Disease · MONDO_0005276

dental caries

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. dental caries. Diseases, record MONDO_0005276. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0005276

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: dental caries; Open Targets
Open Targets ID: MONDO_0005276; Open Targets
Other names: CARIES DENT, Caries, Dental, DECAY DENT, DENT CARIES, DENT DECAY, DENT WHITE SPOT, DENT WHITE SPOTS, Decay, Dental, Dental Decay, Dental White Spot, Dental White Spots, Spot, White, Spots, White, WHITE SPOT DENT, WHITE SPOTS DENT, White Spot, White Spot, Dental, White Spots, White Spots, Dental, caries; Open Targets
Disease Ontology: DOID:216; Disease Ontology
MeSH: D003731; MeSH
Highest stage of its drugs: Approval, for 3 of its 38 drugs, from DailyMed; Open Targets

Drugs38

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
SODIUM FLUORIDE	CHEMBL1528	Small molecule	Approval	DailyMed	53	24	23	Drugs and targets
SODIUM MONOFLUOROPHOSPHATE	CHEMBL1908359	Small molecule	Approval	DailyMed	22	6	6	Drugs and targets
STANNOUS FLUORIDE	CHEMBL1909079	Small molecule	Approval	DailyMed	12	2	2	Drugs and targets
SILVER DIAMMINE FLUORIDE	CHEMBL4297206	Small molecule	Phase 3	ClinicalTrials.gov	26	26	26	Drugs and targets
CHLORHEXIDINE	CHEMBL790	Small molecule	Phase 3	ClinicalTrials.gov	9	9	9	Drugs and targets
SILVER NITRATE	CHEMBL177367	Small molecule	Phase 3	ClinicalTrials.gov	3	3	3	Drugs and targets
ARGININE	CHEMBL1485	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
POLIGLUSAM	CHEMBL2108133	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
TITANIUM DIOXIDE	CHEMBL1201136	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
FLUORIDE	CHEMBL1232767	Small molecule	Phase 2/3	ClinicalTrials.gov	13	13	12	Drugs and targets

1 to 10 of 38

See all 38 drugs

Targets3

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
HMGCR	3-hydroxy-3-methylglutaryl-coenzyme A reductase	1	HMG-CoA reductase inhibitor	Phase 1	https://conductscience.org/library/genes/3156	Drugs and targets
MTNR1A	Melatonin receptor	1	Melatonin receptor agonist	Unknown	https://conductscience.org/library/genes/4543	Drugs and targets
MTNR1B	Melatonin receptor	1	Melatonin receptor agonist	Unknown	https://conductscience.org/library/genes/4544	Drugs and targets

Trials77

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 2 more are not shown, since the checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT02492841	Calcium Hydroxide, Mineral Trioxide Aggregate and Biodentine (Trademark) as Direct Pulp Capping of Permanent Teeth	Phase 2/3	169	2017-08-14	Caries, Dental Pulp Exposure	CALCIUM HYDROXIDE	Its record names the disease	ClinicalTrials.gov
NCT01657877	Anti-caries Potential of a Sodium Monofluorophosphate and Calcium Sodium Phosphosilicate Dentifrice	Phase 2	100	2014-07-24	Caries	CALCIUM SODIUM PHOSPHOSILICATE, SODIUM MONOFLUOROPHOSPHATE	Its record names the disease	ClinicalTrials.gov
NCT02399163	Evaluation of Oral Hygiene Products in an In Situ Caries Model	Not applicable	80	2016-05-12	Dental Caries	FLUORIDE	Its record names the disease	ClinicalTrials.gov
NCT02536040	Stopping Cavities Study: Diammine Silver Fluoride	Phase 3	66	2020-01-23	Dental Caries	SILVER DIAMMINE FLUORIDE	Its record names the disease	ClinicalTrials.gov
NCT01005966	In Situ Caries Model of Fluoride Toothpastes	Phase 3	65	2013-07-29	Caries	SODIUM FLUORIDE, SODIUM MONOFLUOROPHOSPHATE	Its record names the disease	ClinicalTrials.gov
NCT01563172	Effect of Dentifrice Usage Regime on Delivery and Efficacy of Fluoride	Phase 4	65	2017-08-10	Dental Caries	SODIUM FLUORIDE	Its record names the disease	ClinicalTrials.gov
NCT02195583	The Effect of Experimental Dentifrices on Remineralization of Caries Lesions In-situ	Not applicable	62	2015-04-07	Oral Hygiene	SODIUM FLUORIDE	Its record names the disease	ClinicalTrials.gov
NCT04399161	Anticaries Effect of Xylitol,Probiotic and Chlorhexidine Mouth Rinses Among Individuals at High Risk	Phase 2/3	60	2020-07-22	Cariostatic Agents, Mouthwashes	CHLORHEXIDINE, XYLITOL	Its record names the disease	ClinicalTrials.gov
NCT02751320	Efficacy of Three Toothpastes Using an in Situ Caries Model	Not applicable	58	2017-10-13	Dental Caries	FLUORIDE, PHYTATE, SODIUM CITRATE, ZINC CHLORIDE	Its record names the disease	ClinicalTrials.gov
NCT00708097	In Situ Caries Efficacy of Fluoride Toothpastes	Phase 3	57	2013-06-24	Caries	SODIUM FLUORIDE, SODIUM MONOFLUOROPHOSPHATE	Its record names the disease	ClinicalTrials.gov

1 to 10 of 77

See all 77 trials

Comparisons in its trials4

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
38% Diamine Silver Fluoride vs Water: deaths from any cause	0 of 29	0 of 35	64	NCT02536040	Trial comparisons
38% Diamine Silver Fluoride vs Water: serious adverse events	0 of 29	0 of 35	64	NCT02536040	Trial comparisons
Nano Silver Fluoride Solution vs Cavity Cleanser: deaths from any cause	0 of 22	0 of 22	44	NCT03186261	Trial comparisons
Nano Silver Fluoride Solution vs Cavity Cleanser: serious adverse events	0 of 22	0 of 22	44	NCT03186261	Trial comparisons

Papers from its trials36

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
33440268	RESULT	1	PubMed
32522320	RESULT	2	PubMed
32041360	RESULT	1	PubMed
31963463	RESULT	1	PubMed
31299955	RESULT	1	PubMed
31158253	RESULT	1	PubMed
30809328	RESULT	1	PubMed
30447792	RESULT	1	PubMed
28862586	RESULT	1	PubMed
28692829	RESULT	1	PubMed

1 to 10 of 36

See all 36 papers from its trials

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0005276

GET https://conductscience.org/api/diseases/v1/MONDO_0005276/drugs?page=2

API reference For AI assistants