Paper · 26317527

Effects of Estrogens on Adipokines and Glucose Homeostasis in Female Aromatase Knockout Mice.

Van Sinderen ML and 10 others. PLoS One, 2015. Cited by 24 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Effects of Estrogens on Adipokines and Glucose Homeostasis in Female Aromatase Knockout Mice. Papers, record 26317527. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/26317527

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Effects of Estrogens on Adipokines and Glucose Homeostasis in Female Aromatase Knockout Mice.; PubMed
Journal: PLoS One; PubMed
Year: 2015; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/26317527/; PubMed
DOI: https://doi.org/10.1371/journal.pone.0136143; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC4552801/; PubMed
The journal: https://conductscience.org/library/journal-index/101285081; PubMed
Citations, by iCite: 24; iCite
Relative citation ratio, by iCite: 0.9; iCite
Revised in PubMed: 2018-11-13; PubMed

Authors11

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Van Sinderen ML	Michelle L
2	Steinberg GR	Gregory R
3	Jørgensen SB	Sebastian B
4	Honeyman J	Jane
5	Chow JD	Jenny D
6	Herridge KA	Kerrie A
7	Winship AL	Amy L
8	Dimitriadis E	Evdokia
9	Jones ME	Margaret E E
10	Simpson ER	Evan R

1 to 10 of 11Source PubMed

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Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Adipokines	Major topic
Aromatase	Major topic
Estradiol	Major topic
Estrogens	Major topic
Gluconeogenesis	Major topic
Glucose	Major topic
Homeostasis	Major topic
Adipose Tissue
Animals
Female
Interleukin-6
Leptin
Liver
Mice
Mice, Inbred C57BL
Muscle, Skeletal
Triglycerides
Tumor Necrosis Factor-alpha

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References45

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	16,091,493	A unique role of monocyte chemoattractant protein 1 among chemokines in adipose tissue of obese subjects.	J Clin Endocrinol Metab	2005	https://conductscience.org/library/papers/16091493	PubMed
2	10,448,530	Regulation of glucose production by the liver.	Annu Rev Nutr	1999	https://conductscience.org/library/papers/10448530	PubMed
3	16,480,891	Of mice and men: the evolving phenotype of aromatase deficiency.	Trends Endocrinol Metab	2006	https://conductscience.org/library/papers/16480891	PubMed
4	16,766,431	Adipose tissue, insulin resistance and low-grade inflammation: implications for atherogenesis and the cardiovascular harm of estrogen plus progestogen therapy.	Climacteric	2006	https://conductscience.org/library/papers/16766431	PubMed
5	16,918,948	Insulin resistance, endocrine function and adipokines in type 2 diabetes patients at different glycaemic levels: potential impact for glucotoxicity in vivo.	Clin Endocrinol (Oxf)	2006	https://conductscience.org/library/papers/16918948	PubMed
6	17,554,339	Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator.	Nature	2007	https://conductscience.org/library/papers/17554339	PubMed
7	17,640,948	The complex role of estrogens in inflammation.	Endocr Rev	2007	https://conductscience.org/library/papers/17640948	PubMed
8	18,701,022	Variations of tumor necrosis factor-alpha, leptin and adiponectin in mid-trimester of gestational diabetes mellitus.	Chin Med J (Engl)	2008	https://conductscience.org/library/papers/18701022	PubMed
9	18,561,209	Regulation of hepatic glucose production and the role of gluconeogenesis in humans: is the rate of gluconeogenesis constant?	Diabetes Metab Res Rev	2008	https://conductscience.org/library/papers/18561209	PubMed
10	19,136,652	Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism.	Diabetes	2009	https://conductscience.org/library/papers/19136652	PubMed

1 to 10 of 45

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Cited by13

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 24 citations.

PMID	Title	Journal	Year	In Papers	Source
42,945,313	Imaging [18F]FDG PET/CT pilot study of nicotinic acetylcholinergic receptor α2 knock-out mice and α2 hypersensitive mice compared to control mice: Male-female differences and nicotine effects.	PLoS One	2026	https://conductscience.org/library/papers/42945313	PubMed
41,697,840	Congenital vs adult-onset estrogen deficiency in female mice: physiological effects and implications for therapy.	J Endocrinol	2026	https://conductscience.org/library/papers/41697840	PubMed
36,979,669	Estrogens in Adipose Tissue Physiology and Obesity-Related Dysfunction.	Biomedicines	2023	https://conductscience.org/library/papers/36979669	PubMed
36,712,262	Associations between endogenous sex hormone levels and adipokine levels in the Multi-Ethnic Study of Atherosclerosis.	Front Cardiovasc Med	2022	https://conductscience.org/library/papers/36712262	PubMed
35,721,736	The Regulation of Adipose Tissue Health by Estrogens.	Front Endocrinol (Lausanne)	2022	https://conductscience.org/library/papers/35721736	PubMed
34,474,078	Age and Sex: Impact on adipose tissue metabolism and inflammation.	Mech Ageing Dev	2021	https://conductscience.org/library/papers/34474078	PubMed
34,436,440	Distinct Changes in Gut Microbiota Are Associated with Estradiol-Mediated Protection from Diet-Induced Obesity in Female Mice.	Metabolites	2021	https://conductscience.org/library/papers/34436440	PubMed
31,847,105	Breast-Associated Adipocytes Secretome Induce Fatty Acid Uptake and Invasiveness in Breast Cancer Cells via CD36 Independently of Body Mass Index, Menopausal Status and Mammary Density.	Cancers (Basel)	2019	https://conductscience.org/library/papers/31847105	PubMed
31,713,639	Dehydroepiandrosterone on metabolism and the cardiovascular system in the postmenopausal period.	J Mol Med (Berl)	2020	https://conductscience.org/library/papers/31713639	PubMed
30,211,334	Lack of 17β-estradiol reduces sensitivity to insulin in the liver and muscle of male mice.	Heliyon	2018	https://conductscience.org/library/papers/30211334	PubMed

1 to 10 of 13

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Genes9

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
ADIPOQ	9,370	PubTator's text mining	https://conductscience.org/library/genes/9370	NCBI Gene
CYP19A1	1,588	PubTator's text mining	https://conductscience.org/library/genes/1588	NCBI Gene
GCG	2,641	PubTator's text mining	https://conductscience.org/library/genes/2641	NCBI Gene
IL6	3,569	PubTator's text mining	https://conductscience.org/library/genes/3569	NCBI Gene
INS	3,630	PubTator's text mining	https://conductscience.org/library/genes/3630	NCBI Gene
LEP	3,952	PubTator's text mining	https://conductscience.org/library/genes/3952	NCBI Gene
NAMPT	10,135	PubTator's text mining	https://conductscience.org/library/genes/10135	NCBI Gene
RETN	56,729	PubTator's text mining	https://conductscience.org/library/genes/56729	NCBI Gene
TNF	7,124	PubTator's text mining	https://conductscience.org/library/genes/7124	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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