Disease · EFO_1001792

femoral neck fracture

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. femoral neck fracture. Diseases, record EFO_1001792. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/EFO_1001792

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: femoral neck fracture; Open Targets
Open Targets ID: EFO_1001792; Open Targets
Other names: Femoral Neck Fractures, fracture of neck of femur; Open Targets
MeSH: D005265; MeSH
Highest stage of its drugs: Phase 3, for 3 of its 7 drugs, from ClinicalTrials.gov; Open Targets

Drugs7

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
TRANEXAMIC ACID	CHEMBL877	Small molecule	Phase 3	ClinicalTrials.gov	3	3	3	Drugs and targets
TERIPARATIDE	CHEMBL525610	Protein	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
ERGOCALCIFEROL	CHEMBL1536	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
BUPIVACAINE	CHEMBL1098	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
BUPIVACAINE HYDROCHLORIDE	CHEMBL1200396	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
ISOFLURANE	CHEMBL1256	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
PHYTONADIONE	CHEMBL1550	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets

Targets27

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
SCN4A	Sodium channel protein type 4 subunit alpha	2	Sodium channel protein type IV alpha subunit blocker	Unknown	https://conductscience.org/library/genes/6329	Drugs and targets
GABRA1	GABA-A receptor; anion channel	1	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2554	Drugs and targets
GABRA2	GABA-A receptor; anion channel	1	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2555	Drugs and targets
GABRA3	GABA-A receptor; anion channel	1	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2556	Drugs and targets
GABRA4	GABA-A receptor; anion channel	1	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2557	Drugs and targets
GABRA5	GABA-A receptor; anion channel	1	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2558	Drugs and targets
GABRA6	GABA-A receptor; anion channel	1	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2559	Drugs and targets
GABRB1	GABA-A receptor; anion channel	1	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2560	Drugs and targets
GABRB2	GABA-A receptor; anion channel	1	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2561	Drugs and targets
GABRB3	GABA-A receptor; anion channel	1	GABA-A receptor; anion channel positive allosteric modulator	Unknown	https://conductscience.org/library/genes/2562	Drugs and targets

1 to 10 of 27

See all 27 targets

Trials9

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT01473589	Effect of Teriparatide on Hip Fracture Healing	Phase 3	122	2014-11-17	Femur Neck Fracture	TERIPARATIDE	Its record names the disease	ClinicalTrials.gov
NCT01908751	Fixation Using Alternative Implants for the Treatment of Hip Fractures (FAITH-2)	Phase 3	91	2020-11-30	Femoral Neck Fractures	ERGOCALCIFEROL	Its record names the disease	ClinicalTrials.gov
NCT01473602	Second Study of the Effect of Teriparatide on Hip Fracture Healing	Phase 3	39	2014-11-17	Femur Neck Fracture	TERIPARATIDE	Its record names the disease	ClinicalTrials.gov
NCT04488367	Blood Loss After Early TXA in Hip Fractures.	Early phase 1	120		Hip Fractures	TRANEXAMIC ACID	Its record names the disease	ClinicalTrials.gov
NCT06625606	Continuous Versus Single-Shot Spinal Anesthesia for Orthopedic Surgery	Not applicable	105		Post Operative Pain	BUPIVACAINE, ISOFLURANE	Open Targets' reading of its record	ClinicalTrials.gov
NCT06289478	Efficacy and Safety of Topical Tranexamic Acid (TXA) Administration Cementless Bipolar Hemiarthroplasty for Femoral Neck Fracture - a Randomized Controlled Trial	Not applicable	75		Femoral Neck Fracture	TRANEXAMIC ACID	Its record names the disease	ClinicalTrials.gov
NCT05095025	PENG: an Estimation of ED50 in Neck of Femur Fracture	Not applicable	50		Hip Fractures, Pain, Acute	BUPIVACAINE HYDROCHLORIDE	Open Targets' reading of its record	ClinicalTrials.gov
NCT01727843	Topical Application of Tranexamic Acid and Postoperative Blood Loss in Femoral Neck Fractures	Phase 3	15		Femoral Neck Fracture	TRANEXAMIC ACID	Its record names the disease	ClinicalTrials.gov
NCT00905229	Comparing Different Routes and Doses of Phytonadione (Vitamin K) for Reversing Warfarin Treated Patients With Hip Fracture Before Surgery	Not applicable	0		Bleeding, Complications	PHYTONADIONE	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials1

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it
31161044	DERIVED	1

Source PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/EFO_1001792

GET https://conductscience.org/api/diseases/v1/EFO_1001792/targets?page=2

API reference For AI assistants