Disease · HP_0004763
Paroxysmal supraventricular tachycardia
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. Paroxysmal supraventricular tachycardia. Diseases, record HP_0004763. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/HP_0004763
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
- Name
- Paroxysmal supraventricular tachycardia
- Open Targets ID
- HP_0004763
- Other names
- Episodic supraventricular tachycardia, PSVT
- Highest stage of its drugs
- Approval, for 1 of its 4 drugs, from TTD
Source Open Targets
Drugs4
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| ADENOSINE | CHEMBL477 | Small molecule | Approval | TTD | 2 | 1 | 1 | Drugs and targets |
| ETRIPAMIL | CHEMBL3707312 | Small molecule | Phase 3 | ClinicalTrials.gov | 8 | 7 | 7 | Drugs and targets |
| AZIMILIDE DIHYDROCHLORIDE | CHEMBL3140370 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| VERAPAMIL | CHEMBL6966 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
Targets8
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| ADORA1 | Adenosine receptor | 1 | Adenosine receptor agonist | Approval | https://conductscience.org/library/genes/134 | Drugs and targets |
| ADORA2A | Adenosine receptor | 1 | Adenosine receptor agonist | Approval | https://conductscience.org/library/genes/135 | Drugs and targets |
| ADORA2B | Adenosine receptor | 1 | Adenosine receptor agonist | Approval | https://conductscience.org/library/genes/136 | Drugs and targets |
| ADORA3 | Adenosine receptor | 1 | Adenosine receptor agonist | Approval | https://conductscience.org/library/genes/140 | Drugs and targets |
| CACNA1C | Voltage-gated L-type calcium channel | 1 | Voltage-gated L-type calcium channel blocker | Phase 3 | https://conductscience.org/library/genes/775 | Drugs and targets |
| CACNA1D | Voltage-gated L-type calcium channel | 1 | Voltage-gated L-type calcium channel blocker | Phase 3 | https://conductscience.org/library/genes/776 | Drugs and targets |
| CACNA1F | Voltage-gated L-type calcium channel | 1 | Voltage-gated L-type calcium channel blocker | Phase 3 | https://conductscience.org/library/genes/778 | Drugs and targets |
| CACNA1S | Voltage-gated L-type calcium channel | 1 | Voltage-gated L-type calcium channel blocker | Phase 3 | https://conductscience.org/library/genes/779 | Drugs and targets |
Trials9
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT04072835 | Safety Study of Etripamil Nasal Spray for Patients With Paroxysmal Supraventricular Tachycardia. NODE-303 | Phase 3 | 1,116 | 2024-05-23 | Paroxysmal Supraventricular Tachycardia | ETRIPAMIL | Its record names the disease | ClinicalTrials.gov |
| NCT03464019 | Efficacy and Safety of Etripamil for the Termination of Spontaneous Paroxysmal Supraventricular Tachycardia (PSVT). | Phase 3 | 1,097 | 2024-07-12 | Paroxysmal Supraventricular Tachycardia | ETRIPAMIL | Its record names the disease | ClinicalTrials.gov |
| NCT02296190 | Efficacy and Safety of Intranasal MSP-2017 (Etripamil) for the Conversion of PSVT to Sinus Rhythm | Phase 2 | 199 | 2020-12-30 | Paroxysmal Supraventricular Tachycardia (PSVT) | ETRIPAMIL | Its record names the disease | ClinicalTrials.gov |
| NCT03635996 | Safety Study of Intranasal Etripamil for the Termination of Spontaneous Episodes of Paroxysmal Supraventricular Tachycardia (PSVT). NODE-302 | Phase 3 | 169 | 2023-04-24 | Paroxysmal Supraventricular Tachycardia | ETRIPAMIL | Its record names the disease | ClinicalTrials.gov |
| NCT05410860 | Efficacy and Safety Study of Etripamil Nasal Spray Self-Administration for the Termination of Spontaneous Episodes of Paroxysmal Supraventricular Tachycardia | Phase 3 | 500 | Tachycardia, Supraventricular, Paroxysmal Supraventricular Tachycardia | ETRIPAMIL | Its record names the disease | ClinicalTrials.gov | |
| NCT00035477 | Efficacy and Safety of Azimilide for the Treatment of Patients With Atrial Fibrillation | Phase 3 | 446 | Atrial Fibrillation | AZIMILIDE DIHYDROCHLORIDE | Its record names the disease | ClinicalTrials.gov | |
| NCT06717685 | Efficacy of Adenosine as Compared to Verapamil in Paroxysmal Supraventricular Tachycardia (pSVT) Patients | Phase 3 | 210 | Supraventricular Tachycardia (SVtach) | ADENOSINE, VERAPAMIL | Its record names the disease | ClinicalTrials.gov | |
| NCT04952610 | Etripamil Nasal Spray in Patients With Paroxysmal Supraventricular Tachycardia | Phase 3 | 130 | Paroxysmal Supraventricular Tachycardia | ETRIPAMIL | Its record names the disease | ClinicalTrials.gov | |
| NCT05763953 | The NODE-202 Study (Study of Etripamil Nasal Spray in Pediatric Patients) | Phase 2 | 60 | Paroxysmal Supraventricular Tachycardia | ETRIPAMIL | Its record names the disease | ClinicalTrials.gov |
Comparisons in its trials2
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| Etripamil vs Not Treated: deaths from any cause | 4 of 503 | 7 of 613 | 1,116 | NCT04072835 | Trial comparisons |
| Etripamil vs Not Treated: serious adverse events | 34 of 503 | 22 of 613 | 1,116 | NCT04072835 | Trial comparisons |
Papers from its trials7
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/HP_0004763
GET https://conductscience.org/api/diseases/v1/HP_0004763/drugs