Disease · MONDO_0006373

pituitary gland adenoma

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. pituitary gland adenoma. Diseases, record MONDO_0006373. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0006373

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: pituitary gland adenoma; Open Targets
Open Targets ID: MONDO_0006373; Open Targets
Other names: adenoma of pituitary, adenoma of pituitary gland, adenoma of the pituitary, adenoma of the pituitary gland, adenoma, anterior lobe pituitary gland, benign, pituitary adenoma; Open Targets
Disease Ontology: DOID:3829; Disease Ontology
NCI Thesaurus: C3329; NCI Thesaurus
Orphanet: ORPHA:99408; Orphanet
Highest stage of its drugs: Phase 3, for 1 of its 12 drugs, from ClinicalTrials.gov; Open Targets

Drugs12

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
LANREOTIDE	CHEMBL1201185	Protein	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
TEMOZOLOMIDE	CHEMBL810	Small molecule	Phase 2/3	ClinicalTrials.gov	2	2	2	Drugs and targets
CAPECITABINE	CHEMBL1773	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
FARLETUZUMAB	CHEMBL1743016	Antibody	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
ROSIGLITAZONE MALEATE	CHEMBL843	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
ONZIGOLIDE	CHEMBL4650342		Phase 2	TTD	1	0	0	Drugs and targets
SODIUM CHLORIDE	CHEMBL1200574	Small molecule	Phase 1	ClinicalTrials.gov	2	2	2	Drugs and targets
DESFLURANE	CHEMBL1200733	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
HYDROCORTISONE	CHEMBL389621	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
OCTREOTIDE	CHEMBL1680	Protein	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets

1 to 10 of 12

See all 12 drugs

Targets33

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
SSTR2	Somatostatin receptor	3	Somatostatin receptor 2 agonist; Somatostatin receptor agonist	Phase 3	https://conductscience.org/library/genes/6752	Drugs and targets
SSTR5	Somatostatin receptor	3	Somatostatin receptor 5 agonist; Somatostatin receptor agonist	Phase 3	https://conductscience.org/library/genes/6755	Drugs and targets
GABRA1	GABA-A receptor; anion channel	2	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2554	Drugs and targets
GABRA2	GABA-A receptor; anion channel	2	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2555	Drugs and targets
GABRA3	GABA-A receptor; anion channel	2	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2556	Drugs and targets
GABRA4	GABA-A receptor; anion channel	2	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2557	Drugs and targets
GABRA5	GABA-A receptor; anion channel	2	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2558	Drugs and targets
GABRA6	GABA-A receptor; anion channel	2	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2559	Drugs and targets
GABRB1	GABA-A receptor; anion channel	2	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2560	Drugs and targets
GABRB2	GABA-A receptor; anion channel	2	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2561	Drugs and targets

1 to 10 of 33

See all 33 targets

Trials10

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT00616642	Rosiglitazone in Treating Patients With Pituitary Tumors	Phase 2	1	2013-04-15	Brain and Central Nervous System Tumors	ROSIGLITAZONE MALEATE	Its record names the disease	ClinicalTrials.gov
NCT03930771	Capecitabine and Temozolomide for Treatment of Recurrent Pituitary Adenomas	Phase 2	1	2022-08-09	Recurrent Pituitary Adenomas	CAPECITABINE, TEMOZOLOMIDE	Its record names the disease	ClinicalTrials.gov
NCT04621565	Hydrocortisone Use During Peri-operation for Pituitary Adenomas	Not applicable	436		Pituitary Adenoma, Adrenal Insufficiency, Surgery	HYDROCORTISONE, SODIUM CHLORIDE	Its record names the disease	ClinicalTrials.gov
NCT04244708	The Effect of Chemoradiotherapy in Patients With Refractory Pituitary Adenomas	Phase 2/3	150		Pituitary Adenomas	TEMOZOLOMIDE	Open Targets' reading of its record	ClinicalTrials.gov
NCT05088252	Desflurane and Anesthesia Recovery Period in Endonasal Endoscopic Pituitary Adenoma Resection	Not applicable	112		Pituitary Neoplasms	DESFLURANE, PROPOFOL	Its record names the disease	ClinicalTrials.gov
NCT03439709	Multicenter Evaluation of the Effect of Upfront Radiosurgery on Residual Growth Hormone-secreting Pituitary Adenoma	Phase 3	90		Acromegaly Due to Pituitary Adenoma	LANREOTIDE	Its record names the disease	ClinicalTrials.gov
NCT01029275	Somatostatin Analog Treatment of Acromegaly Before Pituitary Surgery : Comparison With Neurosurgery Alone	Not applicable	89		Acromegaly	OCTREOTIDE	Its record names the disease	ClinicalTrials.gov
NCT05161780	Evaluation of Endoscopic Surgical Field Clarity Using Hot Saline Versus Lactated Ringer's Irrigation	Phase 1	47		Irrigation	SODIUM CHLORIDE	Its record names the disease	ClinicalTrials.gov
NCT03309319	A Pilot Study of Rosiglitazone in the Treatment of GH Secreting Pituitary Adenomas	Not applicable	24		Pituitary Tumor	ROSIGLITAZONE	Open Targets' reading of its record	ClinicalTrials.gov
NCT01203618	Exploratory Study of Farletuzumab to Treat Resectable, Non-functioning Pituitary Adenomas	Phase 2	0		Resectable, Non-functioning Pituitary Adenoma	FARLETUZUMAB	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials2

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
36856733	DERIVED	1	PubMed
36383383	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0006373

GET https://conductscience.org/api/diseases/v1/MONDO_0006373/targets?page=2

API reference For AI assistants