Disease · MONDO_0021108

meningitis

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. meningitis. Diseases, record MONDO_0021108. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0021108

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: meningitis; Open Targets
Open Targets ID: MONDO_0021108; Open Targets
Other names: Unusual infectious meningitis, Unusual meningitis, inflammation of meninx, meningitis (disease), meninx inflammation; Open Targets
MeSH: D008581; MeSH
NCI Thesaurus: C26828; NCI Thesaurus
Highest stage of its drugs: Approval, for 2 of its 20 drugs, from PMDA and TTD; Open Targets

Drugs20

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
ITRACONAZOLE	CHEMBL64391	Small molecule	Approval	PMDA	1	0	0	Drugs and targets
NEISSERIA MENINGITIDIS FACTOR H BINDING PROTEIN	CHEMBL6068499	Vaccine component	Approval	TTD	1	0	0	Drugs and targets
RIFAMPIN	CHEMBL374478	Small molecule	Phase 3	ClinicalTrials.gov	4	4	4	Drugs and targets
ASPIRIN	CHEMBL25	Small molecule	Phase 3	ClinicalTrials.gov	3	3	3	Drugs and targets
DEXAMETHASONE	CHEMBL384467	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
ISONIAZID	CHEMBL64	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
LINEZOLID	CHEMBL126	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
PYRAZINAMIDE	CHEMBL614	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
MOXIFLOXACIN	CHEMBL32	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
AVIBACTAM	CHEMBL1689063	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets

1 to 10 of 20

See all 20 drugs

Targets6

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
PTGS1	Cyclooxygenase	2	Cyclooxygenase inhibitor	Phase 3	https://conductscience.org/library/genes/5742	Drugs and targets
PTGS2	Cyclooxygenase	2	Cyclooxygenase inhibitor	Phase 3	https://conductscience.org/library/genes/5743	Drugs and targets
FGA	Fibrinogen	1	Fibrinogen exogenous protein	Unknown	https://conductscience.org/library/genes/2243	Drugs and targets
FGB	Fibrinogen	1	Fibrinogen exogenous protein	Unknown	https://conductscience.org/library/genes/2244	Drugs and targets
FGG	Fibrinogen	1	Fibrinogen exogenous protein	Unknown	https://conductscience.org/library/genes/2266	Drugs and targets
NR3C1	Glucocorticoid receptor	1	Glucocorticoid receptor agonist	Phase 3	https://conductscience.org/library/genes/2908	Drugs and targets

Trials13

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT03309657	Pharmacokinetics of Ceftolozane/Tazobactam in Plasma and Cerebrospinal Fluid	Phase 1/2	10	2020-09-10	Pharmacokinetics	CEFTOLOZANE, TAZOBACTAM	Its record names the disease	ClinicalTrials.gov
NCT04145258	Intensified Tuberculosis Treatment to Reduce the Mortality of Patients With Tuberculous Meningitis	Phase 3	768		Tuberculous Meningitis	ASPIRIN, LINEZOLID, RIFAMPIN	Open Targets' reading, confirmed by NLM's indexing of its papers	ClinicalTrials.gov
NCT03100786	Leukotriene A4 Hydrolase Stratified Trial of Adjunctive Corticosteroids for HIV-uninfected Adults With Tuberculous Meningitis	Phase 3	702		Tuberculosis, Tuberculous Meningitis, Drug-Induced Liver Injury	DEXAMETHASONE	Open Targets' reading, confirmed by NLM's indexing of its papers	ClinicalTrials.gov
NCT03092817	Adjunctive Corticosteroids for Tuberculous Meningitis in HIV-infected Adults (The ACT HIV Trial)	Phase 3	520		Tuberculosis, Tuberculous Meningitis, Drug-Induced Liver Injury, HIV, IRIS	DEXAMETHASONE	Open Targets' reading, confirmed by NLM's indexing of its papers	ClinicalTrials.gov
NCT05917340	Intensified Short Course Regimen for TBM in Adults	Phase 3	372		Tuberculous Meningitis	ASPIRIN, ISONIAZID, MOXIFLOXACIN, PYRAZINAMIDE, RIFAMPIN	Open Targets' reading, confirmed by NLM's indexing of its papers	ClinicalTrials.gov
NCT05383742	Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents With Tuberculous Meningitis	Phase 2	330		Tuberculous Meningitis	ISONIAZID, LINEZOLID, PYRAZINAMIDE, RIFAMPIN	Open Targets' reading of its record	ClinicalTrials.gov
NCT02853292	Incidence, Risk Factors and Impact on Renal Function of the Appearance of Crystalluria Under High-dose Intravenous Amoxicillin		153		Amoxicillin Crystalluria	AMOXICILLIN	Its record names the disease	ClinicalTrials.gov
NCT02237365	A Pilot Study of Adjunctive Aspirin for the Treatment of HIV Negative Adults With Tuberculous Meningitis	Phase 2	120		Tuberculous Meningitis	ASPIRIN	Open Targets' reading, confirmed by NLM's indexing of its papers	ClinicalTrials.gov
NCT07431307	Safety, Pharmacokinetics and Efficacy of BV100 Plus Low Dose Polymyxin B Plus Ceftazidime/Avibactam, or Plus Cefiderocol in Patients With Pulmonary and Extrapulmonary Infections Due to Carbapenem-resistant Acinetobacter Baumannii-calcoaceticus Complex	Phase 2	120		Ventilator Associated Bacterial Pneumonia (VABP), Hospital Acquired Bacterial Pneumonia (HABP), Blood Stream Infection, Meningitis, Bacterial, Ventriculitis, Infectious	AVIBACTAM, CEFIDEROCOL, CEFTAZIDIME, POLYMYXIN B	Its record names the disease	ClinicalTrials.gov
NCT06068673	The Potential Impact of Clindamycin on Neurosurgery Patients.	Not applicable	44		Neurologic Complication, Neurosurgery	CLINDAMYCIN	Its record names the disease	ClinicalTrials.gov

1 to 10 of 13

See all 13 trials

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials22

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
36348453	RESULT	1	PubMed
35767219	RESULT	1	PubMed
34916315	RESULT	1	PubMed
34499261	RESULT	1	PubMed
33538867	RESULT	1	PubMed
31058968	RESULT	1	PubMed
29232819	RESULT	1	PubMed
28751035	RESULT	1	PubMed
28729143	RESULT	1	PubMed
28529027	RESULT	1	PubMed

1 to 10 of 22

See all 22 papers from its trials

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0021108

GET https://conductscience.org/api/diseases/v1/MONDO_0021108/papers?page=2

API reference For AI assistants