Disease · MONDO_0005047

infertility disorder

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. infertility disorder. Diseases, record MONDO_0005047. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0005047

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: infertility disorder; Open Targets
Open Targets ID: MONDO_0005047; Open Targets
Other names: Infertile (finding), Reproductive Sterility, Sterile, Sterility, Reproductive, fertility disorders, infertile, infertility, sterility; Open Targets
Disease Ontology: DOID:5223; Disease Ontology
MeSH: D007246; MeSH
NCI Thesaurus: C3836; NCI Thesaurus
Highest stage of its drugs: Approval, for 4 of its 44 drugs, from DailyMed, FDA and TTD; Open Targets

Drugs44

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
CLOMIPHENE CITRATE	CHEMBL3185958	Small molecule	Approval	DailyMed	14	8	8	Drugs and targets
CHORIOGONADOTROPIN ALFA	CHEMBL1201464	Protein	Approval	DailyMed	8	7	0	Drugs and targets
BROMOCRIPTINE MESYLATE	CHEMBL1200503	Small molecule	Approval	DailyMed and FDA	3	0	0	Drugs and targets
PROPIOLACTONE	CHEMBL1200627	Small molecule	Approval	TTD	1	0	0	Drugs and targets
FOLLITROPIN	CHEMBL4297955		Phase 3	ClinicalTrials.gov	15	15	14	Drugs and targets
GONADOTROPIN, CHORIONIC	CHEMBL1201509	Protein	Phase 3	ClinicalTrials.gov	12	12	4	Drugs and targets
FOLLITROPIN ALFA	CHEMBL1201692	Protein	Phase 3	ClinicalTrials.gov	11	11	11	Drugs and targets
PROGESTERONE	CHEMBL103	Small molecule	Phase 3	ClinicalTrials.gov	10	10	10	Drugs and targets
FOLLITROPIN DELTA	CHEMBL5315064	Protein	Phase 3	ClinicalTrials.gov	8	8	8	Drugs and targets
CORIFOLLITROPIN ALFA	CHEMBL2108185	Protein	Phase 3	ClinicalTrials.gov	7	7	7	Drugs and targets

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Targets80

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
FSHR	Follicle-stimulating hormone receptor	7	Follicle stimulating hormone receptor agonist	Phase 3	https://conductscience.org/library/genes/2492	Drugs and targets
GNRHR	Gonadotropin-releasing hormone receptor	7	Gonadotropin-releasing hormone receptor agonist; Gonadotropin-releasing hormone receptor antagonist	Phase 3	https://conductscience.org/library/genes/2798	Drugs and targets
LHCGR	Lutropin-choriogonadotropic hormone receptor	5	Luteinizing hormone/Choriogonadotropin receptor agonist	Approval	https://conductscience.org/library/genes/3973	Drugs and targets
DRD2	D(2) dopamine receptor	2	D2-like dopamine receptor agonist; Dopamine D2 receptor agonist	Approval	https://conductscience.org/library/genes/1813	Drugs and targets
ESR1	Estrogen receptor	2	Estrogen receptor alpha agonist; Estrogen receptor alpha modulator	Approval	https://conductscience.org/library/genes/2099	Drugs and targets
PGR	Progesterone receptor	2	Progesterone receptor agonist	Phase 3	https://conductscience.org/library/genes/5241	Drugs and targets
COXFA4	Mitochondrial complex I (NADH dehydrogenase)	1	Mitochondrial complex I (NADH dehydrogenase) inhibitor	Phase 3	https://conductscience.org/library/genes/4697	Drugs and targets
COXFA4L2	Mitochondrial complex I (NADH dehydrogenase)	1	Mitochondrial complex I (NADH dehydrogenase) inhibitor	Phase 3	https://conductscience.org/library/genes/56901	Drugs and targets
CYP19A1	Aromatase	1	Cytochrome P450 19A1 inhibitor	Phase 3	https://conductscience.org/library/genes/1588	Drugs and targets
DRD3	D2-like dopamine receptor	1	D2-like dopamine receptor agonist	Approval	https://conductscience.org/library/genes/1814	Drugs and targets

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Trials82

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 5 more are not shown, since the checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT01144416	Efficacy and Safety Study of a Single Injection of SCH 900962 Versus Daily recFSH Injections in Women Undergoing Controlled Ovarian Stimulation (Study P06029)	Phase 3	1,424	2012-12-27	Infertility	CORIFOLLITROPIN ALFA, FOLLITROPIN BETA	Its record names the disease	ClinicalTrials.gov
NCT01956110	Evidence-based Stimulation Trial With Human rFSH in Europe and Rest of World 1	Phase 3	1,329	2018-09-25	Infertility	FOLLITROPIN ALFA, FOLLITROPIN DELTA	Its record names the disease	ClinicalTrials.gov
NCT01687712	Phase III Study Comparing Efficacy and Safety of AFOLIA vs Gonal-f® RFF in Women (35 to 42) Undergoing IVF	Phase 3	1,100	2017-10-18	Infertility	FOLLITROPIN	Its record names the disease	ClinicalTrials.gov
NCT02047227	Phase 3 Study to Evaluate the Efficacy and Safety of Pergoveris® in Assisted Reproductive Technology (ESPART)	Phase 3	939	2017-01-24	Infertility	FOLLITROPIN, LUTROPIN ALFA	Its record names the disease	ClinicalTrials.gov
NCT00884221	MENOPUR in Gonadotrophin-releasing Hormone (GnRH) Antagonist Cycles With Single Embryo Transfer	Phase 3	749	2012-04-18	Infertility	FOLLITROPIN, MENOTROPINS	Its record names the disease	ClinicalTrials.gov
NCT03740737	Recombinant FSH Investigation in the Treatment of Infertility With Assisted Reproductive Technology (ART) (RITA-1)	Phase 3	579	2024-01-18	Infertility	FOLLITROPIN DELTA	Its record names the disease	ClinicalTrials.gov
NCT00505752	Investigation of a Long-Acting Follicle Stimulating Hormone in Infertile Women Undergoing Assisted Reproductive Technology (ART)	Phase 2	520	2013-07-24	Infertility	FOLLITROPIN ALFA	Its record names the disease	ClinicalTrials.gov
NCT01956123	Evidence-based Stimulation Trial With Human rFSH in Europe and Rest of World 2	Phase 3	513	2018-09-21	Infertility	FOLLITROPIN ALFA, FOLLITROPIN DELTA	Its record names the disease	ClinicalTrials.gov
NCT01121666	Multi-centre Study to Compare Efficacy and Safety of AFOLIA and Gonal-f in Women for Assisted Reproductive Treatment	Phase 3	460	2016-04-15	Infertility	FOLLITROPIN	Its record names the disease	ClinicalTrials.gov
NCT04163458	Comparison of MENOPUR Liquid and Powder in Women Undergoing Assisted Reproductive Technology (ART)	Phase 3	405	2023-11-07	Infertility	MENOTROPINS	Its record names the disease	ClinicalTrials.gov

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Comparisons in its trials38

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Single Injection of 150 µg SCH 900962/MK-8962 vs Daily 300 IU recFSH: Number of Participants Who Cancelled the Cycle Due to a (Serious) Adverse Event	5 of 692	6 of 698	1,390	NCT01144416	Trial comparisons
Single Injection of 150 µg SCH 900962/MK-8962 vs Daily 300 IU recFSH: Number of Participants With Moderate or Severe Ovarian Hyperstimulation Syndrome (OHSS)	5 of 692	10 of 698	1,390	NCT01144416	Trial comparisons
FE 999049 vs GONAL-F: serious adverse events	16 of 665	10 of 661	1,326	NCT01956110	Trial comparisons
Pergoveris vs GONAL-f: serious adverse events	8 of 462	17 of 477	939	NCT02047227	Trial comparisons
Highly Purified Menotrophin vs Recombinant FSH: serious adverse events	5 of 374	7 of 375	749	NCT00884221	Trial comparisons
FE 999049 (Follitropin Delta) vs Placebo: deaths from any cause	0 of 525	0 of 53	578	NCT03740737	Trial comparisons
FE 999049 (Follitropin Delta) vs Placebo: serious adverse events	4 of 525	0 of 53	578	NCT03740737	Trial comparisons
MENOPUR Liquid vs MENOPUR Powder: Ongoing Pregnancy Rate	91 of 202	85 of 199	401	NCT04163458	Trial comparisons
MENOPUR Liquid vs MENOPUR Powder: Positive Beta Human Chorionic Gonadotropin (βhCG) Rate	113 of 202	110 of 199	401	NCT04163458	Trial comparisons
MENOPUR Liquid vs MENOPUR Powder: Number of Participants With Potential Technical Malfunctions of the Administration Pen	1 of 202	1 of 199	401	NCT04163458	Trial comparisons

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Papers from its trials57

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
37156263	RESULT	2	PubMed
34799275	RESULT	2	PubMed
34254211	RESULT	2	PubMed
33722477	RESULT	1	PubMed
33272623	RESULT	1	PubMed
32819842	RESULT	2	PubMed
31982355	RESULT	1	PubMed
28508691	RESULT	1	PubMed
28137754	RESULT	1	PubMed
27090863	RESULT	1	PubMed

1 to 10 of 57

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Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0005047

GET https://conductscience.org/api/diseases/v1/MONDO_0005047/drugs?page=2

API reference For AI assistants