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Paper · 28481359

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.

Zehir A and 99 others. Nat Med, 2017. Cited by 2,760 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients. Papers, record 28481359. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/28481359

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
PubMed
Journal
Nat Med
PubMed
Year
2017
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
2,760
iCite
Relative citation ratio, by iCite
86.2
iCite
Revised in PubMed
2025-09-26
PubMed

Authors100

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Zehir AAhmethttps://orcid.org/0000-0001-5406-4104
2Benayed RRyma
3Shah RHRonak H
4Syed AAijazuddin
5Middha SSumithttps://orcid.org/0000-0003-4135-6268
6Kim HRHyunjae Rhttps://orcid.org/0000-0002-1869-0412
7Srinivasan PPreethi
8Gao JJianjiong
9Chakravarty DDebyani
10Devlin SMSean M

1 to 10 of 100Source PubMed

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Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Biomarkers, TumorMajor topic
DNA, NeoplasmMajor topic
Neoplasm MetastasisMajor topic
NeoplasmsMajor topic
Cohort Studies
Data Mining
Feasibility Studies
Female
Genomics
High-Throughput Nucleotide Sequencing
Humans
Male
Mutation
Prospective Studies
Sequence Analysis, DNA

Source PubMed

Grants7

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
K08 DE024774NIDCR NIH HHSUnited StatesK08DE024774PubMed and NIHNIH RePORTER
P50 CA092629NCI NIH HHSUnited StatesP50CA092629PubMed and NIHNIH RePORTER
P30 CA008748NCI NIH HHSUnited StatesP30CA008748PubMed and NIHNIH RePORTER
R01 CA182587NCI NIH HHSUnited StatesR01CA182587PubMed and NIHNIH RePORTER
R01 CA204749NCI NIH HHSUnited StatesR01CA204749PubMed and NIHNIH RePORTER
P01 CA129243NCI NIH HHSUnited StatesP01CA129243PubMed and NIHNIH RePORTER
T32CA009207NIHNIH RePORTER

Trials4

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

TrialTitleThe trial lists it asNamed in the paper's recordSource
NCT03824691hARnessing CAbozantinib and Durvalumab Immuno-oncology Association: ARCADIA Study"ResultsClinicalTrials.gov
NCT04489706Arsenic Trioxide in Recurrent and Metastatic Ovarian Cancer and Endometrial Cancer With P53 MutationResultsClinicalTrials.gov
NCT05179824Tempus Priority Study: A Pan-tumor Observational StudyBackgroundClinicalTrials.gov
NCT05719428Neural Network-based Treatment Decision Support Tool in Patients With Refractory Solid Organ MalignanciesBackgroundClinicalTrials.gov

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Erratum in28,777,785Erratum: Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.https://conductscience.org/library/papers/28777785

Source PubMed

References61

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
112,471,243The protein kinase complement of the human genome.Science2002https://conductscience.org/library/papers/12471243PubMed
214,681,465The UCSC Table Browser data retrieval tool.Nucleic Acids Res2004https://conductscience.org/library/papers/14681465PubMed
319,451,168Fast and accurate short read alignment with Burrows-Wheeler transform.Bioinformatics2009https://conductscience.org/library/papers/19451168PubMed
419,561,018Pindel: a pattern growth approach to detect break points of large deletions and medium sized insertions from paired-end short reads.Bioinformatics2009https://conductscience.org/library/papers/19561018PubMed
520,644,199The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data.Genome Res2010https://conductscience.org/library/papers/20644199PubMed
621,639,808Improved survival with vemurafenib in melanoma with BRAF V600E mutation.N Engl J Med2011https://conductscience.org/library/papers/21639808PubMed
722,113,612RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E).Nature2011https://conductscience.org/library/papers/22113612PubMed
822,133,722Personalized oncology through integrative high-throughput sequencing: a pilot study.Sci Transl Med2011https://conductscience.org/library/papers/22133722PubMed
922,517,427Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration.Brief Bioinform2013https://conductscience.org/library/papers/22517427PubMed
1022,588,877The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data.Cancer Discov2012https://conductscience.org/library/papers/22588877PubMed

1 to 10 of 61

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Cited by2,167

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 2,760 citations.

PMIDTitleJournalYearIn PapersSource
42,979,327Concurrent loss of RB1 facilitates EGFR-TKI resistance in EGFR-mutant lung cancer by modulating histone crotonylation.Acta Pharm Sin B2026https://conductscience.org/library/papers/42979327PubMed
42,957,651Targeted degradation of P-TEFb via MDM2 substrate substitution collapses oncogenic transcriptional programs in MDM2-amplified cancers.Cell Death Dis2026https://conductscience.org/library/papers/42957651PubMed
42,938,302Decentralizing Clinical Tumor Exome Analysis: On-Premises GPU-Based Secondary Analysis in a Clinical Molecular Laboratory.Genes (Basel)2026https://conductscience.org/library/papers/42938302PubMed
42,902,326Cancer metastasis: biological mechanisms, therapeutic bottlenecks, and emerging interventions.J Hematol Oncol2026https://conductscience.org/library/papers/42902326PubMed
42,889,575RTK-RAS pathway alterations in hepatocellular carcinoma and cholangiocarcinoma: a multicohort genomic and single-cell transcriptomic study.Front Oncol2026https://conductscience.org/library/papers/42889575PubMed
42,875,424Antagonistic roles of histone H3 lysine methyltransferases dictate tumor immune surveillance.Nat Commun2026https://conductscience.org/library/papers/42875424PubMed
42,852,590Co-mutation patterns and survival associations in lung cancer: a comparative analysis of Swedish and global cohorts.Acta Oncol2026https://conductscience.org/library/papers/42852590PubMed
42,845,513'An NF2-wildtype malignant meningioma cell line for basic and translational science'.bioRxiv2026https://conductscience.org/library/papers/42845513PubMed
42,839,920Real world genomic profiling in non-small cell lung cancer reveals regional variations with clinical implications.Front Oncol2026https://conductscience.org/library/papers/42839920PubMed
42,791,474Integrated Structural and Dynamic Analysis Reveals Destabilizing Effects of KRAS Missense Variants Associated with Lung Cancer.Protein J2026https://conductscience.org/library/papers/42791474PubMed

1 to 10 of 2,167

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Genes29

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ALK238PubTator's text mininghttps://conductscience.org/library/genes/238NCBI Gene
APC324PubTator's text mininghttps://conductscience.org/library/genes/324NCBI Gene
AR367PubTator's text mininghttps://conductscience.org/library/genes/367NCBI Gene
BRAF673PubTator's text mininghttps://conductscience.org/library/genes/673NCBI Gene
CD27429,126PubTator's text mininghttps://conductscience.org/library/genes/29126NCBI Gene
CDK5RAP255,755PubTator's text mininghttps://conductscience.org/library/genes/55755NCBI Gene
DNAJB13,337PubTator's text mininghttps://conductscience.org/library/genes/3337NCBI Gene
EGFR1,956PubTator's text mininghttps://conductscience.org/library/genes/1956NCBI Gene
EML427,436PubTator's text mininghttps://conductscience.org/library/genes/27436NCBI Gene
ERG2,078PubTator's text mininghttps://conductscience.org/library/genes/2078NCBI Gene

1 to 10 of 29

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Drugs3

The drugs whose trials, in the Pipelines release, list the paper.

DrugChEMBL IDThe trials list it asTrialsIn Drugs and targetsSource
CABOZANTINIBCHEMBL2105717Results1https://conductscience.org/library/drugs/CHEMBL2105717ChEMBL
DURVALUMABCHEMBL3301587Results1https://conductscience.org/library/drugs/CHEMBL3301587ChEMBL
ARSENIC TRIOXIDECHEMBL5483015Results1https://conductscience.org/library/drugs/CHEMBL5483015ChEMBL

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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