Disease · MONDO_0004169
premenstrual tension
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. premenstrual tension. Diseases, record MONDO_0004169. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0004169
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
- Highest stage of its drugs
- Phase 3, for 8 of its 16 drugs, from ClinicalTrials.gov and TTD
- Open Targets
Drugs16
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| FLUOXETINE | CHEMBL41 | Small molecule | Phase 3 | ClinicalTrials.gov | 4 | 4 | 4 | Drugs and targets |
| DROSPIRENONE | CHEMBL1509 | Small molecule | Phase 3 | ClinicalTrials.gov | 2 | 2 | 2 | Drugs and targets |
| ETHINYL ESTRADIOL | CHEMBL691 | Small molecule | Phase 3 | ClinicalTrials.gov | 2 | 2 | 1 | Drugs and targets |
| DIENOGEST | CHEMBL1201864 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| ESTRONE | CHEMBL1405 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| HYPERICIN | CHEMBL286494 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| NUX VOMICA EXTRACT | CHEMBL2107927 | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets | |
| ELTANOLONE | CHEMBL210952 | Small molecule | Phase 3 | TTD | 1 | 0 | 0 | Drugs and targets |
| SERTRALINE | CHEMBL809 | Small molecule | Phase 1/2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| PROGESTERONE | CHEMBL103 | Small molecule | Phase 1 | ClinicalTrials.gov | 2 | 2 | 2 | Drugs and targets |
1 to 10 of 16
See all 16 drugsTargets7
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| ESR1 | Estrogen receptor | 3 | Estrogen receptor alpha agonist | Phase 3 | https://conductscience.org/library/genes/2099 | Drugs and targets |
| PGR | Progesterone receptor | 2 | Progesterone receptor agonist | Phase 3 | https://conductscience.org/library/genes/5241 | Drugs and targets |
| PTGS1 | Cyclooxygenase | 2 | Cyclooxygenase inhibitor | Unknown | https://conductscience.org/library/genes/5742 | Drugs and targets |
| PTGS2 | Cyclooxygenase | 2 | Cyclooxygenase inhibitor | Unknown | https://conductscience.org/library/genes/5743 | Drugs and targets |
| SLC6A4 | Sodium-dependent serotonin transporter | 2 | Serotonin transporter inhibitor | Phase 3 | https://conductscience.org/library/genes/6532 | Drugs and targets |
| GNRHR | Gonadotropin-releasing hormone receptor | 1 | Gonadotropin-releasing hormone receptor agonist | Phase 1 | https://conductscience.org/library/genes/2798 | Drugs and targets |
| NR3C2 | Mineralocorticoid receptor | 1 | Mineralocorticoid receptor antagonist | Phase 3 | https://conductscience.org/library/genes/4306 | Drugs and targets |
Trials9
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 1 more is not shown, since the checks do not confirm it.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT00001259 | A Treatment Study for Premenstrual Syndrome (PMS) | Phase 1 | 60 | 2023-03-02 | Premenstrual Syndrome, Menstruation Disturbances | ESTRADIOL, LEUPROLIDE ACETATE, PROGESTERONE | Its record names the disease | ClinicalTrials.gov |
| NCT00965562 | Comparison of Fluoxetine, Calcium and Placebo for the Treatment of Moderate to Severe Premenstrual Syndrome (PMS) | Not applicable | 49 | 2015-02-26 | Premenstrual Syndrome | CALCIUM CARBONATE, FLUOXETINE | Its record names the disease | ClinicalTrials.gov |
| NCT02488538 | Combined Oral Contraceptives and Fluoxetine Versus Combined Oral Contraceptives in Severe Premenstrual Syndrome | Phase 3 | 300 | Premenstrual Syndrome | DROSPIRENONE, FLUOXETINE | Its record names the disease | ClinicalTrials.gov | |
| NCT02562053 | Does Adding Oral Contraceptives to Fluoxetine Improve the Management of Premenstrual Syndrome? | Phase 3 | 300 | Premenstrual Syndrome | DROSPIRENONE, ETHINYL ESTRADIOL, FLUOXETINE | Its record names the disease | ClinicalTrials.gov | |
| NCT01365676 | GAMALINE®+HIPERICIN® for PMS Treatment and Vasomotor Symptoms | Phase 3 | 240 | Premenstrual Syndrome, Uterus; Hemorrhage, Preclimacteric or Premenopausal | HYPERICIN | Its record names the disease | ClinicalTrials.gov | |
| NCT02427334 | Dienogest Versus Luteal Phase Fluoxetine in the Management of Premenstrual Syndrome | Phase 3 | 210 | Premenstrual Syndrome | DIENOGEST, FLUOXETINE | Its record names the disease | ClinicalTrials.gov | |
| NCT02402049 | Homeopathic Treatment of Premenstrual Syndrome | Phase 3 | 180 | Premenstrual Syndrome-PMS | ESTRONE, NUX VOMICA EXTRACT | Its record names the disease | ClinicalTrials.gov | |
| NCT03881319 | The Efficacy of Different Doses of Acupuncture in Dysmenorrhea | Not applicable | 105 | Premenstrual Syndrome, Dysmenorrhea | PROGESTERONE | Its record names the disease | ClinicalTrials.gov | |
| NCT00048854 | Antidepressant Treatment for Premenstrual Syndrome and Premenstrual Dysphoric Disorder | Phase 1/2 | 66 | Premenstrual Syndrome | SERTRALINE | Its record names the disease | ClinicalTrials.gov |
Comparisons in its trials0
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
None in this release.
Papers from its trials4
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/MONDO_0004169
GET https://conductscience.org/api/diseases/v1/MONDO_0004169/drugs