Disease · MONDO_0002508

gingivitis

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. gingivitis. Diseases, record MONDO_0002508. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0002508

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: gingivitis; Open Targets
Open Targets ID: MONDO_0002508; Open Targets
Other names: Gingival inflammation, Inflamed gums, Red and swollen gums, gingiva inflammation, inflammation of gingiva; Open Targets
Disease Ontology: DOID:3087; Disease Ontology
MeSH: D005891; MeSH
NCI Thesaurus: C34636; NCI Thesaurus
Highest stage of its drugs: Approval, for 5 of its 40 drugs, from DailyMed; Open Targets

Drugs40

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
STANNOUS FLUORIDE	CHEMBL1909079	Small molecule	Approval	DailyMed	40	29	28	Drugs and targets
CHLORHEXIDINE GLUCONATE	CHEMBL4297088	Small molecule	Approval	DailyMed	37	11	11	Drugs and targets
SODIUM FLUORIDE	CHEMBL1528	Small molecule	Approval	DailyMed	11	9	8	Drugs and targets
SODIUM MONOFLUOROPHOSPHATE	CHEMBL1908359	Small molecule	Approval	DailyMed	11	8	8	Drugs and targets
HYDROGEN PEROXIDE	CHEMBL71595	Small molecule	Approval	DailyMed	8	6	6	Drugs and targets
CHLORHEXIDINE	CHEMBL790	Small molecule	Phase 3	ClinicalTrials.gov	32	32	32	Drugs and targets
CETYLPYRIDINIUM CHLORIDE	CHEMBL2003538	Small molecule	Phase 3	ClinicalTrials.gov	14	14	14	Drugs and targets
FLUORIDE	CHEMBL1232767	Small molecule	Phase 3	ClinicalTrials.gov	14	14	14	Drugs and targets
TRICLOSAN	CHEMBL849	Small molecule	Phase 3	ClinicalTrials.gov	8	8	7	Drugs and targets
THYMOL	CHEMBL29411	Small molecule	Phase 3	ClinicalTrials.gov	6	6	1	Drugs and targets

1 to 10 of 40

See all 40 drugs

Targets6

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
AR	Androgen receptor	1	Androgen Receptor antagonist	Unknown	https://conductscience.org/library/genes/367	Drugs and targets
C3	Complement C3	1	Complement C3 inhibitor	Phase 2	https://conductscience.org/library/genes/718	Drugs and targets
ESR1	Estrogen receptor	1	Estrogen receptor alpha agonist	Unknown	https://conductscience.org/library/genes/2099	Drugs and targets
NR3C1	Glucocorticoid receptor	1	Glucocorticoid receptor antagonist	Unknown	https://conductscience.org/library/genes/2908	Drugs and targets
PGR	Progesterone receptor	1	Progesterone receptor agonist	Unknown	https://conductscience.org/library/genes/5241	Drugs and targets
VDR	Vitamin D3 receptor	1	Vitamin D receptor agonist	Phase 1	https://conductscience.org/library/genes/7421	Drugs and targets

Trials111

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 3 more are not shown, since the checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT03988374	Clinical Efficacy Evaluation of Three Dentifrices	Phase 2	319	2021-08-23	Gingival Inflammation and Bleeding, Dental Plaque	SODIUM BICARBONATE	Its record names the disease	ClinicalTrials.gov
NCT02750943	Potential of Stannous Fluoride Toothpaste to Reduce Gum Disease	Not applicable	253	2016-11-11	Gingivitis	STANNOUS FLUORIDE	Its record names the disease	ClinicalTrials.gov
NCT02207907	To Evaluate the Efficacy and Tolerability of Sodium Bicarbonate Toothpaste	Phase 2	247	2017-02-17	Oral Hygiene	SODIUM BICARBONATE, SODIUM FLUORIDE	Its record names the disease	ClinicalTrials.gov
NCT02207400	To Evaluate Efficacy and Tolerability of Sodium Bicarbonate Toothpaste and Its Effect on Opportunistic or Resistant Organisms	Phase 2	246	2016-07-26	Oral Hygiene	SODIUM BICARBONATE, SODIUM FLUORIDE	Its record names the disease	ClinicalTrials.gov
NCT06660069	A Study to Evaluate the Efficacy of a Stannous Fluoride Toothpaste With a Cetylpyridinium Chloride Mouthwash in Improving Gingival Health and Reducing Plaque Accumulation	Not applicable	199	2026-03-18	Dental Plaque, Gingivitis	CETYLPYRIDINIUM CHLORIDE, STANNOUS FLUORIDE	Its record names the disease	ClinicalTrials.gov
NCT05654662	A Clinical Study Investigating the Effects of a Dentifrice Containing 67% Sodium Bicarbonate When Used Twice Daily for 12 Weeks on Gingivitis Treatment and Plaque Removal	Not applicable	197	2025-01-13	Gingivitis, Dental Plaque	SODIUM BICARBONATE	Its record names the disease	ClinicalTrials.gov
NCT06602466	A Clinical Study Investigating the Effect of an Experimental Toothpaste Containing Stannous Fluoride in Improving Gingival Health	Not applicable	175	2026-01-22	Dental Plaque, Gingivitis	STANNOUS FLUORIDE	Its record names the disease	ClinicalTrials.gov
NCT02243046	The Clinical Investigation of a Zinc Based Toothpaste in Reducing Plaque and Gingivitis	Phase 2	162	2016-05-04	Dental Plaque and Gingivitis	TRICLOSAN	Its record names the disease	ClinicalTrials.gov
NCT06143670	A Clinical Study Investigating the Effects of a Dentifrice Containing 0.454% Stannous Fluoride on Gingivitis Treatment and Plaque Reduction When Used Twice Daily for 12 Weeks	Not applicable	159	2025-03-21	Gingivitis	SODIUM FLUORIDE, STANNOUS FLUORIDE	Its record names the disease	ClinicalTrials.gov
NCT04050722	A Clinical Study Investigating the Efficacy of a Stannous Fluoride Dentifrice in Improving Gingival Health After Twice Daily Use for 3 Weeks	Phase 4	130	2020-11-19	Gingivitis	SODIUM FLUORIDE, STANNOUS FLUORIDE	Its record names the disease	ClinicalTrials.gov

1 to 10 of 111

See all 111 trials

Comparisons in its trials18

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Stannous Fluoride vs Sodium Monofluorophosphate: serious adverse events	0 of 125	0 of 128	253	NCT02750943	Trial comparisons
Sodium Bicarbonate Dentrifice vs 0% Sodium Bicarbonate Dentrifice: serious adverse events	0 of 124	0 of 123	247	NCT02207907	Trial comparisons
Sodium Bicarbonate and Sodium Fluoride Dentifrice vs Sodium Fluoride Dentifrice: serious adverse events	0 of 123	0 of 123	246	NCT02207400	Trial comparisons
Test Product (Corsodyl Original Toothpaste) vs Reference Product (Colgate Cavity Protection Toothpaste): deaths from any cause	0 of 94	0 of 96	190	NCT05654662	Trial comparisons
Test Product (Corsodyl Original Toothpaste) vs Reference Product (Colgate Cavity Protection Toothpaste): serious adverse events	0 of 94	0 of 96	190	NCT05654662	Trial comparisons
Test Toothpaste vs Reference Toothpaste (Negative Control): deaths from any cause	0 of 78	0 of 83	161	NCT06602466	Trial comparisons
Test Toothpaste vs Reference Toothpaste (Negative Control): serious adverse events	0 of 78	0 of 83	161	NCT06602466	Trial comparisons
Test Product vs Reference Product (Negative Control): deaths from any cause	0 of 76	0 of 76	152	NCT06143670	Trial comparisons
Test Product vs Reference Product (Negative Control): serious adverse events	0 of 76	0 of 76	152	NCT06143670	Trial comparisons
Sensodyne Repair and Protect (Test Dentifrice) vs Colgate Cavity Protection (Negative Control Dentifrice): deaths from any cause	0 of 65	0 of 65	130	NCT04050722	Trial comparisons

1 to 10 of 18

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Papers from its trials33

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
41328922	RESULT	1	PubMed
39275820	RESULT	1	PubMed
39251207	RESULT	1	PubMed
38594113	RESULT	1	PubMed
35968157	RESULT	1	PubMed
35287956	RESULT	1	PubMed
34134691	RESULT	1	PubMed
26427569	RESULT	1	PubMed
25624634	RESULT	1	PubMed
25478471	RESULT	1	PubMed

1 to 10 of 33

See all 33 papers from its trials

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0002508

GET https://conductscience.org/api/diseases/v1/MONDO_0002508/drugs?page=2

API reference For AI assistants