Paper · 35842425

Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity.

Zhang Z and 10 others. Nat Commun, 2022. Cited by 16 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity. Papers, record 35842425. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/35842425

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity.; PubMed
Journal: Nat Commun; PubMed
Year: 2022; PubMed
Publication types: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/35842425/; PubMed
DOI: https://doi.org/10.1038/s41467-022-31812-4; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC9288484/; PubMed
The journal: https://conductscience.org/library/journal-index/101528555; PubMed
Citations, by iCite: 16; iCite
Relative citation ratio, by iCite: 1.39; iCite
Revised in PubMed: 2026-08-22; PubMed

Authors11

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	ORCID iD
1	Zhang Z	Zhao	https://orcid.org/0000-0001-9345-3663
2	Xun Y	Yu
3	Rong S	Shunxing
4	Yan L	Lijuan
5	SoRelle JA	Jeffrey A	https://orcid.org/0000-0003-2588-6277
6	Li X	Xiaohong
7	Tang M	Miao
8	Keller K	Katie
9	Ludwig S	Sara
10	Moresco EMY	Eva Marie Y	https://orcid.org/0000-0002-2049-7291

1 to 10 of 11Source PubMed

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Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Non-alcoholic Fatty Liver Disease	Major topic
Animals
Diet, High-Fat
GTP Phosphohydrolases
Hepatocytes
Lipid Metabolism
Lipids
Liver
Mice
Mice, Inbred C57BL
Obesity

Source PubMed

Grants5

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
P30 DK127984	NIDDK NIH HHS	United States	P30DK127984	PubMed	NIH RePORTER
U19 AI100627	NIAID NIH HHS	United States	U19AI100627	PubMed and NIH	NIH RePORTER
R01 AI125581	NIAID NIH HHS	United States	R01AI125581	PubMed and NIH	NIH RePORTER
R00 DK115766	NIDDK NIH HHS	United States	R00DK115766	PubMed and NIH	NIH RePORTER
R01 DK130959	NIDDK NIH HHS	United States	R01DK130959	PubMed and NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References46

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	21,276,251	The activation mechanism of Irga6, an interferon-inducible GTPase contributing to mouse resistance against Toxoplasma gondii.	BMC Biol	2011	https://conductscience.org/library/papers/21276251	PubMed
2	27,417,217	Variants in the autophagy-related gene IRGM confer susceptibility to non-alcoholic fatty liver disease by modulating lipophagy.	J Hepatol	2016	https://conductscience.org/library/papers/27417217	PubMed
3	26,707,365	Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes.	Hepatology	2016	https://conductscience.org/library/papers/26707365	PubMed
4	25,920,090	NAFLD: a multisystem disease.	J Hepatol	2015	https://conductscience.org/library/papers/25920090	PubMed
5	20,204,628	Isolation and culture of adult mouse hepatocytes.	Methods Mol Biol	2010	https://conductscience.org/library/papers/20204628	PubMed
6	18,359,291	17beta-Hydroxysteroid dehydrogenase type 13 is a liver-specific lipid droplet-associated protein.	Biochem Biophys Res Commun	2008	https://conductscience.org/library/papers/18359291	PubMed
7	18,370,145	ENU mutagenesis in mice.	Methods Mol Biol	2008	https://conductscience.org/library/papers/18370145	PubMed
8	25,854,913	Hepatic lipid droplet biology: Getting to the root of fatty liver.	Hepatology	2015	https://conductscience.org/library/papers/25854913	PubMed
9	30,403,941	HSD17B13 and Chronic Liver Disease in Blacks and Hispanics.	N Engl J Med	2018	https://conductscience.org/library/papers/30403941	PubMed
10	20,737,271	Human IRGM gene "to be or not to be".	Semin Immunopathol	2010	https://conductscience.org/library/papers/20737271	PubMed

1 to 10 of 46

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Cited by11

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 16 citations.

PMID	Title	Journal	Year	In Papers	Source
42,948,748	Emerging insights into PPARα's role in lean metabolic dysfunction-associated steatotic liver disease: Implications for targeted therapies.	Acta Pharm Sin B	2026	https://conductscience.org/library/papers/42948748	PubMed
41,387,427	Structural insights into GM4951 as a lipid droplet GTPase regulating hepatic lipid metabolism.	Nat Commun	2025	https://conductscience.org/library/papers/41387427	PubMed
41,216,177	Preventing effect of plant extracts and omega-3 on age-related cognitive decline in male mice.	Brain Behav Immun Health	2025	https://conductscience.org/library/papers/41216177	PubMed
40,693,465	A hypomorphic Mpi mutation unlocks an in vivo tool for studying global N-glycosylation deficiency.	JCI Insight	2025	https://conductscience.org/library/papers/40693465	PubMed
39,562,829	KBTBD2 controls bone development by regulating IGF-1 signaling during osteoblast differentiation.	Cell Death Differ	2025	https://conductscience.org/library/papers/39562829	PubMed
39,364,045	Transcriptomics-based anti-tuberculous mechanism of traditional Chinese polyherbal preparation NiuBeiXiaoHe intermediates.	Front Pharmacol	2024	https://conductscience.org/library/papers/39364045	PubMed
39,195,801	Transcriptomic Signatures of the Foetal Liver and Late Prenatal Development in Vitrified Rabbit Embryos.	Vet Sci	2024	https://conductscience.org/library/papers/39195801	PubMed
38,504,356	Exploring the role of genetic variations in NAFLD: implications for disease pathogenesis and precision medicine approaches.	Eur J Med Res	2024	https://conductscience.org/library/papers/38504356	PubMed
38,266,508	Triglycerides Mediate the Influence of Body Mass Index on Non-Alcoholic Fatty Liver Disease in a Non-Obese Chinese Population with Normal Low-Density Lipoprotein Cholesterol Levels.	Obes Facts	2024	https://conductscience.org/library/papers/38266508	PubMed
36,973,654	Correlation between nonalcoholic fatty liver disease and left ventricular diastolic dysfunction in non-obese adults: a cross-sectional study.	BMC Gastroenterol	2023	https://conductscience.org/library/papers/36973654	PubMed

1 to 10 of 11

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Genes16

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
ACACA	31	PubTator's text mining	https://conductscience.org/library/genes/31	NCBI Gene
ACOT1	641,371	PubTator's text mining	https://conductscience.org/library/genes/641371	NCBI Gene
ACOX1	51	PubTator's text mining	https://conductscience.org/library/genes/51	NCBI Gene
ACTA1	58	PubTator's text mining	https://conductscience.org/library/genes/58	NCBI Gene
AIFM1	9,131	PubTator's text mining	https://conductscience.org/library/genes/9131	NCBI Gene
APOB	338	PubTator's text mining	https://conductscience.org/library/genes/338	NCBI Gene
DGAT1	8,694	PubTator's text mining	https://conductscience.org/library/genes/8694	NCBI Gene
HSD17B13	345,275	PubTator's text mining	https://conductscience.org/library/genes/345275	NCBI Gene
INS	3,630	PubTator's text mining	https://conductscience.org/library/genes/3630	NCBI Gene
IRGC	56,269	PubTator's text mining	https://conductscience.org/library/genes/56269	NCBI Gene

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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