Disease · MONDO_0004972
adenoma
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. adenoma. Diseases, record MONDO_0004972. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0004972
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
- Other names
- acinar cell adenoma, acinar cell adenoma (morphologic abnormality), acinic cell adenoma, adenomas
- Open Targets
Drugs11
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| BROMOCRIPTINE MESYLATE | CHEMBL1200503 | Small molecule | Approval | DailyMed | 1 | 0 | 0 | Drugs and targets |
| CORTICORELIN OVINE TRIFLUTATE | CHEMBL1201591 | Protein | Approval | DailyMed | 1 | 0 | 0 | Drugs and targets |
| DOCETAXEL | CHEMBL3545252 | Small molecule | Approval | EMA Human Drugs, at withdrawal | 1 | 0 | 0 | Drugs and targets |
| METHOTREXATE SODIUM | CHEMBL3244648 | Small molecule | Approval | DailyMed | 1 | 0 | 0 | Drugs and targets |
| ERLOTINIB HYDROCHLORIDE | CHEMBL1079742 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| METFORMIN | CHEMBL1431 | Small molecule | Phase 1 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| POLYETHYLENE GLYCOL | CHEMBL1201478 | Small molecule | Unknown | ClinicalTrials.gov | 2 | 2 | 1 | Drugs and targets |
| LACTULOSE | CHEMBL296306 | Small molecule | Unknown | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| PEPPERMINT OIL | CHEMBL2108758 | Unknown | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets | |
| SIMETHICONE | CHEMBL4297192 | Unknown | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
1 to 10 of 11
See all 11 drugsTargets71
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| COXFA4 | Mitochondrial complex I (NADH dehydrogenase) | 1 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | Phase 1 | https://conductscience.org/library/genes/4697 | Drugs and targets |
| COXFA4L2 | Mitochondrial complex I (NADH dehydrogenase) | 1 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | Phase 1 | https://conductscience.org/library/genes/56901 | Drugs and targets |
| DHFR | Dihydrofolate reductase | 1 | Dihydrofolate reductase inhibitor | Approval | https://conductscience.org/library/genes/1719 | Drugs and targets |
| DRD2 | D2-like dopamine receptor | 1 | D2-like dopamine receptor agonist | Approval | https://conductscience.org/library/genes/1813 | Drugs and targets |
| DRD3 | D2-like dopamine receptor | 1 | D2-like dopamine receptor agonist | Approval | https://conductscience.org/library/genes/1814 | Drugs and targets |
| DRD4 | D2-like dopamine receptor | 1 | D2-like dopamine receptor agonist | Approval | https://conductscience.org/library/genes/1815 | Drugs and targets |
| EGFR | Epidermal growth factor receptor | 1 | Epidermal growth factor receptor erbB1 inhibitor | Phase 2 | https://conductscience.org/library/genes/1956 | Drugs and targets |
| GPD2 | Glycerol-3-phosphate dehydrogenase, mitochondrial | 1 | Mitochondrial glycerol-3-phosphate dehydrogenase inhibitor | Phase 1 | https://conductscience.org/library/genes/2820 | Drugs and targets |
| MT-ND1 | Mitochondrial complex I (NADH dehydrogenase) | 1 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | Phase 1 | https://conductscience.org/library/genes/4535 | Drugs and targets |
| MT-ND2 | Mitochondrial complex I (NADH dehydrogenase) | 1 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | Phase 1 | https://conductscience.org/library/genes/4536 | Drugs and targets |
1 to 10 of 71
See all 71 targetsTrials5
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT00754494 | Erlotinib Hydrochloride in Treating Patients With Stage I-III Colorectal Cancer or Adenoma | Phase 2 | 45 | 2015-01-06 | Adenomatous Polyp, Recurrent Colon Cancer, Recurrent Rectal Cancer, Stage I Colon Cancer, Stage I Rectal Cancer, Stage IIA Colon Cancer, Stage IIA Rectal Cancer, Stage IIB Colon Cancer, Stage IIB Rectal Cancer, Stage IIC Colon Cancer, Stage IIC Rectal Cancer, Stage IIIA Colon Cancer, Stage IIIA Rectal Cancer, Stage IIIB Colon Cancer, Stage IIIB Rectal Cancer, Stage IIIC Colon Cancer, Stage IIIC Rectal Cancer | ERLOTINIB HYDROCHLORIDE | Its record names the disease | ClinicalTrials.gov |
| NCT02540239 | Premedication Simethione Improves Visibility During Bowel Cleansing for Colonoscopy | Not applicable | 590 | Bowel Preparation Scale, the Amount of Air Bubble, Adenoma Detection Rate | POLYETHYLENE GLYCOL, SIMETHICONE | Its record names the disease | ClinicalTrials.gov | |
| NCT05559814 | Intraluminal Peppermint Oil and Adenoma Detection Rate in Screening Colonoscopy | Not applicable | 404 | Colonic Polyp | PEPPERMINT OIL | Its record names the disease | ClinicalTrials.gov | |
| NCT05498714 | Improved Bowel Cleansing Method for Colonoscopy Based on High Risk Population of Bowel Preparation | Not applicable | 150 | Bowel Preparation Before Colonoscopy | LACTULOSE, SODIUM PICOSULFATE | Its record names the disease | ClinicalTrials.gov | |
| NCT01816659 | An Open-Labeled Pilot Study of Biomarker Response Following Short-Term Exposure to Metformin | Phase 1 | 3 | Colorectal Carcinoma | METFORMIN | Its record names the disease | ClinicalTrials.gov |
Comparisons in its trials0
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
None in this release.
Papers from its trials1
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
| PMID | Listed as | Trials listing it |
|---|---|---|
| 28985630 | DERIVED | 1 |
Source PubMed
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/MONDO_0004972
GET https://conductscience.org/api/diseases/v1/MONDO_0004972/targets?page=2