Disease · MONDO_0024279

chronic endometritis

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. chronic endometritis. Diseases, record MONDO_0024279. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0024279

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: chronic endometritis; Open Targets
Open Targets ID: MONDO_0024279; Open Targets
Other names: endometritis, chronic; Open Targets
NCI Thesaurus: C102820; NCI Thesaurus
Highest stage of its drugs: Phase 1/2, for 2 of its 6 drugs, from ClinicalTrials.gov; Open Targets

Drugs6

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
DOXYCYCLINE	CHEMBL1200699	Small molecule	Phase 1/2	ClinicalTrials.gov	2	2	2	Drugs and targets
BERBERINE	CHEMBL295124	Small molecule	Phase 1/2	ClinicalTrials.gov	1	1	1	Drugs and targets
LEVOFLOXACIN	CHEMBL5315124	Small molecule	Unknown	ClinicalTrials.gov	2	2	2	Drugs and targets
MEDROXYPROGESTERONE ACETATE	CHEMBL717	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
METRONIDAZOLE	CHEMBL137	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
TINIDAZOLE	CHEMBL1220	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets

Targets5

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
MMP1	Interstitial collagenase	1	Matrix metalloproteinase-1 inhibitor	Phase 1/2	https://conductscience.org/library/genes/4312	Drugs and targets
MMP13	Collagenase 3	1	Matrix metalloproteinase 13 inhibitor	Phase 1/2	https://conductscience.org/library/genes/4322	Drugs and targets
MMP7	Matrilysin	1	Matrix metalloproteinase 7 inhibitor	Phase 1/2	https://conductscience.org/library/genes/4316	Drugs and targets
MMP8	Neutrophil collagenase	1	Matrix metalloproteinase 8 inhibitor	Phase 1/2	https://conductscience.org/library/genes/4317	Drugs and targets
PGR	Progesterone receptor	1	Progesterone receptor agonist	Unknown	https://conductscience.org/library/genes/5241	Drugs and targets

Trials4

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT02648698	RCT(Randomized Clinical Trial ) of Antibiotic Therapy in Chronic Endometritis	Not applicable	120	2020-06-04	Chronic Endometritis	LEVOFLOXACIN, TINIDAZOLE	Its record names the disease	ClinicalTrials.gov
NCT07488949	Doxycycline and Progestin Therapy for Chronic Endometritis(CE) in Patients With Recurrent Reproductive Failure(RRF)	Not applicable	1,000		Chronic Endometritis	DOXYCYCLINE, MEDROXYPROGESTERONE ACETATE	Its record names the disease	ClinicalTrials.gov
NCT06650540	Levofloxacin Plus Metronidazole Suppositories Versus Levofloxacin Co-administered with Metronidazole Tablets in Chronic Endometritis	Not applicable	800		IVF	LEVOFLOXACIN, METRONIDAZOLE	Its record names the disease	ClinicalTrials.gov
NCT07180563	Randomized Controlled Trial of Berberine in Combination With Doxycycline in the Treatment of Chronic Endometritis	Phase 1/2	206		Chronic Endometritis	BERBERINE, DOXYCYCLINE	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials2

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Antibiotic Group vs Control Group: deaths from any cause	0 of 59	0 of 55	114	NCT02648698	Trial comparisons
Antibiotic Group vs Control Group: serious adverse events	0 of 59	0 of 55	114	NCT02648698	Trial comparisons

Papers from its trials10

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
38358731	RESULT	1	PubMed
35621273	RESULT	1	PubMed
33663485	RESULT	1	PubMed
33501741	RESULT	1	PubMed
31926918	RESULT	1	PubMed
26207958	RESULT	1	PubMed
25385744	RESULT	1	PubMed
24462055	RESULT	1	PubMed
40954081	DERIVED	1	PubMed
33549312	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0024279

GET https://conductscience.org/api/diseases/v1/MONDO_0024279/drugs

API reference For AI assistants