Disease · MONDO_0005275

lung disorder

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. lung disorder. Diseases, record MONDO_0005275. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0005275

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: lung disorder; Open Targets
Open Targets ID: MONDO_0005275; Open Targets
Other names: DIS PULM, Disease, Lung, Disease, Pulmonary, Diseases, Lung, Diseases, Pulmonary, LUNG DIS, Lung Diseases, PULM DIS, disease of lung, disease or disorder of lung, disorder of lung, lung disease, lung disease or disorder, lung disorders, pulmonary disease, pulmonary diseases, pulmonary disorder, pulmonary disorders; Open Targets
Disease Ontology: DOID:850; Disease Ontology
MeSH: D008171; MeSH
NCI Thesaurus: C3198; NCI Thesaurus
Highest stage of its drugs: Approval, for 12 of its 25 drugs, from DailyMed, EMA Human Drugs and TTD; Open Targets

Drugs25

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
.ALPHA.1-PROTEINASE INHIBITOR HUMAN	CHEMBL4297879	Protein	Approval	EMA Human Drugs	2	1	1	Drugs and targets
ITRACONAZOLE	CHEMBL64391	Small molecule	Approval	DailyMed	2	0	0	Drugs and targets
PIRFENIDONE	CHEMBL1256391	Small molecule	Approval	EMA Human Drugs	2	0	0	Drugs and targets
ALBUMIN HUMAN	CHEMBL1201451	Protein	Approval	DailyMed	1	0	0	Drugs and targets
AMIKACIN SULFATE	CHEMBL4208954	Small molecule	Approval	DailyMed	1	0	0	Drugs and targets
BERACTANT	CHEMBL1201624		Approval	DailyMed	1	0	0	Drugs and targets
BOVACTANT	CHEMBL2108415		Approval	TTD	1	0	0	Drugs and targets
BRENSOCATIB	CHEMBL3900409	Small molecule	Approval	EMA Human Drugs	1	0	0	Drugs and targets
CALFACTANT	CHEMBL1201447		Approval	DailyMed	1	0	0	Drugs and targets
DOXAPRAM HYDROCHLORIDE	CHEMBL3989519	Small molecule	Approval	DailyMed	1	0	0	Drugs and targets

1 to 10 of 25

See all 25 drugs

Targets17

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
NR3C1	Glucocorticoid receptor	2	Glucocorticoid receptor agonist	Phase 3	https://conductscience.org/library/genes/2908	Drugs and targets
ADORA1	Adenosine receptor	1	Adenosine receptor antagonist	Phase 2	https://conductscience.org/library/genes/134	Drugs and targets
ADORA2A	Adenosine receptor	1	Adenosine receptor antagonist	Phase 2	https://conductscience.org/library/genes/135	Drugs and targets
ADORA2B	Adenosine receptor	1	Adenosine receptor antagonist	Phase 2	https://conductscience.org/library/genes/136	Drugs and targets
ADORA3	Adenosine receptor	1	Adenosine receptor antagonist	Phase 2	https://conductscience.org/library/genes/140	Drugs and targets
CTSC	Dipeptidyl peptidase 1	1	Dipeptidyl peptidase I inhibitor	Approval	https://conductscience.org/library/genes/1075	Drugs and targets
ELANE	Neutrophil elastase	1	Leukocyte elastase inhibitor	Approval	https://conductscience.org/library/genes/1991	Drugs and targets
GUCY1A1	Soluble guanylate cyclase	1	Soluble guanylate cyclase activator	Phase 2	https://conductscience.org/library/genes/2982	Drugs and targets
GUCY1A2	Soluble guanylate cyclase	1	Soluble guanylate cyclase activator	Phase 2	https://conductscience.org/library/genes/2977	Drugs and targets
GUCY1B1	Soluble guanylate cyclase	1	Soluble guanylate cyclase activator	Phase 2	https://conductscience.org/library/genes/2983	Drugs and targets

1 to 10 of 17

See all 17 targets

Trials9

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT04356833	Nebulised Rt-PA for ARDS Due to COVID-19	Phase 2	35	2025-08-11	COVID	ALTEPLASE	Its record names the disease	ClinicalTrials.gov
NCT00004778	Phase III Randomized, Double-Blind, Placebo-Controlled Study of Antenatal Thyrotropin-Releasing Hormone in Pregnant Women With Threatened Premature Delivery	Phase 3	1,090		Respiratory Distress Syndrome	BETAMETHASONE, DEXAMETHASONE, PROTIRELIN	Its record names the disease	ClinicalTrials.gov
NCT05237505	The Cardiovascular Consequences of Sleep Apnea Plus COPD (Overlap Syndrome)	Phase 2	240		Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease, Overlap Syndrome	OXYGEN	Open Targets' reading of its record	ClinicalTrials.gov
NCT04204252	Phase III, Efficacy and Safety of "Kamada-AAT for Inhalation"	Phase 3	98		Alpha 1-Antitrypsin Deficiency	.ALPHA.1-PROTEINASE INHIBITOR HUMAN	Its record names the disease	ClinicalTrials.gov
NCT07216365	Caffeine Optimization for Oxygen Saturation Index in ELBW Infants	Phase 2	40		Neonatal Apnea, Infants	CAFFEINE CITRATE	Its record names the disease	ClinicalTrials.gov
NCT06004037	Study to Evaluate the Efficacy of Delpazolid as Add-on Therapy in Refractory Mycobacterium Abscessus Complex	Phase 2	24		Nontuberculous Mycobacterium Infection, Mycobacterium Abscessus Infection	DELPAZOLID	Its record names the disease	ClinicalTrials.gov
NCT04007120	Open-label Study of Inhaled RVT-1601 in Preterm Infants	Phase 1	8		Respiratory Morbidities of Prematurity (RMP)	CROMOLYN SODIUM	Its record names the disease	ClinicalTrials.gov
NCT03473314	Prolonged-Use of Inhaled Gaseous Nitric Oxide (gNO) for Adult With Non-Tuberculous Mycobacteria Infection	Phase 2	1		Non-Tuberculous Mycobacterial Pneumonia	NITRIC OXIDE	Its record names the disease	ClinicalTrials.gov
NCT04361461	Use of Hydroxychloroquine Alone or Associated for Inpatients With SARS-CoV2 Virus (COVID-19)	Phase 3	0		Coronavirus Infections, SARS-CoV 2, SARS (Severe Acute Respiratory Syndrome), Pulmonary Disease	AZITHROMYCIN, HYDROXYCHLOROQUINE SULFATE	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials1

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it
37665565	DERIVED	1

Source PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0005275

GET https://conductscience.org/api/diseases/v1/MONDO_0005275/drugs?page=2

API reference For AI assistants