Disease · MONDO_0006662

aseptic meningitis

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. aseptic meningitis. Diseases, record MONDO_0006662. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0006662

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: aseptic meningitis; Open Targets
Open Targets ID: MONDO_0006662; Open Targets
Other names: Aseptic meningitis (disorder), Meningitis, Aseptic, acute aseptic meningitis; Open Targets
Disease Ontology: DOID:12157; Disease Ontology
MeSH: D008582; MeSH
NCI Thesaurus: C118299; NCI Thesaurus
Highest stage of its drugs: Phase 1/2, for 1 of its 7 drugs, from ClinicalTrials.gov; Open Targets

Drugs7

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
BEVACIZUMAB	CHEMBL1201583	Antibody	Phase 1/2	ClinicalTrials.gov	1	1	1	Drugs and targets
CYTARABINE	CHEMBL803	Small molecule	Phase 1	ClinicalTrials.gov	1	1	1	Drugs and targets
TEMOZOLOMIDE	CHEMBL810	Small molecule	Phase 1	ClinicalTrials.gov	1	1	1	Drugs and targets
TOPOTECAN	CHEMBL84	Small molecule	Phase 1	ClinicalTrials.gov	1	1	1	Drugs and targets
ACYCLOVIR	CHEMBL184	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
CEFTRIAXONE	CHEMBL161	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
DOXYCYCLINE	CHEMBL1200699	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets

Targets17

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
MMP1	Interstitial collagenase	1	Matrix metalloproteinase-1 inhibitor	Unknown	https://conductscience.org/library/genes/4312	Drugs and targets
MMP13	Collagenase 3	1	Matrix metalloproteinase 13 inhibitor	Unknown	https://conductscience.org/library/genes/4322	Drugs and targets
MMP7	Matrilysin	1	Matrix metalloproteinase 7 inhibitor	Unknown	https://conductscience.org/library/genes/4316	Drugs and targets
MMP8	Neutrophil collagenase	1	Matrix metalloproteinase 8 inhibitor	Unknown	https://conductscience.org/library/genes/4317	Drugs and targets
POLA1	DNA polymerase (alpha/delta/epsilon)	1	DNA polymerase (alpha/delta/epsilon) inhibitor	Phase 1	https://conductscience.org/library/genes/5422	Drugs and targets
POLA2	DNA polymerase (alpha/delta/epsilon)	1	DNA polymerase (alpha/delta/epsilon) inhibitor	Phase 1	https://conductscience.org/library/genes/23649	Drugs and targets
POLD1	DNA polymerase (alpha/delta/epsilon)	1	DNA polymerase (alpha/delta/epsilon) inhibitor	Phase 1	https://conductscience.org/library/genes/5424	Drugs and targets
POLD2	DNA polymerase (alpha/delta/epsilon)	1	DNA polymerase (alpha/delta/epsilon) inhibitor	Phase 1	https://conductscience.org/library/genes/5425	Drugs and targets
POLD3	DNA polymerase (alpha/delta/epsilon)	1	DNA polymerase (alpha/delta/epsilon) inhibitor	Phase 1	https://conductscience.org/library/genes/10714	Drugs and targets
POLD4	DNA polymerase (alpha/delta/epsilon)	1	DNA polymerase (alpha/delta/epsilon) inhibitor	Phase 1	https://conductscience.org/library/genes/57804	Drugs and targets

1 to 10 of 17

See all 17 targets

Trials4

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT00924820	A Pilot Study of Bevacizumab for Neoplastic Meningitis	Phase 1/2	20	2020-12-31	Neoplastic Meningitis	BEVACIZUMAB	Open Targets' reading of its record	ClinicalTrials.gov
NCT02328469	Aseptic Meningoencephalitis in Slovenia		800		Aseptic Meningitis	ACYCLOVIR, CEFTRIAXONE, DOXYCYCLINE	Its record names the disease	ClinicalTrials.gov
NCT00674674	Phase 1 Intrathecal Topotecan for Neoplastic Meningitis	Phase 1	22		Neoplastic Meningitis	TOPOTECAN	Open Targets' reading of its record	ClinicalTrials.gov
NCT00515788	DepoCyt Plus Temozolomide in Patients With Neoplastic Meningitis	Phase 1	11		Neoplastic Meningitis	CYTARABINE, TEMOZOLOMIDE	Open Targets' reading of its record	ClinicalTrials.gov

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials1

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it
21910214	RESULT	1

Source PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0006662

GET https://conductscience.org/api/diseases/v1/MONDO_0006662/drugs

API reference For AI assistants