ConductScience.org, home
Papers
API referenceFor AI assistants

Paper36948592

Recombinant Technologies Facilitate Drug Metabolism, Pharmacokinetics, and General Biomedical Research.

Cronin JM and 1 other. Drug Metab Dispos, 2023. Cited by 12 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Download JSON
Cite this record

ConductScience Library. Recombinant Technologies Facilitate Drug Metabolism, Pharmacokinetics, and General Biomedical Research. Papers, record 36948592. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/36948592

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Recombinant Technologies Facilitate Drug Metabolism, Pharmacokinetics, and General Biomedical Research.
PubMed
Journal
Drug Metab Dispos
PubMed
Year
2023
PubMed
Publication types
Journal Article, Review, Research Support, N.I.H., Extramural
PubMed
Citations, by iCite
12
iCite
Relative citation ratio, by iCite
1.4
iCite
Revised in PubMed
2025-02-12
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Cronin JMJoseph Mhttps://orcid.org/0000-0001-5337-0310
2Yu AMAi-Minghttps://orcid.org/0000-0003-1441-4012

Source PubMed

Topics7

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
DNA, RecombinantMajor topic
MicroRNAsMajor topic
RNA, Small Interfering
Metabolic Clearance Rate
Technology
Recombinant Proteins
Pharmacokinetics

Source PubMed

Grants5

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
P30 CA093373NCI NIH HHSUnited StatesP30CA093373PubMedNIH RePORTER
T32 GM144303NIGMS NIH HHSUnited StatesT32GM144303PubMed and NIHNIH RePORTER
R01 CA225958NCI NIH HHSUnited StatesR01CA225958PubMed and NIHNIH RePORTER
R35 GM140835NIGMS NIH HHSUnited StatesR35GM140835PubMed and NIHNIH RePORTER
R01 CA253230NCI NIH HHSUnited StatesR01CA253230PubMed and NIHNIH RePORTER

References165

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
128,900,685Double promoter expression systems for recombinant protein production by industrial microorganisms.Appl Microbiol Biotechnol2017https://conductscience.org/library/papers/28900685PubMed
227,723,879Failure of Investigational Drugs in Late-Stage Clinical Development and Publication of Trial Results.JAMA Intern Med2016https://conductscience.org/library/papers/27723879PubMed
310,678,174Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity.Mol Cell2000https://conductscience.org/library/papers/10678174PubMed
49,788,996Directed evolution of a thermostable esterase.Proc Natl Acad Sci U S A1998https://conductscience.org/library/papers/9788996PubMed
525,161,167Rapid production of novel pre-microRNA agent hsa-mir-27b in Escherichia coli using recombinant RNA technology for functional studies in mammalian cells.Drug Metab Dispos2014https://conductscience.org/library/papers/25161167PubMed
63,310,532P-450 cytochromes: structure and function.Adv Enzymol Relat Areas Mol Biol1987https://conductscience.org/library/papers/3310532PubMed
74,042,523Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations.Clin Pharmacol Ther1985https://conductscience.org/library/papers/4042523PubMed
834,086,286Expression and Purification of tRNA/ pre-miRNA-Based Recombinant Noncoding RNAs.Methods Mol Biol2021https://conductscience.org/library/papers/34086286PubMed
97,487,078A universal approach to the expression of human and rabbit cytochrome P450s of the 2C subfamily in Escherichia coli.Arch Biochem Biophys1995https://conductscience.org/library/papers/7487078PubMed
1014,676,196Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site.J Biol Chem2004https://conductscience.org/library/papers/14676196PubMed
111,123,353Purified liver microsomal cytochrome P-450. Separation and characterization of multiple forms.J Biol Chem1975https://conductscience.org/library/papers/1123353PubMed
1221,219,875Breast cancer resistance protein BCRP/ABCG2 regulatory microRNAs (hsa-miR-328, -519c and -520h) and their differential expression in stem-like ABCG2+ cancer cells.Biochem Pharmacol2011https://conductscience.org/library/papers/21219875PubMed
1312,424,899Purification and crystallization of N-terminally truncated forms of microsomal cytochrome P450 2C5.Methods Enzymol2002https://conductscience.org/library/papers/12424899PubMed
1429,061,583Bioengineered NRF2-siRNA Is Effective to Interfere with NRF2 Pathways and Improve Chemosensitivity of Human Cancer Cells.Drug Metab Dispos2018https://conductscience.org/library/papers/29061583PubMed
1518,295,882Construction and use of new cloning vectors for the rapid isolation of recombinant proteins from Escherichia coli.Plasmid2008https://conductscience.org/library/papers/18295882PubMed
1610,508,682A high-throughput digital imaging screen for the discovery and directed evolution of oxygenases.Chem Biol1999https://conductscience.org/library/papers/10508682PubMed
1728,244,990The chemical evolution of oligonucleotide therapies of clinical utility.Nat Biotechnol2017https://conductscience.org/library/papers/28244990PubMed
1817,125,407Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction.Expert Opin Drug Metab Toxicol2006https://conductscience.org/library/papers/17125407PubMed
1922,266,943Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001.Nature2012https://conductscience.org/library/papers/22266943PubMed
2029,792,703Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2.J Med Chem2018https://conductscience.org/library/papers/29792703PubMed

See all 165 references

Cited by10

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 12 citations.

PMIDTitleJournalYearIn PapersSource
42,395,640Bioengineered miR-148a-3p suppresses glycolysis and amino acid homeostasis in hepatocellular carcinoma cells by regulating multiple solute carrier transporters.Liver Res2026https://conductscience.org/library/papers/42395640PubMed
41,905,330Comparative effectiveness of 7 major human let-7-5p isoforms to modulate target gene expression in liver cells.Drug Metab Dispos2026https://conductscience.org/library/papers/41905330PubMed
41,601,978Characterization of the biodistribution profile of a human Dialyzable Leukocyte Extract (hDLE) by in vivo fluorescence imaging: a strategy to infer the ADME profile of complex multipeptide drugs.Front Pharmacol2025https://conductscience.org/library/papers/41601978PubMed
40,772,015A Comprehensive Review of Theaflavins: Physiological Activities, Synthesis Techniques, and Future Challenges.Food Sci Nutr2025https://conductscience.org/library/papers/40772015PubMed
39,585,047Comparison of Three Computational Tools for the Prediction of RNA Tertiary Structures.Noncoding RNA2024https://conductscience.org/library/papers/39585047PubMed
39,114,355Efflux ABC transporters in drug disposition and their posttranscriptional gene regulation by microRNAs.Front Pharmacol2024https://conductscience.org/library/papers/39114355PubMed
38,472,371Essential factors, advanced strategies, challenges, and approaches involved for efficient expression of recombinant proteins in Escherichia coli.Arch Microbiol2024https://conductscience.org/library/papers/38472371PubMed
37,930,837INTEDE 2.0: the metabolic roadmap of drugs.Nucleic Acids Res2024https://conductscience.org/library/papers/37930837PubMed
37,819,041VARIDT 3.0: the phenotypic and regulatory variability of drug transporter.Nucleic Acids Res2024https://conductscience.org/library/papers/37819041PubMed
37,696,583Targeting the Liver with Nucleic Acid Therapeutics for the Treatment of Systemic Diseases of Liver Origin.Pharmacol Rev2023https://conductscience.org/library/papers/37696583PubMed

Genes27

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ABCC14,363PubTator's text mininghttps://conductscience.org/library/genes/4363NCBI Gene
ABCC38,714PubTator's text mininghttps://conductscience.org/library/genes/8714NCBI Gene
ABCC410,257PubTator's text mininghttps://conductscience.org/library/genes/10257NCBI Gene
ABCC510,057PubTator's text mininghttps://conductscience.org/library/genes/10057NCBI Gene
ABCG29,429PubTator's text mininghttps://conductscience.org/library/genes/9429NCBI Gene
CYP17A11,586PubTator's text mininghttps://conductscience.org/library/genes/1586NCBI Gene
CYP19A11,588PubTator's text mininghttps://conductscience.org/library/genes/1588NCBI Gene
CYP20A157,404PubTator's text mininghttps://conductscience.org/library/genes/57404NCBI Gene
CYP21A21,589PubTator's text mininghttps://conductscience.org/library/genes/1589NCBI Gene
CYP2B61,555PubTator's text mininghttps://conductscience.org/library/genes/1555NCBI Gene
CYP2C191,557PubTator's text mininghttps://conductscience.org/library/genes/1557NCBI Gene
CYP2C81,558PubTator's text mininghttps://conductscience.org/library/genes/1558NCBI Gene
CYP2C91,559PubTator's text mininghttps://conductscience.org/library/genes/1559NCBI Gene
CYP2D61,565PubTator's text mininghttps://conductscience.org/library/genes/1565NCBI Gene
CYP2E11,571PubTator's text mininghttps://conductscience.org/library/genes/1571NCBI Gene
CYP3A41,576PubTator's text mininghttps://conductscience.org/library/genes/1576NCBI Gene
CYP3A71,551PubTator's text mininghttps://conductscience.org/library/genes/1551NCBI Gene
CYP51A11,595PubTator's text mininghttps://conductscience.org/library/genes/1595NCBI Gene
INS3,630PubTator's text mininghttps://conductscience.org/library/genes/3630NCBI Gene
MIR124-3406,909PubTator's text mininghttps://conductscience.org/library/genes/406909NCBI Gene

See all 27 genes

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Trials
  • Comments and corrections
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/36948592

GET https://conductscience.org/api/papers/v1/36948592/references?page=2

API referenceFor AI assistants