Disease · EFO_1001909

Plantar Fasciitis

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. Plantar Fasciitis. Diseases, record EFO_1001909. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/EFO_1001909

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: Plantar Fasciitis; Open Targets
Open Targets ID: EFO_1001909; Open Targets
Other names: Chronic Plantar Fasciitis, Heel Spur Syndrome, Plantar Heel Spur, Plantar Heel Spurs, Policeman's Heel; Open Targets
MeSH: D036981; MeSH
Highest stage of its drugs: Phase 2/3, for 12 of its 23 drugs, from ClinicalTrials.gov; Open Targets

Drugs23

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
DEXAMETHASONE	CHEMBL384467	Small molecule	Phase 2/3	ClinicalTrials.gov	7	7	3	Drugs and targets
METHYLPREDNISOLONE	CHEMBL650	Small molecule	Phase 2/3	ClinicalTrials.gov	7	7	3	Drugs and targets
ONABOTULINUMTOXINA	CHEMBL1201574		Phase 2/3	ClinicalTrials.gov	5	5	0	Drugs and targets
BETAMETHASONE	CHEMBL632	Small molecule	Phase 2/3	ClinicalTrials.gov	4	4	0	Drugs and targets
BETAMETHASONE DIPROPIONATE	CHEMBL1200384	Small molecule	Phase 2/3	ClinicalTrials.gov	4	4	0	Drugs and targets
BETAMETHASONE SODIUM PHOSPHATE	CHEMBL1200762	Small molecule	Phase 2/3	ClinicalTrials.gov	4	4	0	Drugs and targets
METHYLPREDNISOLONE ACETATE	CHEMBL1364144	Small molecule	Phase 2/3	ClinicalTrials.gov	4	4	0	Drugs and targets
PREDNISOLONE	CHEMBL131	Small molecule	Phase 2/3	ClinicalTrials.gov	4	4	0	Drugs and targets
PREDNISONE	CHEMBL635	Small molecule	Phase 2/3	ClinicalTrials.gov	4	4	0	Drugs and targets
TRIAMCINOLONE	CHEMBL1451	Small molecule	Phase 2/3	ClinicalTrials.gov	4	4	0	Drugs and targets

1 to 10 of 23

See all 23 drugs

Targets37

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
NR3C1	Glucocorticoid receptor	11	Glucocorticoid receptor agonist	Phase 2/3	https://conductscience.org/library/genes/2908	Drugs and targets
SNAP25	Synaptosomal-associated protein 25	5	Synaptosomal nerve-associated protein 25 (SNAP-25) hydrolytic enzyme; Synaptosomal nerve-associated protein 25 (SNAP-25) inhibitor	Phase 2/3	https://conductscience.org/library/genes/6616	Drugs and targets
SCN4A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker; Sodium channel protein type IV alpha subunit blocker	Phase 1	https://conductscience.org/library/genes/6329	Drugs and targets
COL11A1	Collagen	1	Collagen hydrolytic enzyme	Phase 2	https://conductscience.org/library/genes/1301	Drugs and targets
COL11A2	Collagen	1	Collagen hydrolytic enzyme	Phase 2	https://conductscience.org/library/genes/1302	Drugs and targets
COL15A1	Collagen	1	Collagen hydrolytic enzyme	Phase 2	https://conductscience.org/library/genes/1306	Drugs and targets
COL18A1	Collagen	1	Collagen hydrolytic enzyme	Phase 2	https://conductscience.org/library/genes/80781	Drugs and targets
COL1A1	Collagen	1	Collagen hydrolytic enzyme	Phase 2	https://conductscience.org/library/genes/1277	Drugs and targets
COL1A2	Collagen	1	Collagen hydrolytic enzyme	Phase 2	https://conductscience.org/library/genes/1278	Drugs and targets
COL24A1	Collagen	1	Collagen hydrolytic enzyme	Phase 2	https://conductscience.org/library/genes/255631	Drugs and targets

1 to 10 of 37

See all 37 targets

Trials13

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 7 more are not shown, since the checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT03825315	DaxibotulinumtoxinA for Injection for the Treatment of Plantar Fasciitis	Phase 2	155	2023-09-21	Plantar Fasciitis	DAXIBOTULINUMTOXINA	Its record names the disease	ClinicalTrials.gov
NCT04709484	Comparison of the Effectiveness of USG and Palpation Guidance Steroid Injection in Patients With Plantar Fasciitis	Not applicable	66	2021-10-20	Plantar Fasciitis	LIDOCAINE, METHYLPREDNISOLONE	Its record names the disease	ClinicalTrials.gov
NCT03137407	Phase 2 DaxibotulinumtoxinA for Injection for the Management of Plantar Fasciitis	Phase 2	59	2023-08-28	Plantar Fasciitis	DAXIBOTULINUMTOXINA	Its record names the disease	ClinicalTrials.gov
NCT02973269	DaxibotulinumtoxinA for Injection for the Management of Plantar Fasciitis	Phase 2	7	2024-04-03	Plantar Fasciitis	DAXIBOTULINUMTOXINA	Its record names the disease	ClinicalTrials.gov
NCT06169319	A Study to Assess Collagenase Clostridium Histolyticum (CCH) in the Treatment of Plantar Fasciitis (PFA)	Phase 2	231		Plantar Fasciitis	COLLAGENASE CLOSTRIDIUM HISTOLYTICUM	Its record names the disease	ClinicalTrials.gov
NCT05339542	Platelet Rich Plasma in Plantar Fasciitis	Not applicable	98		Plantar Fascitis	METHYLPREDNISOLONE	Its record names the disease	ClinicalTrials.gov
NCT05647291	Is ESWT Better in Plantar Fasciitis Treatment?	Not applicable	90		Plantar Fascitis	METHYLPREDNISOLONE	Its record names the disease	ClinicalTrials.gov
NCT04917406	Effect of Iontophoresis vs. Ultrasound and Iontophoresis in Plantar Fasciitis". Plantar Fasciitis"	Not applicable	76		Iontophoresis, Ultrasound Therapy; Complications, Fasciitis, Plantar, Pain, Acute	DEXAMETHASONE, LIDOCAINE	Its record names the disease	ClinicalTrials.gov
NCT05367271	The Efficacy of Botulinum Toxin vs. Corticosteroid for the Treatment of Refractory Plantar Fasciitis	Phase 2/3	62		Plantar Fasciitis	DEXAMETHASONE	Its record names the disease	ClinicalTrials.gov
NCT05984121	Comparison of the Effectiveness of Local Ozone Injection and Dextrose Prolotherapy Injection in Chronic Plantar Fasciitis	Not applicable	60		Plantar Fascitis	DEXTROSE, OZONE	Its record names the disease	ClinicalTrials.gov

1 to 10 of 13

See all 13 trials

Comparisons in its trials4

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
DAXI 240 U vs Placebo: deaths from any cause	0 of 30	0 of 29	59	NCT03137407	Trial comparisons
DAXI 240 U vs Placebo: serious adverse events	1 of 30	0 of 29	59	NCT03137407	Trial comparisons
DAXI 240 U vs Placebo: deaths from any cause	0 of 3	0 of 4	7	NCT02973269	Trial comparisons
DAXI 240 U vs Placebo: serious adverse events	0 of 3	0 of 4	7	NCT02973269	Trial comparisons

Papers from its trials6

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
34214104	RESULT	1	PubMed
30828215	RESULT	1	PubMed
23386757	RESULT	1	PubMed
22421623	RESULT	1	PubMed
15811212	RESULT	1	PubMed
10534247	RESULT	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/EFO_1001909

GET https://conductscience.org/api/diseases/v1/EFO_1001909/drugs?page=2

API reference For AI assistants