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Disease · HP_0002017

Nausea and vomiting

6 sourcesdiseases-2026-09-18-0.1.0

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ConductScience Library. Nausea and vomiting. Diseases, record HP_0002017. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/HP_0002017

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name
Nausea and vomiting
Open Targets ID
HP_0002017
Highest stage of its drugs
Approval, for 24 of its 32 drugs, from DailyMed and TTD

Source Open Targets

Drugs32

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

DrugChEMBL IDTypeOpen Targets' stageStage reported byReportsOf them trialsTrials shown hereSource
PALONOSETRON HYDROCHLORIDECHEMBL1720Small moleculeApprovalDailyMed500Drugs and targets
GRANISETRONCHEMBL289469Small moleculeApprovalDailyMed and TTD400Drugs and targets
APREPITANTCHEMBL1471Small moleculeApprovalDailyMed300Drugs and targets
MECLIZINE HYDROCHLORIDECHEMBL3989555Small moleculeApprovalDailyMed300Drugs and targets
ONDANSETRONCHEMBL46Small moleculeApprovalDailyMed300Drugs and targets
ONDANSETRON HYDROCHLORIDECHEMBL3186492Small moleculeApprovalDailyMed300Drugs and targets
PROCHLORPERAZINECHEMBL728Small moleculeApprovalDailyMed300Drugs and targets
FOSAPREPITANT DIMEGLUMINECHEMBL1201782Small moleculeApprovalDailyMed200Drugs and targets
PROMETHAZINE HYDROCHLORIDECHEMBL1200750Small moleculeApprovalDailyMed200Drugs and targets
PYRIDOXINECHEMBL1364Small moleculeApprovalDailyMed200Drugs and targets

1 to 10 of 32

See all 32 drugs

Targets30

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

TargetProteinIts drugs that act on itMechanismsHighest stage of those drugsGene in GenesSource
HTR3A5-hydroxytryptamine receptor 3A9Serotonin (5-HT) receptor antagonist; Serotonin 3 (5-HT3) receptor antagonist; Serotonin 3a (5-HT3a) receptor antagonistApprovalhttps://conductscience.org/library/genes/3359Drugs and targets
DRD2D(2) dopamine receptor6D2-like dopamine receptor antagonist; Dopamine D2 receptor antagonist; Dopamine receptors; D2 & D3 antagonistApprovalhttps://conductscience.org/library/genes/1813Drugs and targets
HRH1Histamine H1 receptor4Histamine H1 receptor antagonistApprovalhttps://conductscience.org/library/genes/3269Drugs and targets
OPRM1Mu-type opioid receptor4Mu opioid receptor agonistPhase 3https://conductscience.org/library/genes/4988Drugs and targets
DRD3D2-like dopamine receptor3D2-like dopamine receptor antagonist; Dopamine receptors; D2 & D3 antagonistApprovalhttps://conductscience.org/library/genes/1814Drugs and targets
HTR2A5-hydroxytryptamine receptor 2A3Serotonin (5-HT) receptor antagonist; Serotonin 2a (5-HT2a) receptor antagonistApprovalhttps://conductscience.org/library/genes/3356Drugs and targets
CHRM1Muscarinic acetylcholine receptor M12Muscarinic acetylcholine receptor M1 antagonistApprovalhttps://conductscience.org/library/genes/1128Drugs and targets
CNR1Cannabinoid receptor 12Cannabinoid CB1 receptor agonistApprovalhttps://conductscience.org/library/genes/1268Drugs and targets
DRD4D2-like dopamine receptor2D2-like dopamine receptor antagonistApprovalhttps://conductscience.org/library/genes/1815Drugs and targets
HTR3BSerotonin (5-HT) receptor2Serotonin (5-HT) receptor antagonist; Serotonin 3 (5-HT3) receptor antagonistApprovalhttps://conductscience.org/library/genes/9177Drugs and targets

1 to 10 of 30

See all 30 targets

Trials4

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

TrialTitlePhaseParticipantsResults first postedConditionsDrugsLinked bySource
NCT00613938A Study to Evaluate the Effectiveness and Safety of Tapentadol (CG5503) in the Treatment of Acute Pain From Bunionectomy.Phase 39012010-04-23Arthralgia, Bunion, Hallux Valgus, PainOXYCODONE, TAPENTADOLIts record names the diseaseClinicalTrials.gov
NCT02223377Satisfactory Analgesia Minimal Emesis in Day SurgeriesNot applicable4022023-12-11Pain, Post Operative Nausea and VomitingHYDROMORPHONE, MORPHINEOpen Targets' reading of its recordClinicalTrials.gov
NCT00614445The Efficacy Of Diclectin® For Nausea And Vomiting Of PregnancyPhase 32802011-09-05Nausea and Vomiting of PregnancyDOXYLAMINE SUCCINATE, PYRIDOXINE HYDROCHLORIDEOpen Targets' reading of its recordClinicalTrials.gov
NCT02400047Dexamethasone, Can it Replace Ketoprofen in the Strategy of Intraoperative Multimodal Analgesia in Paediatric Surgery ? A Prospective Randomized Double-blinded Study. DEXA OPPhase 3580Postoperative Nausea and VomitingDEXAMETHASONE, KETOPROFENOpen Targets' reading of its recordClinicalTrials.gov

Comparisons in its trials8

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

ComparisonGroup 1, with the outcomeGroup 2, with the outcomeParticipantsTrialSource
Morphine vs Hydromorphone: Severe Respiratory Depression11 of 19910 of 202401NCT02223377Trial comparisons
Morphine vs Hydromorphone: Number of Patients With Severe Itching2 of 1995 of 202401NCT02223377Trial comparisons
Morphine vs Hydromorphone: Severe Sedation5 of 1998 of 202401NCT02223377Trial comparisons
Morphine vs Hydromorphone: Our Combined Primary Outcome Will be Number of Patients With Same Analgesia Minimal Emesis, as Compared Between the 2 Groups.172 of 199175 of 202401NCT02223377Trial comparisons
Morphine vs Hydromorphone: deaths from any cause0 of 1990 of 202401NCT02223377Trial comparisons
Morphine vs Hydromorphone: serious adverse events11 of 19910 of 202401NCT02223377Trial comparisons
Morphine vs Hydromorphone: Patients Requesting Oral Analgesia in the Day Surgery Unit128 of 194135 of 199393NCT02223377Trial comparisons
Diclectin® vs Placebo: serious adverse events4 of 1335 of 128261NCT00614445Trial comparisons

Papers from its trials10

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMIDListed asTrials listing itSource
31027915DERIVED1PubMed
29934395DERIVED1PubMed
29342163DERIVED1PubMed
27881103DERIVED1PubMed
26844757DERIVED1PubMed
25884778DERIVED1PubMed
25052410DERIVED1PubMed
22972538DERIVED1PubMed
20843504DERIVED1PubMed
19445652DERIVED1PubMed

Data dates

The date of each source this release read.

Open Targets
2026-09-18
Open Targets
Drug links and their checks, from Drugs and targets
2026-09-18
Drugs and targets
ClinicalTrials.gov, from Trials
2026-11-12
Trials
Comparisons, from Trial comparisons
2026-03-23
Trial comparisons
PubMed, for the checks
2026-11-06
PubMed
MeSH, for the checks
2026-11-10
MeSH

Sources 6

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • NLM's MeSHNLM's terms
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • NLM's MeSHNLM's
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/HP_0002017

GET https://conductscience.org/api/diseases/v1/HP_0002017/drugs?page=2

API referenceFor AI assistants