Disease · MONDO_0018352

squamous cell carcinoma of penis

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. squamous cell carcinoma of penis. Diseases, record MONDO_0018352. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0018352

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: squamous cell carcinoma of penis; Open Targets
Open Targets ID: MONDO_0018352; Open Targets
Other names: epidermoid carcinoma of penis, epidermoid carcinoma of the penis, epidermoid cell carcinoma of penis, epidermoid cell carcinoma of the penis, penile epidermoid carcinoma, penile epidermoid cell carcinoma, penile squamous car.(epidermoid), penile squamous carcinoma (epidermoid), penile squamous cell cancer, penile squamous cell carcinoma, penis squamous cell carcinoma, squamous cell carcinoma of the penis; Open Targets
Disease Ontology: DOID:5518; Disease Ontology
NCI Thesaurus: C7729; NCI Thesaurus
Orphanet: ORPHA:398058; Orphanet
Highest stage of its drugs: Phase 2, for 23 of its 25 drugs, from ClinicalTrials.gov; Open Targets

Drugs25

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
CISPLATIN	CHEMBL11359	Small molecule	Phase 2	ClinicalTrials.gov	4	4	4	Drugs and targets
PEMBROLIZUMAB	CHEMBL3137343	Antibody	Phase 2	ClinicalTrials.gov	4	4	4	Drugs and targets
PACLITAXEL	CHEMBL428647	Small molecule	Phase 2	ClinicalTrials.gov	3	3	3	Drugs and targets
AVELUMAB	CHEMBL3833373	Antibody	Phase 2	ClinicalTrials.gov	2	2	2	Drugs and targets
BECOTATUG VEDOTIN	CHEMBL6068210	Antibody drug conjugate	Phase 2	ClinicalTrials.gov	2	2	2	Drugs and targets
CABOZANTINIB	CHEMBL2105717	Small molecule	Phase 2	ClinicalTrials.gov	2	2	2	Drugs and targets
CARBOPLATIN	CHEMBL1351	Small molecule	Phase 2	ClinicalTrials.gov	2	2	2	Drugs and targets
ENFORTUMAB VEDOTIN	CHEMBL3301589	Antibody drug conjugate	Phase 2	ClinicalTrials.gov	2	2	2	Drugs and targets
IFOSFAMIDE	CHEMBL1024	Small molecule	Phase 2	ClinicalTrials.gov	2	2	2	Drugs and targets
PUCOTENLIMAB	CHEMBL4650472	Antibody	Phase 2	ClinicalTrials.gov	2	2	2	Drugs and targets

1 to 10 of 25

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Targets47

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
PDCD1	Programmed cell death protein 1	6	Programmed cell death protein 1 antagonist; Programmed cell death protein 1 inhibitor	Phase 2	https://conductscience.org/library/genes/5133	Drugs and targets
TUBA1A	Tubulin	3	Tubulin inhibitor	Phase 2	https://conductscience.org/library/genes/7846	Drugs and targets
TUBA1B	Tubulin	3	Tubulin inhibitor	Phase 2	https://conductscience.org/library/genes/10376	Drugs and targets
TUBA1C	Tubulin	3	Tubulin inhibitor	Phase 2	https://conductscience.org/library/genes/84790	Drugs and targets
TUBA3C	Tubulin	3	Tubulin inhibitor	Phase 2	https://conductscience.org/library/genes/7278	Drugs and targets
TUBA3E	Tubulin	3	Tubulin inhibitor	Phase 2	https://conductscience.org/library/genes/112714	Drugs and targets
TUBA4A	Tubulin	3	Tubulin inhibitor	Phase 2	https://conductscience.org/library/genes/7277	Drugs and targets
TUBB	Tubulin	3	Tubulin inhibitor	Phase 2	https://conductscience.org/library/genes/203068	Drugs and targets
TUBB1	Tubulin	3	Tubulin inhibitor	Phase 2	https://conductscience.org/library/genes/81027	Drugs and targets
TUBB2A	Tubulin	3	Tubulin inhibitor	Phase 2	https://conductscience.org/library/genes/7280	Drugs and targets

1 to 10 of 47

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Trials23

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT00512096	Neoadjuvant Chemotherapy for Patients With Squamous Cell Carcinoma of the Penis	Phase 2	30	2010-12-08	Penile Cancer	CISPLATIN, IFOSFAMIDE, PACLITAXEL	Its record names the disease	ClinicalTrials.gov
NCT04231981	Efficacy of INCMGA00012 in Penile Squamous Cell Carcinoma (ORPHEUS)	Phase 2	18	2025-05-29	Penile Cancer	RETIFANLIMAB	Its record names the disease	ClinicalTrials.gov
NCT02541903	Trial Using Gilotrif for Advanced Penile Squamous Cell Carcinoma	Phase 2	8	2020-04-14	Penile Squamous Cell Carcinoma (PSCC)	AFATINIB	Its record names the disease	ClinicalTrials.gov
NCT02837042	Trial of Pembrolizumab for Advanced Penile Squamous Cell Carcinoma	Phase 2	6	2022-06-21	Penile Squamous Cell Carcinoma	PEMBROLIZUMAB	Its record names the disease	ClinicalTrials.gov
NCT02496208	Cabozantinib S-malate and Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Genitourinary Tumors	Phase 1	152		Bladder Small Cell Neuroendocrine Carcinoma, Bladder Squamous Cell Carcinoma, Bladder Urothelial Carcinoma, Clear Cell Renal Cell Carcinoma, Invasive Bladder Plasmacytoid Urothelial Carcinoma, Invasive Bladder Sarcomatoid Urothelial Carcinoma, Invasive Sarcomatoid Urothelial Carcinoma, Kidney Medullary Carcinoma, Malignant Genitourinary System Neoplasm, Malignant Solid Neoplasm, Penile Carcinoma, Penile Squamous Cell Carcinoma, Renal Cell Carcinoma, Renal Pelvis Urothelial Carcinoma, Sarcomatoid Renal Cell Carcinoma, Stage III Bladder Cancer AJCC v8, Stage III Penile Cancer AJCC v8, Stage III Renal Cell Cancer AJCC v8, Stage III Renal Pelvis and Ureter Cancer AJCC v8, Stage III Renal Pelvis Cancer AJCC v8, Stage III Ureter Cancer AJCC v8, Stage III Urethral Cancer AJCC v8, Stage IV Bladder Cancer AJCC v8, Stage IV Penile Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v8, Stage IV Renal Pelvis and Ureter Cancer AJCC v8, Stage IV Ureter Cancer AJCC v8, Stage IV Urethral Cancer AJCC v8, Ureter Urothelial Carcinoma, Urethral Urothelial Carcinoma	CABOZANTINIB, IPILIMUMAB, NIVOLUMAB	Its record names the disease	ClinicalTrials.gov
NCT04357873	Efficacy of Immunotherapy Plus a Drug in Patients With Progressive Advanced Mucosal Cancer of Different Locations	Phase 2	112		Squamous Cell Lung Cancer, Vulvar Cancer, Penile Cancer, Cervix Cancer, Head and Neck Squamous Cell Carcinoma, Anal Cancer	PEMBROLIZUMAB, VORINOSTAT	Its record names the disease	ClinicalTrials.gov
NCT01807546	Oral Rigosertib for Squamous Cell Carcinoma	Phase 2	64		Head and Neck Squamous Cell Carcinoma, Anal Squamous Cell Carcinoma, Lung Squamous Cell Carcinoma, Cervical Squamous Cell Carcinoma, Esophageal Squamous Cell Carcinoma, Skin Squamous Cell Carcinoma, Penile Squamous Cell Carcinoma	RIGOSERTIB	Its record names the disease	ClinicalTrials.gov
NCT07518979	EGFR-ADC (Becotatug Vedotin) Combined With PD-1 Inhibitor (Pucotenlimab) in Neoadjuvant Treatment of Advanced Penile Cancer	Phase 2	60		Penile Cancer	BECOTATUG VEDOTIN, PUCOTENLIMAB	Its record names the disease	ClinicalTrials.gov
NCT00210041	Phase 2 Study of Association Gemcitabine-Cisplatin to Treat Penis Epidermoid Carcinoma	Phase 2	50		Genital Neoplasms, Male	CISPLATIN, GEMCITABINE	Open Targets' reading of its record	ClinicalTrials.gov
NCT07384416	QL1706 Plus Lenvatinib in Previously Treated Penile Cancer	Phase 2	47		Penile Cancer	LENVATINIB	Its record names the disease	ClinicalTrials.gov

1 to 10 of 23

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Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials12

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
25601543	RESULT	1	PubMed
20625118	RESULT	1	PubMed
42757773	DERIVED	1	PubMed
41468684	DERIVED	1	PubMed
41163621	DERIVED	1	PubMed
40965911	DERIVED	1	PubMed
40588522	DERIVED	1	PubMed
38954785	DERIVED	1	PubMed
37487169	DERIVED	1	PubMed
35031545	DERIVED	1	PubMed

1 to 10 of 12

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Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0018352

GET https://conductscience.org/api/diseases/v1/MONDO_0018352/drugs?page=2

API reference For AI assistants