Disease · MONDO_0001343

impaired renal function disease

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. impaired renal function disease. Diseases, record MONDO_0001343. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0001343

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: impaired renal function disease; Open Targets
Open Targets ID: MONDO_0001343; Open Targets
Other names: renal dysfunction; Open Targets
Disease Ontology: DOID:11705; Disease Ontology
Highest stage of its drugs: Phase 3, for 13 of its 40 drugs, from ClinicalTrials.gov; Open Targets

Drugs40

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
TACROLIMUS	CHEMBL3989887	Small molecule	Phase 3	ClinicalTrials.gov	4	4	4	Drugs and targets
ALISKIREN	CHEMBL1639	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
BENAZEPRIL	CHEMBL838	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
MYCOPHENOLATE MOFETIL	CHEMBL1456	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
NESIRITIDE	CHEMBL1201668	Protein	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
PREDNISONE	CHEMBL635	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
AMLODIPINE	CHEMBL1491	Small molecule	Phase 3	ClinicalTrials.gov	1	1	0	Drugs and targets
ANTILYMPHOCYTE IMMUNOGLOBULIN (HORSE)	CHEMBL2108981		Phase 3	ClinicalTrials.gov	1	1	0	Drugs and targets
BASILIXIMAB	CHEMBL1201439	Antibody	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
GANCICLOVIR	CHEMBL182	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets

1 to 10 of 40

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Targets59

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
ADRB1	Adrenergic receptor beta	2	Adrenergic receptor beta antagonist; Beta-1 adrenergic receptor agonist	Unknown	https://conductscience.org/library/genes/153	Drugs and targets
AVPR2	Vasopressin V2 receptor	2	Vasopressin V2 receptor antagonist; Vasopressin V2 receptor binding agent	Unknown	https://conductscience.org/library/genes/554	Drugs and targets
FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	2	FK506-binding protein 1A inhibitor	Phase 3	https://conductscience.org/library/genes/2280	Drugs and targets
NR3C1	Glucocorticoid receptor	2	Glucocorticoid receptor agonist	Phase 3	https://conductscience.org/library/genes/2908	Drugs and targets
PDE5A	cGMP-specific 3',5'-cyclic phosphodiesterase	2	Phosphodiesterase 5A inhibitor	Phase 1/2	https://conductscience.org/library/genes/8654	Drugs and targets
SSTR1	Somatostatin receptor	2	Somatostatin receptor agonist	Unknown	https://conductscience.org/library/genes/6751	Drugs and targets
SSTR2	Somatostatin receptor	2	Somatostatin receptor agonist	Unknown	https://conductscience.org/library/genes/6752	Drugs and targets
SSTR3	Somatostatin receptor	2	Somatostatin receptor agonist	Unknown	https://conductscience.org/library/genes/6753	Drugs and targets
SSTR4	Somatostatin receptor	2	Somatostatin receptor agonist	Unknown	https://conductscience.org/library/genes/6754	Drugs and targets
SSTR5	Somatostatin receptor	2	Somatostatin receptor agonist	Unknown	https://conductscience.org/library/genes/6755	Drugs and targets

1 to 10 of 59

See all 59 targets

Trials31

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 2 more are not shown, since the checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT02554253	The Impact of Ketamine on Postoperative Cognitive Dysfunction, Delirium, and Renal Dysfunction	Phase 2	52	2022-02-15	Cognitive Disorders, Delirium, Acute Kidney Injury	KETAMINE, PROPOFOL	Its record names the disease	ClinicalTrials.gov
NCT01678794	CR Aim #2 - AT1 Receptor Blockade & ACE Inhibition Effect on Humoral Function	Phase 1/2	33	2021-11-18	Cardiorenal Syndrome (CRS)	CANDESARTAN	Its record names the disease	ClinicalTrials.gov
NCT02058095	Study to Determine How Cialis Effects the Renal Function in Response to Volume Expansion in Preclinical Diastolic Cardiomyopathy (Aim3)	Phase 1/2	22	2020-05-21	Cardiomyopathy, Renal Impairment	TADALAFIL	Its record names the disease	ClinicalTrials.gov
NCT01970176	Study to Determine How Cialis Effects the Renal Function in Response to Volume Expansion in Preclinical Systolic Cardiomyopathy (Aim2)	Phase 1/2	20	2020-07-17	Cardiomyopathy, Renal Impairment	TADALAFIL	Its record names the disease	ClinicalTrials.gov
NCT01709136	Pharmacokinetics of Sirolimus and Tacrolimus in Liver Transplant Recipients With Tacrolimus Toxicity	Phase 2/3	3	2016-04-21	Hypertension	SIROLIMUS	Its record names the disease	ClinicalTrials.gov
NCT03846180	Terlipressin on Effect of Renal Function in Cirrhotic Patients With Acute Gastrointestinal Hemorrhage		1,682		Variceal Hemorrhage, Cirrhosis, Liver, Kidney Injury	OCTREOTIDE, SOMATOSTATIN, TERLIPRESSIN	Its record names the disease	ClinicalTrials.gov
NCT02306213	Effect of Hydroxyethylstarch 6% 130/0.4 Administration on Renal Function After Cardiac Surgery	Not applicable	1,564		Kidney Function Tests	HETASTARCH	Its record names the disease	ClinicalTrials.gov
NCT05298098	Impact of Hypertonic Saline Solution on Acute Decompensated Heart Failure	Not applicable	600		Acute Decompensated Heart Failure	FUROSEMIDE	Its record names the disease	ClinicalTrials.gov
NCT00296309	Comparing Efficacy & Safety of Tacrolimus & MMF With/Without Induction in the Elderly Following Kidney Transplantation.	Phase 3	267		Kidney Transplantation	TACROLIMUS	Its record names the disease	ClinicalTrials.gov
NCT02294292	Therapeutic Approach to Diastolic Dysfunction in Chronic Liver Disease Patients and Its Impact on Morbidity and Mortality	Not applicable	189		Diastolic Dysfunction, Chronic Liver Disease	CARVEDILOL, IVABRADINE	Its record names the disease	ClinicalTrials.gov

1 to 10 of 31

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Comparisons in its trials11

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Ketamine vs Propofol: Number of Patients With Acute Kidney Injury	6 of 25	12 of 24	49	NCT02554253	Trial comparisons
Ketamine vs Propofol: Number of Patients With Postoperative Cognitive Dysfunction	16 of 25	10 of 24	49	NCT02554253	Trial comparisons
Ketamine vs Propofol: Number of Patients Who Develop Postoperative Delirium	0 of 25	1 of 24	49	NCT02554253	Trial comparisons
Ketamine vs Propofol: deaths from any cause	0 of 25	0 of 24	49	NCT02554253	Trial comparisons
Ketamine vs Propofol: serious adverse events	1 of 25	1 of 24	49	NCT02554253	Trial comparisons
Candesartan vs Placebo: deaths from any cause	0 of 16	0 of 17	33	NCT01678794	Trial comparisons
Candesartan vs Placebo: serious adverse events	0 of 16	0 of 17	33	NCT01678794	Trial comparisons
Tadalafil vs Placebo: deaths from any cause	0 of 15	0 of 7	22	NCT02058095	Trial comparisons
Tadalafil vs Placebo: serious adverse events	1 of 15	0 of 7	22	NCT02058095	Trial comparisons
Tadalafil vs Placebo: deaths from any cause	0 of 14	0 of 6	20	NCT01970176	Trial comparisons

1 to 10 of 11

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Papers from its trials22

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
26113208	RESULT	1	PubMed
25613762	RESULT	1	PubMed
25539464	RESULT	1	PubMed
22233522	RESULT	1	PubMed
21931704	RESULT	1	PubMed
19927154	RESULT	1	PubMed
19857743	RESULT	1	PubMed
16407508	RESULT	1	PubMed
7509516	RESULT	1	PubMed
37295665	DERIVED	1	PubMed

1 to 10 of 22

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Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0001343

GET https://conductscience.org/api/diseases/v1/MONDO_0001343/drugs?page=2

API reference For AI assistants