLORODECAOXIDE	CHEMBL6067985	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets

1 to 10 of 11

See all 11 drugs

Targets35

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
ADRB1	Beta-1 adrenergic receptor	1	Beta-1 adrenergic receptor antagonist	Unknown	https://conductscience.org/library/genes/153	Drugs and targets
ADRB2	Beta-2 adrenergic receptor	1	Beta-2 adrenergic receptor antagonist	Unknown	https://conductscience.org/library/genes/154	Drugs and targets
AR	Androgen receptor	1	Androgen Receptor agonist	Phase 3	https://conductscience.org/library/genes/367	Drugs and targets
COL11A1	Collagen	1	Collagen hydrolytic enzyme	Phase 3	https://conductscience.org/library/genes/1301	Drugs and targets
COL11A2	Collagen	1	Collagen hydrolytic enzyme	Phase 3	https://conductscience.org/library/genes/1302	Drugs and targets
COL15A1	Collagen	1	Collagen hydrolytic enzyme	Phase 3	https://conductscience.org/library/genes/1306	Drugs and targets
COL18A1	Collagen	1	Collagen hydrolytic enzyme	Phase 3	https://conductscience.org/library/genes/80781	Drugs and targets
COL1A1	Collagen	1	Collagen hydrolytic enzyme	Phase 3	https://conductscience.org/library/genes/1277	Drugs and targets
COL1A2	Collagen	1	Collagen hydrolytic enzyme	Phase 3	https://conductscience.org/library/genes/1278	Drugs and targets
COL24A1	Collagen	1	Collagen hydrolytic enzyme	Phase 3	https://conductscience.org/library/genes/255631	Drugs and targets

1 to 10 of 35

See all 35 targets

Trials10

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT00101361	Oxandrolone to Heal Pressure Ulcers	Phase 3	212	2013-11-25	Pressure Ulcer	OXANDROLONE	Its record names the disease	ClinicalTrials.gov
NCT00382174	Study of Thymosin Beta 4 in Patients With Pressure Ulcers	Phase 2	72	2010-02-01	Pressure Ulcers	THYMOSIN	Open Targets' reading of its record	ClinicalTrials.gov
NCT02418676	Insulin Complexation With Hydroxypropyl-beta-cyclodextrin: Use of the Complex in Gel for Healing of Pressure Ulcers	Phase 1/2	15	2016-01-14	Pressure Ulcer, Wound	2-HYDROXYPROPYL-BETA-CYCLODEXTRIN, INSULIN HUMAN	Its record names the disease	ClinicalTrials.gov
NCT01208220	Effectiveness Study of Santyl Ointment to Treat Pressure Ulcers	Not applicable	2	2014-07-17	Pressure Ulcer, Soft Tissue Necrosis Lower Limb	COLLAGENASE CLOSTRIDIUM HISTOLYTICUM	Its record names the disease	ClinicalTrials.gov
NCT07096830	Efficacy of Tetrachlorodecaoxide (TCDO) Drops in Chronic Wound Healing	Not applicable	66		Chronic Wound Care	TETRACHLORODECAOXIDE	Open Targets' reading of its record	ClinicalTrials.gov
NCT06421454	Clinical Trial for the Evaluation of Melatonin in the Treatment of Pressure Ulcers	Not applicable	50		Pressure Ulcer	MELATONIN	Its record names the disease	ClinicalTrials.gov
NCT01351493	Study on the Safety and Efficacy of Nitric Oxide Gel in Subjects With Pressure Sore	Phase 1/2	40		Pressure Ulcer	NITRIC OXIDE	Its record names the disease	ClinicalTrials.gov
NCT04903366	Absorption and Safety of Topical Timolol to Treat Chronic Wounds		40		Glaucoma, Open-Angle, Chronic Wounds	TIMOLOL	Its record names the disease	ClinicalTrials.gov
NCT02004626	Evaluate the Noninferiority of Medicines Treating Uninfected Pressure Ulcers.	Phase 3	0		Pressure Ulcer	COLLAGENASE CLOSTRIDIUM HISTOLYTICUM	Its record names the disease	ClinicalTrials.gov
NCT02585765	Skin Blood Flow Response to Insulin Iontophoresis in Pressure Ulcers of SCI	Phase 2	0		Spinal Cord Injury, Pressure Ulcers	PIOGLITAZONE	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials3

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
1 Oxandrolone vs 2 Placebo: A Healed Pressure Ulcer	26 of 108	31 of 104	212	NCT00101361	Trial comparisons
1 Oxandrolone vs 2 Placebo: serious adverse events	9 of 108	16 of 104	212	NCT00101361	Trial comparisons
Negative Pressure Wound Therapy vs Santyl Ointment and NPWT: serious adverse events	0 of 1	0 of 1	2	NCT01208220	Trial comparisons

Papers from its trials1

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it
23689765	DERIVED	1

Source PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/EFO_0007067

GET https://conductscience.org/api/diseases/v1/EFO_0007067/targets?page=2

API reference For AI assistants