Disease · MONDO_0017990

catecholaminergic polymorphic ventricular tachycardia

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. catecholaminergic polymorphic ventricular tachycardia. Diseases, record MONDO_0017990. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0017990

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: catecholaminergic polymorphic ventricular tachycardia; Open Targets
Open Targets ID: MONDO_0017990; Open Targets
Other names: CPVT, bidirectional tachycardia induced by catecholamine, double tachycardia induced by catecholamines, malignant paroxysmal ventricular tachycardia, multifocal ventricular premature beats, ventricular tachycardia, catecholaminergic polymorphic; Open Targets
Disease Ontology: DOID:0060674; Disease Ontology
MeSH: C536334; MeSH
Orphanet: ORPHA:3286; Orphanet
Highest stage of its drugs: Unknown, for 6 of its 6 drugs, from ClinicalTrials.gov; Open Targets

Drugs6

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
ATENOLOL	CHEMBL24	Small molecule	Unknown	ClinicalTrials.gov	1	1	0	Drugs and targets
ATROPINE	CHEMBL517712	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
BEPOTASTINE BESYLATE	CHEMBL1201759	Small molecule	Unknown	ClinicalTrials.gov	1	1	0	Drugs and targets
FLECAINIDE	CHEMBL652	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
METOPROLOL	CHEMBL13	Small molecule	Unknown	ClinicalTrials.gov	1	1	0	Drugs and targets
PROPRANOLOL	CHEMBL27	Small molecule	Unknown	ClinicalTrials.gov	1	1	0	Drugs and targets

Targets7

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
ADRB1	Beta-1 adrenergic receptor	3	Beta-1 adrenergic receptor antagonist	Unknown	https://conductscience.org/library/genes/153	Drugs and targets
ADRB2	Beta-2 adrenergic receptor	1	Beta-2 adrenergic receptor antagonist	Unknown	https://conductscience.org/library/genes/154	Drugs and targets
CHRM1	Muscarinic acetylcholine receptor M1	1	Muscarinic acetylcholine receptor M1 antagonist	Unknown	https://conductscience.org/library/genes/1128	Drugs and targets
CHRM2	Muscarinic acetylcholine receptor M2	1	Muscarinic acetylcholine receptor M2 antagonist	Unknown	https://conductscience.org/library/genes/1129	Drugs and targets
CHRM3	Muscarinic acetylcholine receptor M3	1	Muscarinic acetylcholine receptor M3 antagonist	Unknown	https://conductscience.org/library/genes/1131	Drugs and targets
HRH1	Histamine H1 receptor	1	Histamine H1 receptor antagonist	Unknown	https://conductscience.org/library/genes/3269	Drugs and targets
SCN5A	Sodium channel protein type 5 subunit alpha	1	Sodium channel protein type V alpha subunit blocker	Unknown	https://conductscience.org/library/genes/6331	Drugs and targets

Trials2

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT01117454	Flecainide for Catecholaminergic Polymorphic Ventricular Tachycardia	Not applicable	14	2017-05-17	Catecholaminergic Polymorphic Ventricular Tachycardia	FLECAINIDE	Its record names the disease	ClinicalTrials.gov
NCT02927223	Atropine in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)	Not applicable	6	2020-01-28	Catecholaminergic Polymorphic Ventricular Tachycardia	ATROPINE	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials5

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Flecainide vs Placebo: deaths from any cause	0 of 13	0 of 13	26	NCT01117454	Trial comparisons
Flecainide vs Placebo: serious adverse events	2 of 13	2 of 13	26	NCT01117454	Trial comparisons
Flecainide vs Placebo: Number of Patients With Ventricular Ectopy or VT During Exercise Treadmill Testing	2 of 12	9 of 12	24	NCT01117454	Trial comparisons
Treadmill vs Treadmill With Atropine: deaths from any cause	0 of 6	0 of 6	12	NCT02927223	Trial comparisons
Treadmill vs Treadmill With Atropine: serious adverse events	0 of 6	0 of 6	12	NCT02927223	Trial comparisons

Papers from its trials1

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it
32091590	DERIVED	1

Source PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0017990

GET https://conductscience.org/api/diseases/v1/MONDO_0017990/drugs

API reference For AI assistants