Disease · MONDO_0004782
diabetes insipidus
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. diabetes insipidus. Diseases, record MONDO_0004782. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0004782
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
Drugs5
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| VASOPRESSIN | CHEMBL373742 | Protein | Approval | DailyMed and TTD | 7 | 0 | 0 | Drugs and targets |
| DESMOPRESSIN ACETATE | CHEMBL1200556 | Protein | Approval | DailyMed and PMDA | 4 | 0 | 0 | Drugs and targets |
| DESMOPRESSIN | CHEMBL1429 | Protein | Phase 3 | ClinicalTrials.gov | 3 | 3 | 3 | Drugs and targets |
| DANTROLENE SODIUM | CHEMBL928 | Small molecule | Phase 1/2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| CHLORPROPAMIDE | CHEMBL498 | Small molecule | Unknown | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
Targets7
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| AVPR1A | Vasopressin receptor | 3 | Vasopressin receptor agonist | Approval | https://conductscience.org/library/genes/552 | Drugs and targets |
| AVPR1B | Vasopressin receptor | 3 | Vasopressin receptor agonist | Approval | https://conductscience.org/library/genes/553 | Drugs and targets |
| AVPR2 | Vasopressin receptor | 3 | Vasopressin receptor agonist | Approval | https://conductscience.org/library/genes/554 | Drugs and targets |
| ABCC8 | Sulfonylurea receptor 1, Kir6.2 | 1 | Sulfonylurea receptor 1, Kir6.2 blocker | Unknown | https://conductscience.org/library/genes/6833 | Drugs and targets |
| KCNJ11 | Sulfonylurea receptor 1, Kir6.2 | 1 | Sulfonylurea receptor 1, Kir6.2 blocker | Unknown | https://conductscience.org/library/genes/3767 | Drugs and targets |
| RYR1 | Ryanodine receptor 1 | 1 | Ryanodine receptor 1 antagonist | Phase 1/2 | https://conductscience.org/library/genes/6261 | Drugs and targets |
| RYR3 | Ryanodine receptor 3 | 1 | Ryanodine receptor 3 antagonist | Phase 1/2 | https://conductscience.org/library/genes/6263 | Drugs and targets |
Trials4
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT02829268 | A Clinical Trial of Dantrolene Sodium in Pediatric and Adult Patients With Wolfram Syndrome | Phase 1/2 | 21 | 2024-03-13 | Wolfram Syndrome, Diabetes Mellitus, Optic Nerve Atrophy, Ataxia | DANTROLENE SODIUM | Its record names the disease | ClinicalTrials.gov |
| NCT01280188 | A Study of Minirin Melt in Japanese Patients With Central Diabetes Insipidus (CDI). | Phase 3 | 20 | Central Diabetes Insipidus | DESMOPRESSIN | Open Targets' reading, confirmed by NLM's indexing of its papers | ClinicalTrials.gov | |
| NCT00004364 | Study of Novel Types of Familial Diabetes Insipidus | 5 | Diabetes Insipidus | DESMOPRESSIN | Its record names the disease | ClinicalTrials.gov | ||
| NCT00004363 | Study of the Pathogenesis and Pathophysiology of Familial Neurohypophyseal Diabetes Insipidus | Diabetes Insipidus, Diabetes Insipidus, Neurohypophyseal | CHLORPROPAMIDE, DESMOPRESSIN | Its record names the disease | ClinicalTrials.gov |
Comparisons in its trials2
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| Pediatric vs Adult: deaths from any cause | 0 of 8 | 0 of 11 | 19 | NCT02829268 | Trial comparisons |
| Pediatric vs Adult: serious adverse events | 0 of 8 | 0 of 11 | 19 | NCT02829268 | Trial comparisons |
Papers from its trials2
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/MONDO_0004782
GET https://conductscience.org/api/diseases/v1/MONDO_0004782/drugs