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Paper · 30894200

Longitudinal heterogeneity in glioblastoma: moving targets in recurrent versus primary tumors.

Schäfer N and 12 others. J Transl Med, 2019. Cited by 51 papers, by iCite.

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ConductScience Library. Longitudinal heterogeneity in glioblastoma: moving targets in recurrent versus primary tumors. Papers, record 30894200. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/30894200

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Longitudinal heterogeneity in glioblastoma: moving targets in recurrent versus primary tumors.
PubMed
Journal
J Transl Med
PubMed
Year
2019
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
51
iCite
Relative citation ratio, by iCite
1.86
iCite
Revised in PubMed
2020-05-05
PubMed

Authors13

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Schäfer NNiklashttps://orcid.org/0000-0002-2258-0275
2Gielen GHGerrit H
3Rauschenbach LLaurèl
4Kebir SSied
5Till AAndreas
6Reinartz RRoman
7Simon MMatthias
8Niehusmann PPitt
9Kleinschnitz CChristoph
10Herrlinger UUlrich

1 to 10 of 13Source PubMed

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Topics20

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Biomarkers, TumorMajor topic
Brain NeoplasmsMajor topic
Genetic HeterogeneityMajor topic
GlioblastomaMajor topic
Molecular Targeted TherapyMajor topic
Neoplasm Recurrence, LocalMajor topic
Adult
Aged
Antineoplastic Agents
Antineoplastic Agents, Immunological
Disease Progression
Epigenesis, Genetic
Female
Humans
Longitudinal Studies
Male
Middle Aged
Patient Care Planning
Retrospective Studies
Young Adult

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References40

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
122,137,795Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma.Cancer Cell2011https://conductscience.org/library/papers/22137795PubMed
223,964,934Pazopanib versus sunitinib in metastatic renal-cell carcinoma.N Engl J Med2013https://conductscience.org/library/papers/23964934PubMed
328,031,556Advances in the molecular genetics of gliomas - implications for classification and therapy.Nat Rev Clin Oncol2017https://conductscience.org/library/papers/28031556PubMed
425,231,549Genetic Analysis of Diffuse High-Grade Astrocytomas in Infancy Defines a Novel Molecular Entity.Brain Pathol2015https://conductscience.org/library/papers/25231549PubMed
526,381,530Everolimus for subependymal giant cell astrocytoma: 5-year final analysis.Ann Neurol2015https://conductscience.org/library/papers/26381530PubMed
626,373,279Spatiotemporal Evolution of the Primary Glioblastoma Genome.Cancer Cell2015https://conductscience.org/library/papers/26373279PubMed
721,425,258Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas.Int J Cancer2011https://conductscience.org/library/papers/21425258PubMed
823,940,216Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma.J Clin Oncol2013https://conductscience.org/library/papers/23940216PubMed
922,323,597Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response.Proc Natl Acad Sci U S A2012https://conductscience.org/library/papers/22323597PubMed
1026,061,753Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors.N Engl J Med2015https://conductscience.org/library/papers/26061753PubMed

1 to 10 of 40

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Cited by46

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 51 citations.

PMIDTitleJournalYearIn PapersSource
42,974,574Comparative barriers to molecular therapy and immunotherapy in glioblastoma: A systematic review.Surg Neurol Int2026https://conductscience.org/library/papers/42974574PubMed
42,908,192Oncolytic Virus-Engineered Extracellular Vesicles Rewire Glioblastoma Immunity.J Extracell Vesicles2026https://conductscience.org/library/papers/42908192PubMed
42,897,630Quantitative proteomic landscape reveals the role of CSPG5 in the recurrence of glioma.Cancer Cell Int2026https://conductscience.org/library/papers/42897630PubMed
41,444,392PLX3397 attenuated tumor growth and remodeled tumor microenvironment of recurrent glioblastoma.Sci Rep2025https://conductscience.org/library/papers/41444392PubMed
41,002,392FGFR1 Inhibition by Pemigatinib Enhances Radiosensitivity in Glioblastoma Stem Cells Through S100A4 Downregulation.Cells2025https://conductscience.org/library/papers/41002392PubMed
40,640,872DNA methylation remodeling in temozolomide resistant recurrent glioblastoma: comparing epigenetic dynamics in vitro and in vivo.J Transl Med2025https://conductscience.org/library/papers/40640872PubMed
39,423,857Multidimensional analysis of matched primary and recurrent glioblastoma identifies contributors to tumor recurrence influencing time to relapse.J Neuropathol Exp Neurol2025https://conductscience.org/library/papers/39423857PubMed
39,062,807On the Boundary of Exploratory Genomics and Translation in Sequential Glioblastoma.Int J Mol Sci2024https://conductscience.org/library/papers/39062807PubMed
38,899,374Current status of precision oncology in adult glioblastoma.Mol Oncol2024https://conductscience.org/library/papers/38899374PubMed
38,672,254Isocitrate Dehydrogenase 1/2 Wildtype Adult Astrocytoma with WHO Grade 2/3 Histological Features: Molecular Re-Classification, Prognostic Factors, Clinical Outcomes.Biomedicines2024https://conductscience.org/library/papers/38672254PubMed

1 to 10 of 46

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Genes12

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ALK238PubTator's text mininghttps://conductscience.org/library/genes/238NCBI Gene
EGFR1,956PubTator's text mininghttps://conductscience.org/library/genes/1956NCBI Gene
FGFR12,260PubTator's text mininghttps://conductscience.org/library/genes/2260NCBI Gene
FGFR22,263PubTator's text mininghttps://conductscience.org/library/genes/2263NCBI Gene
FGFR32,261PubTator's text mininghttps://conductscience.org/library/genes/2261NCBI Gene
IDH13,417PubTator's text mininghttps://conductscience.org/library/genes/3417NCBI Gene
KDR3,791PubTator's text mininghttps://conductscience.org/library/genes/3791NCBI Gene
MGMT4,255PubTator's text mininghttps://conductscience.org/library/genes/4255NCBI Gene
MTOR2,475PubTator's text mininghttps://conductscience.org/library/genes/2475NCBI Gene
PDGFRA5,156PubTator's text mininghttps://conductscience.org/library/genes/5156NCBI Gene

1 to 10 of 12

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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