Disease · HP_0006536
Airway obstruction
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. Airway obstruction. Diseases, record HP_0006536. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/HP_0006536
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
Drugs77
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| ALBUTEROL | CHEMBL714 | Small molecule | Approval | ATC and DailyMed | 9 | 1 | 1 | Drugs and targets |
| MONTELUKAST | CHEMBL787 | Small molecule | Approval | ATC | 3 | 1 | 1 | Drugs and targets |
| IPRATROPIUM | CHEMBL1621597 | Small molecule | Approval | TTD | 2 | 1 | 1 | Drugs and targets |
| IPRATROPIUM BROMIDE | CHEMBL2134724 | Small molecule | Approval | ATC | 2 | 1 | 1 | Drugs and targets |
| MEPOLIZUMAB | CHEMBL2108429 | Antibody | Approval | ATC | 2 | 1 | 1 | Drugs and targets |
| ISOPROTERENOL | CHEMBL434 | Small molecule | Approval | ATC | 3 | 0 | 0 | Drugs and targets |
| TERBUTALINE | CHEMBL1760 | Small molecule | Approval | ATC | 3 | 0 | 0 | Drugs and targets |
| THEOPHYLLINE | CHEMBL1355736 | Protein | Approval | ATC | 3 | 0 | 0 | Drugs and targets |
| AMINOPHYLLINE | CHEMBL1370561 | Protein | Approval | ATC | 2 | 0 | 0 | Drugs and targets |
| CARBUTEROL | CHEMBL2110780 | Small molecule | Approval | ATC | 2 | 0 | 0 | Drugs and targets |
1 to 10 of 77
See all 77 drugsTargets55
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| ADRB2 | Adrenergic receptor | 20 | Adrenergic receptor agonist; Adrenergic receptor beta agonist; Beta-2 adrenergic receptor agonist | Approval | https://conductscience.org/library/genes/154 | Drugs and targets |
| NR3C1 | Glucocorticoid receptor | 9 | Glucocorticoid receptor agonist | Approval | https://conductscience.org/library/genes/2908 | Drugs and targets |
| CHRM3 | Muscarinic acetylcholine receptor M3 | 7 | Muscarinic acetylcholine receptor M3 antagonist | Approval | https://conductscience.org/library/genes/1131 | Drugs and targets |
| PDE4A | Phosphodiesterase 4 | 7 | Phosphodiesterase 4 inhibitor | Approval | https://conductscience.org/library/genes/5141 | Drugs and targets |
| PDE4B | Phosphodiesterase 4 | 7 | Phosphodiesterase 4 inhibitor | Approval | https://conductscience.org/library/genes/5142 | Drugs and targets |
| PDE4C | Phosphodiesterase 4 | 7 | Phosphodiesterase 4 inhibitor | Approval | https://conductscience.org/library/genes/5143 | Drugs and targets |
| PDE4D | Phosphodiesterase 4 | 7 | Phosphodiesterase 4 inhibitor | Approval | https://conductscience.org/library/genes/5144 | Drugs and targets |
| PDE3A | Phosphodiesterase 3 | 5 | Phosphodiesterase 3 inhibitor; Phosphodiesterase 3A inhibitor | Approval | https://conductscience.org/library/genes/5139 | Drugs and targets |
| ADORA1 | Adenosine receptor | 3 | Adenosine receptor antagonist | Approval | https://conductscience.org/library/genes/134 | Drugs and targets |
| ADORA2A | Adenosine receptor | 3 | Adenosine receptor antagonist | Approval | https://conductscience.org/library/genes/135 | Drugs and targets |
1 to 10 of 55
See all 55 targetsTrials8
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT01987219 | The Effects Of Bronchodilator Therapy On Respiratory And Autonomic Function In Patients With Familial Dysautonomia | Phase 3 | 15 | 2016-06-02 | Familial Dysautonomia | ALBUTEROL, IPRATROPIUM | Its record names the disease | ClinicalTrials.gov |
| NCT06936761 | This Study Evaluated the Safety of Awake Extubation in Children at Risk for Respiratory Events Undergoing General Anesthesia. | 425 | Respiratory Tract Infection | PROPOFOL, SEVOFLURANE | Its record names the disease | ClinicalTrials.gov | ||
| NCT03324490 | Thoracic Spinal Versus Epidural Anesthesia for Nephrectomy in Obstructive/Restrictive Lung Disease Patients | Not applicable | 60 | Nephrectomy, Lung Diseases, Anesthesia | BUPIVACAINE, DEXMEDETOMIDINE, FENTANYL | Its record names the disease | ClinicalTrials.gov | |
| NCT04612556 | Efficacy of Mepolizumab in Severe Asthmatics on a Long Term (MESILICO) | 45 | Asthma; Eosinophilic, Severe Asthma, Late-Onset Asthma | MEPOLIZUMAB | Its record names the disease | ClinicalTrials.gov | ||
| NCT03522402 | Effect of Head Position on MACEI of Sevoflurane in Children With Obstructive Airway | Not applicable | 38 | Sevoflurane, Endotracheal Intubation | SEVOFLURANE | Open Targets' reading of its record | ClinicalTrials.gov | |
| NCT03072849 | Early Detection and Management of Bronchiolitis Obliterans Syndrome Following Pediatric Hematopoietic Stem Cell Transplantation | 23 | Bronchiolitis Obliterans Syndrome | AZITHROMYCIN, FLUTICASONE, MONTELUKAST | Its record names the disease | ClinicalTrials.gov | ||
| NCT03119714 | Pemirolast in Allergen Challenge (PEMAG) | Phase 2 | 1 | Allergic Asthma | PEMIROLAST | Its record names the disease | ClinicalTrials.gov | |
| NCT00000568 | Lung Health Study (LHS) I and III | Phase 3 | Lung Diseases, Lung Diseases, Obstructive, Chronic Obstructive Pulmonary Disease | IPRATROPIUM BROMIDE | Open Targets' reading of its record | ClinicalTrials.gov |
Comparisons in its trials0
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
None in this release.
Papers from its trials13
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/HP_0006536
GET https://conductscience.org/api/diseases/v1/HP_0006536/drugs?page=2