Paper · 42294061

Signaling pathway mechanisms in pancreatic ductal adenocarcinoma tumor microenvironment and emerging targeting strategies for improved prognosis.

Akinsipe T and 7 others. Oncol Rev, 2026. Cited by 0 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Signaling pathway mechanisms in pancreatic ductal adenocarcinoma tumor microenvironment and emerging targeting strategies for improved prognosis. Papers, record 42294061. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42294061

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Signaling pathway mechanisms in pancreatic ductal adenocarcinoma tumor microenvironment and emerging targeting strategies for improved prognosis.; PubMed
Journal: Oncol Rev; PubMed
Year: 2026; PubMed
Publication types: Journal Article, Systematic Review; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/42294061/; PubMed
DOI: https://doi.org/10.3389/or.2026.1814540; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC13260488/; PubMed
The journal: https://conductscience.org/library/journal-index/101519906; PubMed
Citations, by iCite: 0; iCite
Revised in PubMed: 2026-09-26; PubMed

Authors8

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Akinsipe T	Tosin
2	Odewumi CO	Caroline O
3	Latinwo L	Lekan
4	Aghimien OO	Omorose O
5	Musa MA	Musiliyu A
6	Igbinoba PO	Philip O
7	Simons AL	Anthony L
8	Aghimien MO	Monica O

Source PubMed

Topics0

NLM's MeSH indexing of the paper, its major topics first.

None in this release.

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References293

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	30,946,582	Self-Assembling ELR-Based Nanoparticles as Smart Drug-Delivery Systems Modulating Cellular Growth via Akt.	Biomacromolecules	2019	https://conductscience.org/library/papers/30946582	PubMed
2	22,500,124	Hedgehog pathway as a drug target: Smoothened inhibitors in development.	Onco Targets Ther	2012	https://conductscience.org/library/papers/22500124	PubMed
3	20,630,061	Inhibition of the mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: results of two phase II studies.	BMC Cancer	2010	https://conductscience.org/library/papers/20630061	PubMed
4	39,735,733	Challenges and Opportunities in Targeting the Complex Pancreatic Tumor Microenvironment.	JCO Oncol Adv	2024	https://conductscience.org/library/papers/39735733	PubMed
5	28,837,958	Terminating the criminal collaboration in pancreatic cancer: Nanoparticle-based synergistic therapy for overcoming fibroblast-induced drug resistance.	Biomaterials	2017	https://conductscience.org/library/papers/28837958	PubMed
6	35,967,289	Membrane-camouflaged supramolecular nanoparticles for co-delivery of chemotherapeutic and molecular-targeted drugs with siRNA against patient-derived pancreatic carcinoma.	Acta Pharm Sin B	2022	https://conductscience.org/library/papers/35967289	PubMed
7	16,413,470	ERK-MAPK signaling opposes Rho-kinase to promote endothelial cell survival and sprouting during angiogenesis.	Cancer Cell	2006	https://conductscience.org/library/papers/16413470	PubMed
8	22,995,914	CXCL12/CXCR4 protein signaling axis induces sonic hedgehog expression in pancreatic cancer cells via extracellular regulated kinase- and Akt kinase-mediated activation of nuclear factor κB: implications for bidirectional tumor-stromal interactions.	J Biol Chem	2012	https://conductscience.org/library/papers/22995914	PubMed
9	34,320,785	Phase I/II clinical trial of temsirolimus and lenalidomide in patients with relapsed and refractory lymphomas.	Haematologica	2022	https://conductscience.org/library/papers/34320785	PubMed
10	30,833,752	Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer.	Nat Med	2019	https://conductscience.org/library/papers/30833752	PubMed

1 to 10 of 293

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Cited by1

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 0 citations.

PMID	Title	Journal	Year	In Papers
42,980,888	Advancing CLDN18.2-Targeted Therapies in Pancreatic Cancer: Current Clinical Development and Therapeutic Opportunities.	Curr Treat Options Oncol	2026	https://conductscience.org/library/papers/42980888

Source PubMed

Genes12

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
AKT1	207	PubTator's text mining	https://conductscience.org/library/genes/207	NCBI Gene
CXCL12	6,387	PubTator's text mining	https://conductscience.org/library/genes/6387	NCBI Gene
CXCR4	7,852	PubTator's text mining	https://conductscience.org/library/genes/7852	NCBI Gene
IL6	3,569	PubTator's text mining	https://conductscience.org/library/genes/3569	NCBI Gene
KRAS	3,845	PubTator's text mining	https://conductscience.org/library/genes/3845	NCBI Gene
MAPK1	5,594	PubTator's text mining	https://conductscience.org/library/genes/5594	NCBI Gene
MTOR	2,475	PubTator's text mining	https://conductscience.org/library/genes/2475	NCBI Gene
NFKB1	4,790	PubTator's text mining	https://conductscience.org/library/genes/4790	NCBI Gene
PIK3CB	5,291	PubTator's text mining	https://conductscience.org/library/genes/5291	NCBI Gene
STAT3	6,774	PubTator's text mining	https://conductscience.org/library/genes/6774	NCBI Gene

1 to 10 of 12

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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