Paper · 21984977

Functional viability profiles of breast cancer.

Brough R and 21 others. Cancer Discov, 2011. Cited by 123 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Functional viability profiles of breast cancer. Papers, record 21984977. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/21984977

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Functional viability profiles of breast cancer.; PubMed
Journal: Cancer Discov; PubMed
Year: 2011; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/21984977/; PubMed
DOI: https://doi.org/10.1158/2159-8290.cd-11-0107; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC3188379/; PubMed
The journal: https://conductscience.org/library/journal-index/101561693; PubMed
Citations, by iCite: 123; iCite
Relative citation ratio, by iCite: 2.35; iCite
Revised in PubMed: 2025-05-29; PubMed

Authors22

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Brough R	Rachel
2	Frankum JR	Jessica R
3	Sims D	David
4	Mackay A	Alan
5	Mendes-Pereira AM	Ana M
6	Bajrami I	Ilirjana
7	Costa-Cabral S	Sara
8	Rafiq R	Rumana
9	Ahmad AS	Amar S
10	Cerone MA	Maria Antonietta

1 to 10 of 22Source PubMed

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Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Breast Neoplasms	Major topic
Cell Line, Tumor
Female
Gene Expression Profiling
Genetic Testing
Humans
M Phase Cell Cycle Checkpoints
Mutation
PTEN Phosphohydrolase
Protein Kinases
Receptors, Estrogen

Source PubMed

Grants4

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
11566	Cancer Research UK	United Kingdom		PubMed	PubMed
A8363	Cancer Research UK	United Kingdom		PubMed	PubMed
BREAST CANCER NOW RESEARCH CENTRE	Breast Cancer Now	United Kingdom		PubMed	PubMed
P30 CA082103	NCI NIH HHS	United States	P30CA082103	PubMed and NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

Kind	PMID	Title	In Papers
Comment in	22,586,571	Functional subtyping of breast cancer.	https://conductscience.org/library/papers/22586571

Source PubMed

References42

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	10,838,414	A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays.	J Biomol Screen	1999	https://conductscience.org/library/papers/10838414	PubMed
2	18,388,863	A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor.	EMBO J	2008	https://conductscience.org/library/papers/18388863	PubMed
3	19,903,845	Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase.	Cancer Res	2009	https://conductscience.org/library/papers/19903845	PubMed
4	20,029,424	A census of amplified and overexpressed human cancer genes.	Nat Rev Cancer	2010	https://conductscience.org/library/papers/20029424	PubMed
5	18,239,126	Cancer proliferation gene discovery through functional genomics.	Science	2008	https://conductscience.org/library/papers/18239126	PubMed
6	19,536,107	Novel anticancer targets: revisiting ERBB2 and discovering ERBB3.	Nat Rev Cancer	2009	https://conductscience.org/library/papers/19536107	PubMed
7	2,218,183	More powerful procedures for multiple significance testing.	Stat Med	1990	https://conductscience.org/library/papers/2218183	PubMed
8	11,553,815	Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications.	Proc Natl Acad Sci U S A	2001	https://conductscience.org/library/papers/11553815	PubMed
9	20,049,735	Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors.	EMBO Mol Med	2009	https://conductscience.org/library/papers/20049735	PubMed
10	20,453,858	53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers.	Nat Struct Mol Biol	2010	https://conductscience.org/library/papers/20453858	PubMed

1 to 10 of 42

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Cited by84

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 123 citations.

PMID	Title	Journal	Year	In Papers	Source
42,068,645	Genetically predicted TTK inhibition and its association with reduced breast cancer risk: a two-step Mendelian randomization study of potential gut microbiome mediation.	Clinics (Sao Paulo)	2026	https://conductscience.org/library/papers/42068645	PubMed
40,565,246	The ADCK Kinase Family: Key Regulators of Bioenergetics and Mitochondrial Function and Their Implications in Human Cancers.	Int J Mol Sci	2025	https://conductscience.org/library/papers/40565246	PubMed
37,533,462	Synthetic lethal approaches to target cancers with loss of PTEN function.	Genes Dis	2023	https://conductscience.org/library/papers/37533462	PubMed
37,443,114	BID expression determines the apoptotic fate of cancer cells after abrogation of the spindle assembly checkpoint by AURKB or TTK inhibitors.	Mol Cancer	2023	https://conductscience.org/library/papers/37443114	PubMed
37,346,953	New cyclic glycolipids from Silene succulenta promote in vitro MCF-7 breast carcinoma cell apoptosis by cell cycle arrest and in silico mitotic Mps1/TTK inhibition.	RSC Adv	2023	https://conductscience.org/library/papers/37346953	PubMed
37,190,140	The CDK4/6 Inhibitor Palbociclib Inhibits Estrogen-Positive and Triple Negative Breast Cancer Bone Metastasis In Vivo.	Cancers (Basel)	2023	https://conductscience.org/library/papers/37190140	PubMed
36,934,096	Synthetic lethality of drug-induced polyploidy and BCL-2 inhibition in lymphoma.	Nat Commun	2023	https://conductscience.org/library/papers/36934096	PubMed
36,439,873	Identification of the mitochondrial protein ADCK2 as a therapeutic oncotarget of NSCLC.	Int J Biol Sci	2022	https://conductscience.org/library/papers/36439873	PubMed
36,405,310	Combined 3D-QSAR, molecular docking and dynamics simulations studies to model and design TTK inhibitors.	Front Chem	2022	https://conductscience.org/library/papers/36405310	PubMed
36,085,291	Comparison of the mutational profiles of neuroendocrine breast tumours, invasive ductal carcinomas and pancreatic neuroendocrine carcinomas.	Oncogenesis	2022	https://conductscience.org/library/papers/36085291	PubMed

1 to 10 of 84

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Genes41

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
ADCK2	90,956	PubTator's text mining	https://conductscience.org/library/genes/90956	NCBI Gene
AKT1	207	PubTator's text mining	https://conductscience.org/library/genes/207	NCBI Gene
AKT2	208	PubTator's text mining	https://conductscience.org/library/genes/208	NCBI Gene
AKT3	10,000	PubTator's text mining	https://conductscience.org/library/genes/10000	NCBI Gene
AURKA	6,790	PubTator's text mining	https://conductscience.org/library/genes/6790	NCBI Gene
BRAF	673	PubTator's text mining	https://conductscience.org/library/genes/673	NCBI Gene
BRCA1	672	PubTator's text mining	https://conductscience.org/library/genes/672	NCBI Gene
CAMK1	8,536	PubTator's text mining	https://conductscience.org/library/genes/8536	NCBI Gene
CCND1	595	PubTator's text mining	https://conductscience.org/library/genes/595	NCBI Gene
CDK4	1,019	PubTator's text mining	https://conductscience.org/library/genes/1019	NCBI Gene

1 to 10 of 41

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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