Disease · MONDO_0001422

primary aldosteronism

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. primary aldosteronism. Diseases, record MONDO_0001422. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0001422

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: primary aldosteronism; Open Targets
Open Targets ID: MONDO_0001422; Open Targets
Other names: Conn syndrome, Conn's syndrome, primary hyperaldosteronism; Open Targets
Disease Ontology: DOID:12028; Disease Ontology
NCI Thesaurus: C34510; NCI Thesaurus
Highest stage of its drugs: Phase 3, for 2 of its 11 drugs, from ClinicalTrials.gov; Open Targets

Drugs11

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
SPIRONOLACTONE	CHEMBL1393	Small molecule	Phase 3	ClinicalTrials.gov	5	5	5	Drugs and targets
BAXDROSTAT	CHEMBL4113975	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
AMLODIPINE	CHEMBL1491	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
EVEROLIMUS	CHEMBL1908360	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
OSILODROSTAT	CHEMBL3099695	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
EPLERENONE	CHEMBL1095097	Small molecule	Unknown	ClinicalTrials.gov	2	2	2	Drugs and targets
CANRENONE	CHEMBL1463345	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
CINNARIZINE	CHEMBL43064	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
NIFEDIPINE	CHEMBL193	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
OLMESARTAN	CHEMBL1516	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets

1 to 10 of 11

See all 11 drugs

Targets9

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
NR3C2	Mineralocorticoid receptor	4	Mineralocorticoid receptor antagonist	Phase 3	https://conductscience.org/library/genes/4306	Drugs and targets
CACNA1C	Voltage-gated L-type calcium channel	3	Voltage-gated L-type calcium channel blocker	Phase 2	https://conductscience.org/library/genes/775	Drugs and targets
CACNA1D	Voltage-gated L-type calcium channel	3	Voltage-gated L-type calcium channel blocker	Phase 2	https://conductscience.org/library/genes/776	Drugs and targets
CACNA1F	Voltage-gated L-type calcium channel	3	Voltage-gated L-type calcium channel blocker	Phase 2	https://conductscience.org/library/genes/778	Drugs and targets
CACNA1S	Voltage-gated L-type calcium channel	3	Voltage-gated L-type calcium channel blocker	Phase 2	https://conductscience.org/library/genes/779	Drugs and targets
AGTR1	Type-1 angiotensin II receptor	1	Type-1 angiotensin II receptor antagonist	Unknown	https://conductscience.org/library/genes/185	Drugs and targets
CYP11B1	Cytochrome P450 11B1, mitochondrial	1	Cytochrome P450 11B1 inhibitor	Phase 2	https://conductscience.org/library/genes/1584	Drugs and targets
FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	1	FK506-binding protein 1A inhibitor	Phase 2	https://conductscience.org/library/genes/2280	Drugs and targets
HRH1	Histamine H1 receptor	1	Histamine H1 receptor antagonist	Unknown	https://conductscience.org/library/genes/3269	Drugs and targets

Trials14

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT04179019	Calcium Channel Blockade in Primary Aldosteronism	Phase 2	15	2025-04-15	Primary Aldosteronism, Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral)	AMLODIPINE	Its record names the disease	ClinicalTrials.gov
NCT04605549	A Study of CIN-107 in Adults With Primary Aldosteronism	Phase 2	15	2026-03-03	Primary Aldosteronism, Hyperaldosteronism	BAXDROSTAT	Its record names the disease	ClinicalTrials.gov
NCT07137364	Efficacy of Spironolactone Combined With Antihypertensive Drugs in Patients With Primary Aldosteronism		350		Primary Aldosteronism, Hypertension	SPIRONOLACTONE	Its record names the disease	ClinicalTrials.gov
NCT07007793	Parent Study: A Study to Assess Efficacy and Safety of Baxdrostat in Participants With Primary Aldosteronism Sub-study: A Follow-up Substudy After Completion of the BaxPA Main Study.	Phase 3	212		Primary Hyperaldosteronism	BAXDROSTAT	Its record names the disease	ClinicalTrials.gov
NCT05561361	The Effect of SAAE on Vascular Endothelial Function in PA Patients		200		Primary Aldosteronism	SPIRONOLACTONE	Its record names the disease	ClinicalTrials.gov
NCT05501080	The Effect of SAAE on Ventricular Remodeling in PA Patients	Not applicable	112		Primary Aldosteronism	SPIRONOLACTONE	Its record names the disease	ClinicalTrials.gov
NCT05797558	Unilateral Primary Aldosteronism, Mineralocorticoid Antagonists Versus Surgical Treatment	Not applicable	80		Primary Hyperaldosteronism Due to Adrenal Adenoma	EPLERENONE	Its record names the disease	ClinicalTrials.gov
NCT04185857	MRA and ARB Treatment in Screening of Primary Aldosteronism		50		Primary Aldosteronism Due to Aldosterone Producing Adenoma	CANRENONE, OLMESARTAN	Its record names the disease	ClinicalTrials.gov
NCT02885662	Study of CS-3150 in Patients With Primary Aldosteronism	Not applicable	44		Primary Aldosteronism	XL550	Its record names the disease	ClinicalTrials.gov
NCT03660397	Adrenal Artery Ablation for Uncontrolled Hypertension	Phase 3	40		Uncontrolled Hypertension	SPIRONOLACTONE	Its record names the disease	ClinicalTrials.gov

1 to 10 of 14

See all 14 trials

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials11

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
30518805	RESULT	1	PubMed
30007283	RESULT	1	PubMed
26934393	RESULT	2	PubMed
22146510	RESULT	1	PubMed
18539224	RESULT	1	PubMed
17161262	RESULT	1	PubMed
41773968	DERIVED	1	PubMed
40052842	DERIVED	1	PubMed
37490693	DERIVED	1	PubMed
24107737	DERIVED	1	PubMed

1 to 10 of 11

See all 11 papers from its trials

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0001422

GET https://conductscience.org/api/diseases/v1/MONDO_0001422/drugs

API reference For AI assistants