Disease · MONDO_0024503

digestive system neuroendocrine neoplasm

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. digestive system neuroendocrine neoplasm. Diseases, record MONDO_0024503. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0024503

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: digestive system neuroendocrine neoplasm; Open Targets
Open Targets ID: MONDO_0024503; Open Targets
Other names: alimentary part of gastrointestinal system NET, alimentary part of gastrointestinal system neuroendocrine neoplasm, alimentary part of gastrointestinal system neuroendocrine tumor, alimentary part of gastrointestinal system neuroendocrine tumor, well differentiated, low or intermediate grade, alimentary part of gastrointestinal system neuroendocrine tumour, carcinoid tumor of digestive system, carcinoid tumour of digestive system, digestive system NET, digestive system neuroendocrine tumor, digestive system neuroendocrine tumor, well differentiated, low or intermediate grade, digestive system neuroendocrine tumour, gastro-enteropancreatic neuroendocrine tumor, gastro-enteropancreatic neuroendocrine tumour, gastroenteropancreatic endocrine tumor, gastroenteropancreatic endocrine tumour, gastroenteropancreatic neuroendocrine neoplasm, gastrointestinal neuroendocrine neoplasm, gastrointestinal system neuroendocrine neoplasm, neuroendocrine neoplasm of alimentary part of gastrointestinal system, neuroendocrine neoplasm of digestive system; Open Targets
MeSH: C535650; MeSH
NCI Thesaurus: C27721; NCI Thesaurus
Orphanet: ORPHA:100092; Orphanet
Highest stage of its drugs: Phase 2, for 2 of its 5 drugs, from ClinicalTrials.gov; Open Targets

Drugs5

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
FAMITINIB	CHEMBL1278146	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
SUNITINIB	CHEMBL535	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
LANREOTIDE	CHEMBL1201185	Protein	Phase 1/2	ClinicalTrials.gov	1	1	1	Drugs and targets
PEMBROLIZUMAB	CHEMBL3137343	Antibody	Phase 1/2	ClinicalTrials.gov	1	1	1	Drugs and targets
LUTETIUM OXODOTREOTIDE LU-177	CHEMBL4297545	Protein	Phase 1	ClinicalTrials.gov	1	1	0	Drugs and targets

Targets15

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
FLT1	Vascular endothelial growth factor receptor	2	Vascular endothelial growth factor receptor 1 inhibitor; Vascular endothelial growth factor receptor inhibitor	Phase 2	https://conductscience.org/library/genes/2321	Drugs and targets
FLT3	Receptor-type tyrosine-protein kinase FLT3	2	Tyrosine-protein kinase receptor FLT3 inhibitor	Phase 2	https://conductscience.org/library/genes/2322	Drugs and targets
FLT4	Vascular endothelial growth factor receptor	2	Vascular endothelial growth factor receptor 3 inhibitor; Vascular endothelial growth factor receptor inhibitor	Phase 2	https://conductscience.org/library/genes/2324	Drugs and targets
KDR	Vascular endothelial growth factor receptor	2	Vascular endothelial growth factor receptor 2 inhibitor; Vascular endothelial growth factor receptor inhibitor	Phase 2	https://conductscience.org/library/genes/3791	Drugs and targets
KIT	Mast/stem cell growth factor receptor Kit	2	Stem cell growth factor receptor inhibitor	Phase 2	https://conductscience.org/library/genes/3815	Drugs and targets
PDGFRA	Platelet-derived growth factor receptor	2	Platelet-derived growth factor receptor alpha inhibitor; Platelet-derived growth factor receptor inhibitor	Phase 2	https://conductscience.org/library/genes/5156	Drugs and targets
PDGFRB	Platelet-derived growth factor receptor	2	Platelet-derived growth factor receptor beta inhibitor; Platelet-derived growth factor receptor inhibitor	Phase 2	https://conductscience.org/library/genes/5159	Drugs and targets
SSTR2	Somatostatin receptor	2	Somatostatin receptor 2 agonist; Somatostatin receptor binding agent	Phase 1/2	https://conductscience.org/library/genes/6752	Drugs and targets
SSTR5	Somatostatin receptor	2	Somatostatin receptor 5 agonist; Somatostatin receptor binding agent	Phase 1/2	https://conductscience.org/library/genes/6755	Drugs and targets
CSF1R	Macrophage colony-stimulating factor 1 receptor	1	Macrophage colony stimulating factor receptor inhibitor	Phase 2	https://conductscience.org/library/genes/1436	Drugs and targets

1 to 10 of 15

See all 15 targets

Trials3

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 1 more is not shown, since the checks do not confirm it.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT03043664	Study of Pembrolizumab With Lanreotide Depot for Gastroenteropancreatic Neuroendocrine Tumors	Phase 1/2	22	2022-09-28	Gastroenteropancreatic Neuroendocrine Tumors	LANREOTIDE, PEMBROLIZUMAB	Open Targets' reading of its record	ClinicalTrials.gov
NCT00056693	Treatment With SU11248 in Patients With Neuroendocrine Tumors	Phase 2	107		Neuroendocrine Tumors	SUNITINIB	Open Targets' reading of its record	ClinicalTrials.gov
NCT01994213	A Study of Famitinib in Patients With Advanced or Metastatic Gastroenteropancreatic Neuroendocrine Tumor	Phase 2	53		Gastroenteropancreatic Neuroendocrine Tumor	FAMITINIB	Open Targets' reading of its record	ClinicalTrials.gov

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials2

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
29161241	DERIVED	1	PubMed
25756398	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0024503

GET https://conductscience.org/api/diseases/v1/MONDO_0024503/drugs

API reference For AI assistants