Disease · MONDO_0002420

tic disorder

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. tic disorder. Diseases, record MONDO_0002420. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0002420

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: tic disorder; Open Targets
Open Targets ID: MONDO_0002420; Open Targets
Other names: Tics; Open Targets
Disease Ontology: DOID:2769; Disease Ontology
MeSH: D013981; MeSH
Highest stage of its drugs: Approval, for 2 of its 16 drugs, from DailyMed; Open Targets

Drugs16

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
PIMOZIDE	CHEMBL1423	Small molecule	Approval	DailyMed	2	1	1	Drugs and targets
HALOPERIDOL	CHEMBL54	Small molecule	Approval	DailyMed	1	0	0	Drugs and targets
NABIXIMOLS	CHEMBL3833333	Small molecule	Phase 3	ClinicalTrials.gov	2	2	1	Drugs and targets
DEUTETRABENAZINE	CHEMBL3137326	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
GUANFACINE	CHEMBL862	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
AZITHROMYCIN	CHEMBL529	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
HUMAN IMMUNOGLOBULIN G	CHEMBL1201599		Phase 2	ClinicalTrials.gov	1	1	0	Drugs and targets
PENICILLIN G	CHEMBL29	Small molecule	Phase 2	ClinicalTrials.gov	1	1	0	Drugs and targets
PENICILLIN G BENZATHINE	CHEMBL3989515	Small molecule	Phase 2	ClinicalTrials.gov	1	1	0	Drugs and targets
PENICILLIN G POTASSIUM	CHEMBL1223	Small molecule	Phase 2	ClinicalTrials.gov	1	1	0	Drugs and targets

1 to 10 of 16

See all 16 drugs

Targets13

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
DRD2	D(2) dopamine receptor	3	D2-like dopamine receptor inverse agonist; Dopamine D2 receptor partial agonist; Dopamine receptor antagonist	Approval	https://conductscience.org/library/genes/1813	Drugs and targets
HTR2A	5-hydroxytryptamine receptor 2A	3	Serotonin 2a (5-HT2a) receptor antagonist	Approval	https://conductscience.org/library/genes/3356	Drugs and targets
CNR1	Cannabinoid receptor 1	2	Cannabinoid CB1 receptor agonist; Cannabinoid CB1 receptor negative allosteric modulator	Unknown	https://conductscience.org/library/genes/1268	Drugs and targets
DRD3	D2-like dopamine receptor	2	D2-like dopamine receptor inverse agonist; Dopamine receptor antagonist	Approval	https://conductscience.org/library/genes/1814	Drugs and targets
DRD4	D2-like dopamine receptor	2	D2-like dopamine receptor inverse agonist; Dopamine receptor antagonist	Approval	https://conductscience.org/library/genes/1815	Drugs and targets
ADRA2A	Adrenergic receptor alpha-2	1	Adrenergic receptor alpha-2 agonist	Phase 3	https://conductscience.org/library/genes/150	Drugs and targets
ADRA2B	Adrenergic receptor alpha-2	1	Adrenergic receptor alpha-2 agonist	Phase 3	https://conductscience.org/library/genes/151	Drugs and targets
ADRA2C	Adrenergic receptor alpha-2	1	Adrenergic receptor alpha-2 agonist	Phase 3	https://conductscience.org/library/genes/152	Drugs and targets
DRD1	Dopamine receptor	1	Dopamine receptor antagonist	Approval	https://conductscience.org/library/genes/1812	Drugs and targets
DRD5	Dopamine receptor	1	Dopamine receptor antagonist	Approval	https://conductscience.org/library/genes/1816	Drugs and targets

1 to 10 of 13

See all 13 targets

Trials8

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 1 more is not shown, since the checks do not confirm it.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT03571256	A Study to Test if TEV-50717 is Effective in Relieving Tics Associated With Tourette Syndrome (TS)	Phase 3	158	2020-06-09	Tourette Syndrome	DEUTETRABENAZINE	Its record names the disease	ClinicalTrials.gov
NCT03087201	CANNAbinoids in the Treatment of TICS (CANNA-TICS)	Phase 3	98		Tourette Syndrome, Tic Disorders	NABIXIMOLS	Open Targets' reading, confirmed by NLM's indexing of its papers	ClinicalTrials.gov
NCT01860300	Efficacy of Amoxicilline/Clavulanic Acid in Patients Affected by Tic Disorder Colonized by Group A Streptococcus	Not applicable	46		Tic Disorders	AMOXICILLIN	Its record names the disease	ClinicalTrials.gov
NCT00004376	Phase III Randomized, Double-Blind, Placebo-Controlled Study of Guanfacine for Tourette Syndrome and Attention Deficit Hyperactivity Disorder	Phase 3	35		Tourette Syndrome	GUANFACINE	Its record names the disease	ClinicalTrials.gov
NCT00004652	Phase II Pilot Controlled Study of Short Vs Longer Term Pimozide (Orap) Therapy in Tourette Syndrome	Phase 2	20		Tourette Syndrome	PIMOZIDE	Its record names the disease	ClinicalTrials.gov
NCT01769027	Antibiotic Treatment and Intravenous Immunoglobulin Trial for PANDAS	Phase 2	0		Pandas	AZITHROMYCIN, SERTRALINE	Open Targets' reading of its record	ClinicalTrials.gov
NCT04357951	D-cycloserine Augmented Treatment for Youth With Tic Disorders	Early phase 1	0		Tourette Syndrome	CYCLOSERINE	Open Targets' reading of its record	ClinicalTrials.gov
NCT04765085	Clinical Efficacy and Change of Life Quality Through Using the Comprehensive Behavioral Intervention Treatment for Tics	Not applicable	0		Tic Disorders	ARIPIPRAZOLE	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials3

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
34708399	DERIVED	1	PubMed
34661664	DERIVED	1	PubMed
33324255	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0002420

GET https://conductscience.org/api/diseases/v1/MONDO_0002420/drugs

API reference For AI assistants