Disease · MONDO_0000153
transposition of the great arteries
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. transposition of the great arteries. Diseases, record MONDO_0000153. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0000153
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
- Other names
- TGA, TGV, complete transposition, great vessels transposition, transposition of great vessels, transposition of the great vessels
- Open Targets
Drugs3
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| NITRIC OXIDE | CHEMBL1200689 | Small molecule | Phase 3 | ClinicalTrials.gov | 2 | 2 | 2 | Drugs and targets |
| LEVOSIMENDAN | CHEMBL2051955 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| AUTOLOGOUS CORD BLOOD | CHEMBL4594461 | Phase 1/2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
Targets8
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| GUCY1A1 | Soluble guanylate cyclase | 1 | Soluble guanylate cyclase activator | Phase 3 | https://conductscience.org/library/genes/2982 | Drugs and targets |
| GUCY1A2 | Soluble guanylate cyclase | 1 | Soluble guanylate cyclase activator | Phase 3 | https://conductscience.org/library/genes/2977 | Drugs and targets |
| GUCY1B1 | Soluble guanylate cyclase | 1 | Soluble guanylate cyclase activator | Phase 3 | https://conductscience.org/library/genes/2983 | Drugs and targets |
| PDE3A | Phosphodiesterase 3 | 1 | Phosphodiesterase 3 inhibitor | Phase 2 | https://conductscience.org/library/genes/5139 | Drugs and targets |
| PDE3B | Phosphodiesterase 3 | 1 | Phosphodiesterase 3 inhibitor | Phase 2 | https://conductscience.org/library/genes/5140 | Drugs and targets |
| TNNC1 | Troponin, cardiac muscle | 1 | Troponin, cardiac muscle positive modulator | Phase 2 | https://conductscience.org/library/genes/7134 | Drugs and targets |
| TNNI3 | Troponin, cardiac muscle | 1 | Troponin, cardiac muscle positive modulator | Phase 2 | https://conductscience.org/library/genes/7137 | Drugs and targets |
| TNNT2 | Troponin, cardiac muscle | 1 | Troponin, cardiac muscle positive modulator | Phase 2 | https://conductscience.org/library/genes/7139 | Drugs and targets |
Trials4
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT00585013 | Inhaled NO as an Anti-inflammatory and Anti-reperfusion Agent in Infants and Children Undergoing Cardiopulmonary Bypass | Phase 1/2 | 17 | 2015-11-04 | Congenital Heart Disease | NITRIC OXIDE | Open Targets' reading of its record | ClinicalTrials.gov |
| NCT03661385 | Nitric Oxide During Bypass for Arterial Switch Operation | Phase 3 | 300 | Low Cardiac Output Syndrome, Transposition of Great Vessels | NITRIC OXIDE | Its record names the disease | ClinicalTrials.gov | |
| NCT01120106 | Levosimendan Administration in Neonates With Transposition of the Great Arteries | Phase 2 | 63 | Low Cardiac Output Syndrome | LEVOSIMENDAN | Its record names the disease | ClinicalTrials.gov | |
| NCT03558269 | Autologous Umbilical Cord Blood Treatment of Neonate With CHD | Phase 1/2 | 60 | Congenital Heart Disease, Brain Injuries, Low Cardiac Output Syndrome, Neonatal Disorder | AUTOLOGOUS CORD BLOOD | Open Targets' reading of its record | ClinicalTrials.gov |
Comparisons in its trials1
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial |
|---|---|---|---|---|
| 1 Treatment vs 2 Placebo: serious adverse events | 0 of 8 | 0 of 8 | 16 | NCT00585013 |
Source Trial comparisons
Papers from its trials3
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/MONDO_0000153
GET https://conductscience.org/api/diseases/v1/MONDO_0000153/drugs