Disease · HP_0000027

Azoospermia

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. Azoospermia. Diseases, record HP_0000027. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/HP_0000027

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: Azoospermia
Open Targets ID: HP_0000027
Other names: Absent sperm in semen
Highest stage of its drugs: Phase 3, for 4 of its 11 drugs, from ClinicalTrials.gov

Source Open Targets

Drugs11

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
GONADOTROPIN, CHORIONIC	CHEMBL1201509	Protein	Phase 3	ClinicalTrials.gov	3	3	1	Drugs and targets
CHORIOGONADOTROPIN ALFA	CHEMBL1201464	Protein	Phase 3	ClinicalTrials.gov	2	2	0	Drugs and targets
LETROZOLE	CHEMBL1444	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
CORIFOLLITROPIN ALFA	CHEMBL2108185	Protein	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
ISOTRETINOIN	CHEMBL547	Small molecule	Phase 2	ClinicalTrials.gov and TTD	3	2	2	Drugs and targets
ACYLINE	CHEMBL262747	Protein	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
DUTASTERIDE	CHEMBL1200969	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
KETOCONAZOLE	CHEMBL157101	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
TESTOSTERONE	CHEMBL386630	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
DENOSUMAB	CHEMBL1237023	Antibody	Phase 1/2	ClinicalTrials.gov	1	1	1	Drugs and targets

1 to 10 of 11

See all 11 drugs

Targets13

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
LHCGR	Lutropin-choriogonadotropic hormone receptor	2	Luteinizing hormone/Choriogonadotropin receptor agonist	Phase 3	https://conductscience.org/library/genes/3973	Drugs and targets
AR	Androgen receptor	1	Androgen Receptor agonist	Phase 2	https://conductscience.org/library/genes/367	Drugs and targets
CYP19A1	Aromatase	1	Cytochrome P450 19A1 inhibitor	Phase 3	https://conductscience.org/library/genes/1588	Drugs and targets
ESR1	Estrogen receptor	1	Estrogen receptor alpha modulator	Unknown	https://conductscience.org/library/genes/2099	Drugs and targets
FSHR	Follicle-stimulating hormone receptor	1	Follicle stimulating hormone receptor agonist	Phase 3	https://conductscience.org/library/genes/2492	Drugs and targets
GNRHR	Gonadotropin-releasing hormone receptor	1	Gonadotropin-releasing hormone receptor antagonist	Phase 2	https://conductscience.org/library/genes/2798	Drugs and targets
RARA	Retinoic acid receptor	1	Retinoic acid receptor agonist	Phase 2	https://conductscience.org/library/genes/5914	Drugs and targets
RARB	Retinoic acid receptor	1	Retinoic acid receptor agonist	Phase 2	https://conductscience.org/library/genes/5915	Drugs and targets
RARG	Retinoic acid receptor	1	Retinoic acid receptor agonist	Phase 2	https://conductscience.org/library/genes/5916	Drugs and targets
SRD5A1	Steroid 5-alpha-reductase	1	Steroid 5-alpha-reductase inhibitor	Phase 2	https://conductscience.org/library/genes/6715	Drugs and targets

1 to 10 of 13

See all 13 targets

Trials7

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT01709331	A Study of the Efficacy and Safety of Corifollitropin Alfa (MK-8962) in Combination With Human Chorionic Gonadotropin (hCG) in Adult Men With Hypogonadotropic Hypogonadism (HH) (P07937)	Phase 3	18	2016-05-09	Hypogonadism, Hypogonadotropic Hypogonadism	CORIFOLLITROPIN ALFA, GONADOTROPIN, CHORIONIC	Its record names the disease	ClinicalTrials.gov
NCT03323801	RA-4: 13-cis Retinoic Acid for Treatment of Men With Azoospermia	Phase 2	10	2021-10-26	Male Infertility, Azoospermia	ISOTRETINOIN	Its record names the disease	ClinicalTrials.gov
NCT07481370	Isotretinoin vs hCG for Male Infertility Due to Low or Absent Sperm	Phase 2	100		Oligospermia, Azoospermia, Nonobstructive, Infertility	ISOTRETINOIN	Its record names the disease	ClinicalTrials.gov
NCT02900105	Effect of Letrozole on Seminal Parameters in Men With Non Obstructive Azoospermia and Severe Oligozoospermia.	Phase 3	28		Azoospermia, Nonobstructive, Oligozoospermia	LETROZOLE	Its record names the disease	ClinicalTrials.gov
NCT06706414	NT-NOA - Novel Treatment of Some Men With Non-Obstructive Azoospermia	Phase 1/2	16		Infertility, Male	DENOSUMAB, LETROZOLE	Its record names the disease	ClinicalTrials.gov
NCT02137265	Assessing the Efficacy of Clomiphene Citrate in Patients With Azoospermia and Hypoandrogenism	Not applicable	0		Non Obstructive Azoospermia, Hypogonadism	CLOMIPHENE CITRATE	Its record names the disease	ClinicalTrials.gov
NCT02147964	ITT-5 Mechanisms of Spermatogenesis in Man	Phase 2	0		Gonadotropin Deficiency	ACYLINE, DUTASTERIDE, KETOCONAZOLE, TESTOSTERONE	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials3

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
28270212	RESULT	1	PubMed
22958644	RESULT	1	PubMed
16291975	RESULT	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/HP_0000027

GET https://conductscience.org/api/diseases/v1/HP_0000027/drugs

API reference For AI assistants