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Paper · 29975751

PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition.

McNeill RS and 11 others. PLoS One, 2018. Cited by 21 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition. Papers, record 29975751. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/29975751

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition.
PubMed
Journal
PLoS One
PubMed
Year
2018
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
21
iCite
Relative citation ratio, by iCite
0.79
iCite
Revised in PubMed
2020-11-05
PubMed

Authors12

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1McNeill RSRobert S
2Stroobant EEEmily E
3Smithberger EErin
4Canoutas DADemitra A
5Butler MKMadison K
6Shelton AKAbigail K
7Patel SDShrey Dhttps://orcid.org/0000-0001-5008-7616
8Limas JCJuanita Chttps://orcid.org/0000-0001-6384-8787
9Skinner KRKasey R
10Bash RERyan E

1 to 10 of 12Source PubMed

See all 12 authors

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Class I Phosphatidylinositol 3-KinasesMajor topic
GlioblastomaMajor topic
Mutation, MissenseMajor topic
Astrocytes
Carcinogenesis
Cell Movement
Cell Proliferation
Cell Transformation, Neoplastic
Drug Synergism
Enzyme Activation
Humans
Mitogen-Activated Protein Kinases
Protein Kinase Inhibitors

Source PubMed

Grants6

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
T32 NS007431NINDS NIH HHSUnited StatesT32NS007431PubMed and NIHNIH RePORTER
P30 ES010126NIEHS NIH HHSUnited StatesP30ES010126PubMed and NIHNIH RePORTER
R01 CA204136NCI NIH HHSUnited StatesR01CA204136PubMed and NIHNIH RePORTER
UL1 TR001111NCATS NIH HHSUnited StatesUL1TR001111PubMed and NIHNIH RePORTER
P30 CA016086NCI NIH HHSUnited StatesP30CA016086PubMed and NIHNIH RePORTER
T32 GM122741NIGMS NIH HHSUnited StatesT32GM122741PubMedNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References55

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
121,397,855Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brain.Cancer Cell2011https://conductscience.org/library/papers/21397855PubMed
220,379,207The emerging mechanisms of isoform-specific PI3K signalling.Nat Rev Mol Cell Biol2010https://conductscience.org/library/papers/20379207PubMed
326,826,202Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide.Neuro Oncol2016https://conductscience.org/library/papers/26826202PubMed
427,157,931The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.Acta Neuropathol2016https://conductscience.org/library/papers/27157931PubMed
522,500,798Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer.Cell2012https://conductscience.org/library/papers/22500798PubMed
625,146,643Modeling astrocytoma pathogenesis in vitro and in vivo using cortical astrocytes or neural stem cells from conditional, genetically engineered mice.J Vis Exp2014https://conductscience.org/library/papers/25146643PubMed
724,076,665Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities.Nat Med2013https://conductscience.org/library/papers/24076665PubMed
824,481,312PI3K and cancer: lessons, challenges and opportunities.Nat Rev Drug Discov2014https://conductscience.org/library/papers/24481312PubMed
911,559,533Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma.Cancer Res2001https://conductscience.org/library/papers/11559533PubMed
1023,940,356Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies.Proc Natl Acad Sci U S A2013https://conductscience.org/library/papers/23940356PubMed

1 to 10 of 55

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Cited by19

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 21 citations.

PMIDTitleJournalYearIn PapersSource
42,278,221Potential Association of BRAF and PIK3CA Copy Number Alterations with Long-Term Survival in IDH-Wildtype Glioblastoma: A Pilot Study.Int J Mol Sci2026https://conductscience.org/library/papers/42278221PubMed
40,581,663Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma.Acta Neuropathol Commun2025https://conductscience.org/library/papers/40581663PubMed
40,508,087PIK3CA Mutations: Are They a Relevant Target in Adult Diffuse Gliomas?Int J Mol Sci2025https://conductscience.org/library/papers/40508087PubMed
39,906,820Discovery of mutated oncodriver genes associated with glioblastoma originated from stem cells of subventricular zone through whole exome sequence profile analysis, and drug repurposing.Heliyon2025https://conductscience.org/library/papers/39906820PubMed
38,778,164Arginines of the CGN codon family are Achilles' heels of cancer genes.Sci Rep2024https://conductscience.org/library/papers/38778164PubMed
38,674,026Potential Diagnostic and Clinical Significance of Selected Genetic Alterations in Glioblastoma.Int J Mol Sci2024https://conductscience.org/library/papers/38674026PubMed
36,844,882Recent advances in label-free optical, electrochemical, and electronic biosensors for glioma biomarkers.Biomicrofluidics2023https://conductscience.org/library/papers/36844882PubMed
36,065,261The In Vitro Effect of Psoralen on Glioma Based on Network Pharmacology and Potential Target Research.Evid Based Complement Alternat Med2022https://conductscience.org/library/papers/36065261PubMed
34,771,425Potential Diagnostic Value of the Differential Expression of Histone H3 Variants between Low- and High-Grade Gliomas.Cancers (Basel)2021https://conductscience.org/library/papers/34771425PubMed
34,423,267Fishing for Contact: Modeling Perivascular Glioma Invasion in the Zebrafish Brain.ACS Pharmacol Transl Sci2021https://conductscience.org/library/papers/34423267PubMed

1 to 10 of 19

See all 19 cited by

Genes7

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
AKT1207PubTator's text mininghttps://conductscience.org/library/genes/207NCBI Gene
PIK3CA5,290PubTator's text mininghttps://conductscience.org/library/genes/5290NCBI Gene
PIK3CG5,294PubTator's text mininghttps://conductscience.org/library/genes/5294NCBI Gene
PIK3R15,295PubTator's text mininghttps://conductscience.org/library/genes/5295NCBI Gene
PTEN5,728PubTator's text mininghttps://conductscience.org/library/genes/5728NCBI Gene
RET5,979PubTator's text mininghttps://conductscience.org/library/genes/5979NCBI Gene
TP537,157PubTator's text mininghttps://conductscience.org/library/genes/7157NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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