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Disease · HP_0001945

Fever

6 sourcesdiseases-2026-09-18-0.1.0

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ConductScience Library. Fever. Diseases, record HP_0001945. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/HP_0001945

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name
Fever
Open Targets
Open Targets ID
HP_0001945
Open Targets
Other names
Hyperthermia, Pyrexia
Open Targets
NCI Thesaurus
C3038
NCI Thesaurus
Highest stage of its drugs
Approval, for 50 of its 125 drugs, from ATC, DailyMed, PMDA and TTD
Open Targets

Drugs125

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

DrugChEMBL IDTypeOpen Targets' stageStage reported byReportsOf them trialsTrials shown hereSource
ACETAMINOPHENCHEMBL112Small moleculeApprovalATC, DailyMed and PMDA671818Drugs and targets
IBUPROFENCHEMBL521Small moleculeApprovalDailyMed241616Drugs and targets
DIPYRONECHEMBL3989803Small moleculeApprovalATC411Drugs and targets
DANTROLENECHEMBL1201288Small moleculeApprovalTTD211Drugs and targets
DEXTROMETHORPHAN HYDROBROMIDECHEMBL1256818Small moleculeApprovalDailyMed3300Drugs and targets
PHENYLEPHRINE HYDROCHLORIDECHEMBL1200339Small moleculeApprovalDailyMed2100Drugs and targets
GUAIFENESINCHEMBL980Small moleculeApprovalDailyMed1600Drugs and targets
ASPIRINCHEMBL25Small moleculeApprovalATC and DailyMed1000Drugs and targets
AMINOPYRINECHEMBL288470Small moleculeApprovalATC300Drugs and targets
ANTIPYRINECHEMBL277474Small moleculeApprovalATC300Drugs and targets

1 to 10 of 125

See all 125 drugs

Targets61

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

TargetProteinIts drugs that act on itMechanismsHighest stage of those drugsGene in GenesSource
PTGS1Cyclooxygenase13Cyclooxygenase inhibitor; Cyclooxygenase-1 inhibitorApprovalhttps://conductscience.org/library/genes/5742Drugs and targets
PTGS2Cyclooxygenase12Cyclooxygenase inhibitorApprovalhttps://conductscience.org/library/genes/5743Drugs and targets
HRH1Histamine H1 receptor4Histamine H1 receptor antagonistApprovalhttps://conductscience.org/library/genes/3269Drugs and targets
RYR1Ryanodine receptor 12Ryanodine receptor 1 antagonistApprovalhttps://conductscience.org/library/genes/6261Drugs and targets
RYR3Ryanodine receptor 32Ryanodine receptor 3 antagonistApprovalhttps://conductscience.org/library/genes/6263Drugs and targets
SLC6A2Sodium-dependent noradrenaline transporter2Norepinephrine transporter inhibitor; Norepinephrine transporter releasing agentApprovalhttps://conductscience.org/library/genes/6530Drugs and targets
TNFTumor necrosis factor2TNF-alpha inhibitorPhase 3https://conductscience.org/library/genes/7124Drugs and targets
TOP1DNA topoisomerase 12DNA topoisomerase I inhibitorPhase 2https://conductscience.org/library/genes/7150Drugs and targets
TOP2ADNA topoisomerase 2-alpha2DNA topoisomerase II alpha inhibitor; DNA topoisomerase II inhibitorPhase 2https://conductscience.org/library/genes/7153Drugs and targets
ADRA1AAdrenergic receptor alpha-11Adrenergic receptor alpha-1 agonistApprovalhttps://conductscience.org/library/genes/148Drugs and targets

1 to 10 of 61

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Trials81

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 2 more are not shown, since the checks do not confirm them.

TrialTitlePhaseParticipantsResults first postedConditionsDrugsLinked bySource
NCT00598559Safety and Efficacy of Intravenous Acetaminophen (IV APAP) in Adult InpatientsPhase 32132010-12-10Acute Pain, FeverACETAMINOPHENIts record names the diseaseClinicalTrials.gov
NCT00841789A Randomized, Double Blind, Placebo Controlled Study of Etanercept in Children With Kawasaki DiseasePhase 22052023-05-06Mucocutaneous Lymph Node Syndrome, Kawasaki DiseaseETANERCEPTIts record names the diseaseClinicalTrials.gov
NCT01021683The Relationship of Defeverscence and Itraconazole Plasma Level Study in Immunocompromised Participants2032013-07-03Hematologic Neoplasms, Neutropenia, FeverITRACONAZOLEIts record names the diseaseClinicalTrials.gov
NCT00889863Flare Prevention Study of Canakinumab in Patients With Active Systemic Juvenile Idiopathic Arthritis (SJIA)Phase 31772012-10-16Systemic Juvenile Idiopathic Arthritis With Active FlareCANAKINUMABIts record names the diseaseClinicalTrials.gov
NCT01334944Surveillance Trial to Evaluate a Shortened Infusion Time of Intravenous IbuprofenPhase 41502014-06-23Pain, FeverIBUPROFENIts record names the diseaseClinicalTrials.gov
NCT00150345Immediate vs. Deferred Empirical Antifungal Treatment With Voriconazole In Neutropenic PatientsPhase 31472010-08-18Possible Fungal InfectionVORICONAZOLEIts record names the diseaseClinicalTrials.gov
NCT01002573Safety, Efficacy, and Pharmacokinetic Study of Intravenous Ibuprofen in Pediatric PatientsPhase 31182016-11-07FeverACETAMINOPHEN, IBUPROFENIts record names the diseaseClinicalTrials.gov
NCT00564629Study of the Efficacy and Safety of Intravenous vs Oral Acetaminophen for Treatment of Fever in Healthy Adult MalesPhase 31052010-09-21FeverACETAMINOPHENIts record names the diseaseClinicalTrials.gov
NCT03065244KIDCARE (Kawasaki Disease Comparative Effectiveness Trial)Phase 31052021-12-03Mucocutaneous Lymph Node SyndromeINFLIXIMABIts record names the diseaseClinicalTrials.gov
NCT00598702Study of the Safety & Efficacy of Intravenous Acetaminophen in Pediatric InpatientsPhase 31002011-01-06Pain, FeverACETAMINOPHENIts record names the diseaseClinicalTrials.gov

1 to 10 of 81

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Comparisons in its trials48

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

ComparisonGroup 1, with the outcomeGroup 2, with the outcomeParticipantsTrialSource
Arm 1 -Etanercept vs ARM 2 Placebo: Determine if Etanercept Treatment Alters the Rate of Coronary Artery Dilation and Disease (CAD) at 2 and 6 Weeks After Treatment in Patients With Dilated Coro56 of 10053 of 101201NCT00841789Trial comparisons
Arm 1 -Etanercept vs ARM 2 Placebo: IVIG Refractory13 of 10022 of 101201NCT00841789Trial comparisons
Arm 1 -Etanercept vs Arm -2 Placebo: deaths from any cause0 of 990 of 102201NCT00841789Trial comparisons
Arm 1 -Etanercept vs Arm -2 Placebo: serious adverse events9 of 9910 of 102201NCT00841789Trial comparisons
Fever vs Pain: serious adverse events0 of 111 of 139150NCT01334944Trial comparisons
Immediate Voriconazole vs Deferred Voriconazole Treatment: serious adverse events8 of 818 of 66147NCT00150345Trial comparisons
Immediate Voriconazole vs Deferred Voriconazole Treatment: Number of Participants Assessed as Needing Further Antineoplastic Therapy as Planned42 of 6832 of 54122NCT00150345Trial comparisons
Immediate Voriconazole vs Deferred Voriconazole Treatment: Number of Participants With Defervescence Day 5 (4 Days After Initiation of Study Treatment)32 of 6828 of 54122NCT00150345Trial comparisons
Oral Acetaminophen (PO APAP) 1 g vs Intravenous Acetaminophen (IV APAP) 1 g / 100 ml Solution: serious adverse events0 of 510 of 54105NCT00564629Trial comparisons
IVIG vs Infliximab: Number of Participants With IVIG and Infliximab Infusion Reactions and Complications1 of 492 of 54103NCT03065244Trial comparisons

1 to 10 of 48

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Papers from its trials36

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMIDListed asTrials listing itSource
35545881RESULT1PubMed
31048415RESULT1PubMed
30471141RESULT1PubMed
26619462RESULT1PubMed
25020130RESULT1PubMed
24618935RESULT1PubMed
22271702RESULT1PubMed
21837771RESULT1PubMed
21394050RESULT1PubMed
20431381RESULT1PubMed

1 to 10 of 36

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Data dates

The date of each source this release read.

Open Targets
2026-09-18
Open Targets
Drug links and their checks, from Drugs and targets
2026-09-18
Drugs and targets
ClinicalTrials.gov, from Trials
2026-11-12
Trials
Comparisons, from Trial comparisons
2026-03-23
Trial comparisons
PubMed, for the checks
2026-11-06
PubMed
MeSH, for the checks
2026-11-10
MeSH

Sources 6

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • NLM's MeSHNLM's terms
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • NLM's MeSHNLM's
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/HP_0001945

GET https://conductscience.org/api/diseases/v1/HP_0001945/drugs?page=2

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