Disease · HP_0000791
Uric acid nephrolithiasis
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. Uric acid nephrolithiasis. Diseases, record HP_0000791. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/HP_0000791
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
- Name
- Uric acid nephrolithiasis
- Open Targets ID
- HP_0000791
- Other names
- Uric acid stones, Uric acid urolithiasis
- Highest stage of its drugs
- Phase 2, for 2 of its 8 drugs, from ClinicalTrials.gov
Source Open Targets
Drugs8
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| PHENTERMINE | CHEMBL1574 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| TOPIRAMATE | CHEMBL220492 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| POTASSIUM BICARBONATE | CHEMBL2106975 | Small molecule | Early phase 1 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| POTASSIUM CITRATE | CHEMBL3989822 | Small molecule | Early phase 1 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| SODIUM BICARBONATE | CHEMBL1353 | Small molecule | Early phase 1 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| FEBUXOSTAT | CHEMBL1164729 | Small molecule | Unknown | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| PIOGLITAZONE | CHEMBL595 | Small molecule | Unknown | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| POTASSIUM SODIUM HYDROGEN CITRATE | CHEMBL6068001 | Small molecule | Unknown | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
Targets40
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| CA2 | Carbonic anhydrase 2 | 1 | Carbonic anhydrase II inhibitor | Phase 2 | https://conductscience.org/library/genes/760 | Drugs and targets |
| CA4 | Carbonic anhydrase 4 | 1 | Carbonic anhydrase IV inhibitor | Phase 2 | https://conductscience.org/library/genes/762 | Drugs and targets |
| GABRA1 | GABA-A receptor; anion channel | 1 | GABA-A receptor; anion channel positive modulator | Phase 2 | https://conductscience.org/library/genes/2554 | Drugs and targets |
| GABRA2 | GABA-A receptor; anion channel | 1 | GABA-A receptor; anion channel positive modulator | Phase 2 | https://conductscience.org/library/genes/2555 | Drugs and targets |
| GABRA3 | GABA-A receptor; anion channel | 1 | GABA-A receptor; anion channel positive modulator | Phase 2 | https://conductscience.org/library/genes/2556 | Drugs and targets |
| GABRA4 | GABA-A receptor; anion channel | 1 | GABA-A receptor; anion channel positive modulator | Phase 2 | https://conductscience.org/library/genes/2557 | Drugs and targets |
| GABRA5 | GABA-A receptor; anion channel | 1 | GABA-A receptor; anion channel positive modulator | Phase 2 | https://conductscience.org/library/genes/2558 | Drugs and targets |
| GABRA6 | GABA-A receptor; anion channel | 1 | GABA-A receptor; anion channel positive modulator | Phase 2 | https://conductscience.org/library/genes/2559 | Drugs and targets |
| GABRB1 | GABA-A receptor; anion channel | 1 | GABA-A receptor; anion channel positive modulator | Phase 2 | https://conductscience.org/library/genes/2560 | Drugs and targets |
| GABRB2 | GABA-A receptor; anion channel | 1 | GABA-A receptor; anion channel positive modulator | Phase 2 | https://conductscience.org/library/genes/2561 | Drugs and targets |
1 to 10 of 40
See all 40 targetsTrials4
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT04621929 | Phentermine/Topiramate for Uric Acid Stones | Phase 2 | 19 | 2026-01-30 | Obesity, Uric Acid Stones, Type 2 Diabetes Mellitus in Obese, Pre-Diabetes | PHENTERMINE, TOPIRAMATE | Its record names the disease | ClinicalTrials.gov |
| NCT00904046 | Pathophysiology of Uric Acid Nephrolithiasis | Not applicable | 172 | Uric Acid Kidney Stone Disease | PIOGLITAZONE | Its record names the disease | ClinicalTrials.gov | |
| NCT04352153 | Role of Uralyt-U in Patients With Hyperuricemia | Not applicable | 102 | Uric Acid Stones, Hyperuricemia | FEBUXOSTAT, POTASSIUM SODIUM HYDROGEN CITRATE | Its record names the disease | ClinicalTrials.gov | |
| NCT04651088 | Comparing Alkalinizing Agents Efficacy on Stone Risk in Patients on a Metabolically Controlled Diet | Early phase 1 | 15 | Kidney Stone | POTASSIUM BICARBONATE, POTASSIUM CITRATE, SODIUM BICARBONATE | Its record names the disease | ClinicalTrials.gov |
Comparisons in its trials2
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| Allocated to Intervention/Treatment vs Allocated to Pragmatic Control: deaths from any cause | 0 of 13 | 0 of 6 | 19 | NCT04621929 | Trial comparisons |
| Allocated to Intervention/Treatment vs Allocated to Pragmatic Control: serious adverse events | 0 of 13 | 0 of 6 | 19 | NCT04621929 | Trial comparisons |
Papers from its trials1
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
| PMID | Listed as | Trials listing it |
|---|---|---|
| 36261757 | DERIVED | 1 |
Source PubMed
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/HP_0000791
GET https://conductscience.org/api/diseases/v1/HP_0000791/targets?page=2