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Paper · 24650449

Chronic stress accelerates pancreatic cancer growth and invasion: a critical role for beta-adrenergic signaling in the pancreatic microenvironment.

Kim-Fuchs C and 7 others. Brain Behav Immun, 2014. Cited by 236 papers, by iCite.

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ConductScience Library. Chronic stress accelerates pancreatic cancer growth and invasion: a critical role for beta-adrenergic signaling in the pancreatic microenvironment. Papers, record 24650449. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/24650449

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Chronic stress accelerates pancreatic cancer growth and invasion: a critical role for beta-adrenergic signaling in the pancreatic microenvironment.
PubMed
Journal
Brain Behav Immun
PubMed
Year
2014
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
236
iCite
Relative citation ratio, by iCite
6.7
iCite
Revised in PubMed
2021-10-21
PubMed

Authors8

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Kim-Fuchs CCorina
2Le CPCaroline P
3Pimentel MAMatthew A
4Shackleford DDavid
5Ferrari DDavide
6Angst EEliane
7Hollande FFrédéric
8Sloan EKErica K

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
PancreasMajor topic
Pancreatic NeoplasmsMajor topic
Receptors, Adrenergic, betaMajor topic
Stress, PsychologicalMajor topic
Sympathetic Nervous SystemMajor topic
Adrenergic beta-Agonists
Adrenergic beta-Antagonists
Animals
Cell Line, Tumor
Chronic Disease
Cyclic AMP
Disease Progression
Humans
Mice
Mice, Inbred BALB C
Restraint, Physical
Signal Transduction

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
R01 CA160890NCI NIH HHSUnited StatesR01CA160890PubMed and NIH
CA160890NCI NIH HHSUnited StatesR01CA160890PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References59

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
111,180,574The prevalence of psychological distress by cancer site.Psychooncology2001https://conductscience.org/library/papers/11180574PubMed
220,424,515β2-adrenergic antagonists suppress pancreatic cancer cell invasion by inhibiting CREB, NFκB and AP-1.Cancer Biol Ther2010https://conductscience.org/library/papers/20424515PubMed
318,289,016Repeated restraint and nerve growth factor administration in male and female mice: effect on sympathetic and cardiovascular mediators of the stress response.Curr Neurovasc Res2008https://conductscience.org/library/papers/18289016PubMed
417,452,677Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group.J Clin Oncol2007https://conductscience.org/library/papers/17452677PubMed
515,711,560Lentiviral vector retargeting to P-glycoprotein on metastatic melanoma through intravenous injection.Nat Med2005https://conductscience.org/library/papers/15711560PubMed
619,212,120Resection of primary pancreatic cancer and liver metastasis: a systematic review.Dig Surg2008https://conductscience.org/library/papers/19212120PubMed
722,991,414Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors.Clin Cancer Res2012https://conductscience.org/library/papers/22991414PubMed
819,724,861Norepinephrine-induced invasion by pancreatic cancer cells is inhibited by propranolol.Oncol Rep2009https://conductscience.org/library/papers/19724861PubMed
97,676,716Aggressive surgery for pancreatic duct cell cancer: feasibility, validity, limitations.World J Surg1995https://conductscience.org/library/papers/7676716PubMed
1022,353,526Beta-adrenoceptor action on pancreatic cancer cell proliferation and tumor growth in mice.Hepatogastroenterology2012https://conductscience.org/library/papers/22353526PubMed

1 to 10 of 59

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Cited by174

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 236 citations.

PMIDTitleJournalYearIn PapersSource
42,941,861Molecular Targeting of the Peripheral Nerve-Tumor Axis in Extracranial Solid Cancers: Eight Signaling Systems, One Effect-Systematic Review and Multilevel Meta-Analysis.Int J Mol Sci2026https://conductscience.org/library/papers/42941861PubMed
42,838,935Neuro-immune interactions in tumors, immune-related disorders, and infections.Signal Transduct Target Ther2026https://conductscience.org/library/papers/42838935PubMed
42,774,376Stress Biology in Cancer: Neuroendocrine-Immune Mechanisms Linking Tumor Progression to Translational Interventions.Cancer Commun (Lond)2026https://conductscience.org/library/papers/42774376PubMed
42,734,679Neural regulation of cancer: from microenvironmental hijacking to systemic circuit co-option.Cell Oncol (Dordr)2026https://conductscience.org/library/papers/42734679PubMed
42,464,935Pancreatic cancer cachexia promotes cardiac dysfunction through altered adrenergic signalling in the heart.J Physiol2026https://conductscience.org/library/papers/42464935PubMed
42,440,988Biological and Pathophysiological Mechanisms of Postoperative Complications Affecting Long-Term Survival: A Narrative Review.Cureus2026https://conductscience.org/library/papers/42440988PubMed
42,066,073Chronic stress disrupts hepatic homeostasis and accelerates liver cancer progression through ADRB2 signaling.Sci Adv2026https://conductscience.org/library/papers/42066073PubMed
41,938,710Understanding nerve-tumor interactions: From basic biology to therapeutic innovation.Genes Dis2026https://conductscience.org/library/papers/41938710PubMed
41,909,437Preventive Role and Survival Benefit of Beta Blockers in Pancreatic Cancer: A Systematic Review and Meta-Analysis of Observational Studies.Cureus2026https://conductscience.org/library/papers/41909437PubMed
41,906,691Nebivolol prevents exhausted T cells and enhances cytotoxicity against MCF-7 breast cancer cells in a β2-adrenergic receptor-dependent manner.Clin Exp Immunol2026https://conductscience.org/library/papers/41906691PubMed

1 to 10 of 174

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Genes11

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ADRB1153PubTator's text mininghttps://conductscience.org/library/genes/153NCBI Gene
ADRB2154PubTator's text mininghttps://conductscience.org/library/genes/154NCBI Gene
EGFR1,956PubTator's text mininghttps://conductscience.org/library/genes/1956NCBI Gene
FOXN18,456PubTator's text mininghttps://conductscience.org/library/genes/8456NCBI Gene
INS3,630PubTator's text mininghttps://conductscience.org/library/genes/3630NCBI Gene
KRAS3,845PubTator's text mininghttps://conductscience.org/library/genes/3845NCBI Gene
MMP24,313PubTator's text mininghttps://conductscience.org/library/genes/4313NCBI Gene
MMP94,318PubTator's text mininghttps://conductscience.org/library/genes/4318NCBI Gene
RPL306,156PubTator's text mininghttps://conductscience.org/library/genes/6156NCBI Gene
TP537,157PubTator's text mininghttps://conductscience.org/library/genes/7157NCBI Gene

1 to 10 of 11

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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