Drug · CHEMBL742

KETAMINE

7 sourcespipelines-2026-09-18-0.3.1

Cite this record

ConductScience Library. KETAMINE. Drugs and targets, record CHEMBL742. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL742

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Drug

Names and IDs as ChEMBL gives them, through Open Targets.

Name: KETAMINE; ChEMBL
ChEMBL ID: CHEMBL742; ChEMBL
Type: Small molecule; ChEMBL
Brand names: Ketalar, Ketamine component of ketafol; ChEMBL
Other names: Anaket v, Calypsol, Clorketam 1000, Dl-ketamine, Imalgene 1000, Ketamina, Ketasol 100, NSC-70151, Narketan, PMI-150, Tekam, Ursotamin, Vetaket; ChEMBL
Other form: KETAMINE HYDROCHLORIDE, CHEMBL1714; Drugs and targets
DrugBank: DB01221; DrugBank
InChIKey: YQEZLKZALYSWHR-UHFFFAOYSA-N; ChEMBL
Open Targets' highest stage: Approval, as Open Targets' drug record gives it; Open Targets

Targets7

The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.

Target	Protein	Mechanism	Action	Gene in Genes
GRIN1	Glutamate [NMDA] receptor	Glutamate [NMDA] receptor negative allosteric modulator	NEGATIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/2902
GRIN2A	Glutamate [NMDA] receptor	Glutamate [NMDA] receptor negative allosteric modulator	NEGATIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/2903
GRIN2B	Glutamate [NMDA] receptor	Glutamate [NMDA] receptor negative allosteric modulator	NEGATIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/2904
GRIN2C	Glutamate [NMDA] receptor	Glutamate [NMDA] receptor negative allosteric modulator	NEGATIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/2905
GRIN2D	Glutamate [NMDA] receptor	Glutamate [NMDA] receptor negative allosteric modulator	NEGATIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/2906
GRIN3A	Glutamate [NMDA] receptor	Glutamate [NMDA] receptor negative allosteric modulator	NEGATIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/116443
GRIN3B	Glutamate [NMDA] receptor	Glutamate [NMDA] receptor negative allosteric modulator	NEGATIVE ALLOSTERIC MODULATOR	https://conductscience.org/library/genes/116444

Source ChEMBL

Diseases117

The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Disease	Open Targets' stage	Stage reported by	Reports	Of them trials	Its drugs
major depressive disorder	Phase 3	ClinicalTrials.gov	133	133	https://conductscience.org/library/drugs?q=MONDO_0002009
depressive disorder	Phase 3	ClinicalTrials.gov	83	83	https://conductscience.org/library/drugs?q=MONDO_0002050
Pain	Phase 3	ClinicalTrials.gov	47	47	https://conductscience.org/library/drugs?q=HP_0012531
suicidal ideation	Phase 3	ClinicalTrials.gov	35	35	https://conductscience.org/library/drugs?q=EFO_0004320
post-traumatic stress disorder	Phase 3	ClinicalTrials.gov	22	22	https://conductscience.org/library/drugs?q=MONDO_0005146
bipolar disorder	Phase 3	ClinicalTrials.gov	18	18	https://conductscience.org/library/drugs?q=MONDO_0004985
anxiety	Phase 3	ClinicalTrials.gov	12	12	https://conductscience.org/library/drugs?q=MONDO_0011918
obsessive-compulsive disorder	Phase 2	ClinicalTrials.gov	11	11	https://conductscience.org/library/drugs?q=MONDO_0008114
Chronic pain	Phase 3	ClinicalTrials.gov	9	9	https://conductscience.org/library/drugs?q=HP_0012532
alcohol dependence	Phase 2/3	ClinicalTrials.gov	9	9	https://conductscience.org/library/drugs?q=MONDO_0007079

1 to 10 of 117Source Open Targets

See all 117 diseases

Trials1,209

Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs. 2 more rest on that reading alone and are shown because the trials' posted result groups or NLM's indexing of their papers name the drug. 5 more that Open Targets linked to it are not shown, since the release's checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Named as	Linked by	Source
NCT02625181	Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis		27,034	2019-03-07	ketamine	Its name	ClinicalTrials.gov
NCT05604794	A Retrospective Effectiveness Trial of Ketamine-Assisted Psychotherapy in Adult Patients Coping With Mental Health	Phase 4	1,806	2023-05-12	ketamine	Its name	ClinicalTrials.gov
NCT04625283	The Impact of Perioperative Ketamine Infusion on Surgical Recovery	Phase 4	1,570	2025-02-04	ketamine	Its name	ClinicalTrials.gov
NCT02643381	Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial	Phase 4	801	2021-12-15	ketamine	Its name	ClinicalTrials.gov
NCT01690988	The Prevention of Delirium and Complications Associated With Surgical Treatments Multi Center Clinical Trial	Phase 3	746	2018-05-02	ketamine	Its name	ClinicalTrials.gov
NCT00471445	Topical Amitriptyline and Ketamine Cream in Treating Peripheral Neuropathy Caused by Chemotherapy in Cancer Patients	Phase 3	462	2015-06-10	ketamine	Its name	ClinicalTrials.gov
NCT03545503	Evaluating the Hemodynamic Effects of Ketamine Versus Etomidate During Rapid Sequence Intubation	Phase 4	428	2021-11-26	ketamine	Its name	ClinicalTrials.gov
NCT03113968	ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD)	Phase 2/3	403	2023-08-09	ketamine	Its name	ClinicalTrials.gov
NCT00475904	A Comparison of EpiCept™ NP-1 Topical Cream vs. Oral Gabapentin in Postherpetic Neuralgia (PHN)	Phase 2	360	2011-07-06	ketamine	Its name	ClinicalTrials.gov
NCT04129086	Ketamine for Acute Pain Management After Trauma	Phase 4	305	2023-04-21	ketamine	Its name	ClinicalTrials.gov

1 to 10 of 1,209

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Comparisons in its trials350

Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Ketamine vs Saline: Number of Participants Who Experienced ICU Transfer	44 of 770	22 of 752	1,522	NCT04625283	Trial comparisons
Ketamine vs Saline: Number of Participants With Ileus	71 of 770	37 of 752	1,522	NCT04625283	Trial comparisons
Ketamine vs Saline: Number of Participants Who Encounter Rapid Response Team Activation	39 of 770	26 of 752	1,522	NCT04625283	Trial comparisons
Ketamine vs Saline: deaths from any cause	1 of 770	0 of 752	1,522	NCT04625283	Trial comparisons
Ketamine vs Saline: serious adverse events	0 of 770	1 of 752	1,522	NCT04625283	Trial comparisons
Etomidate vs Ketamine: Survival at Day 28	254 of 396	264 of 395	791	NCT02643381	Trial comparisons
Etomidate vs Ketamine: Number of Participants With New Diagnosis of Adrenal Insufficiency	11 of 396	4 of 395	791	NCT02643381	Trial comparisons
Etomidate vs Ketamine: Survival at Day 7	306 of 396	336 of 395	791	NCT02643381	Trial comparisons
Etomidate vs Ketamine: deaths from any cause	142 of 396	131 of 395	791	NCT02643381	Trial comparisons
Etomidate vs Ketamine: serious adverse events	10 of 396	9 of 395	791	NCT02643381	Trial comparisons

1 to 10 of 350

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Papers from its trials738

The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
42421175	RESULT	1	PubMed
39564442	RESULT	1	PubMed
39386403	RESULT	1	PubMed
38337458	RESULT	1	PubMed
38293492	RESULT	1	PubMed
38285446	RESULT	2	PubMed
37857620	RESULT	1	PubMed
37404968	RESULT	1	PubMed
37363462	RESULT	1	PubMed
37302533	RESULT	1	PubMed

1 to 10 of 738

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Tests in its trials35

The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.

Test	Trials naming it as an outcome	As a primary outcome	Source
Verbal Learning	11	3	ConductCognition
Verbal Fluency	7	2	ConductCognition
Stroop Color-Word Test	6	2	ConductCognition
Digit Span Test	5	3	ConductCognition
Trail Making Test A	5	1	ConductCognition
Food Cue Reactivity Task	4	1	ConductCognition
Implicit Association Test (IAT)	4	1	ConductCognition
Trail Making Test B	4	1	ConductCognition
1-Back Task	3	1	ConductCognition
2-Back Task	3	1	ConductCognition

1 to 10 of 35

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Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
ClinicalTrials.gov: 2026-11-05; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
Papers the trials list, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
Tests named in the trials, as ScienceGraph matched them: 2026-11-12; ConductCognition

Sources 7

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ConductCognition's list of its testsOur own data
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this drug from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/drugs/v1/CHEMBL742

GET https://conductscience.org/api/drugs/v1/CHEMBL742/diseases?page=2

API reference For AI assistants