Disease · MONDO_0005381

bone disorder

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. bone disorder. Diseases, record MONDO_0005381. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0005381

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: bone disorder; Open Targets
Open Targets ID: MONDO_0005381; Open Targets
Other names: bone disease, bone element disease, bone element disease or disorder, disease of bone element, disease or disorder of bone element, disorder of bone element; Open Targets
Disease Ontology: DOID:0080001; Disease Ontology
MeSH: D001847; MeSH
Highest stage of its drugs: Approval, for 22 of its 30 drugs, from ATC, PMDA and TTD; Open Targets

Drugs30

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
DENOSUMAB	CHEMBL1237023	Antibody	Approval	ATC	3	2	2	Drugs and targets
PAMIDRONIC ACID	CHEMBL834	Small molecule	Approval	ATC	2	1	1	Drugs and targets
ALENDRONIC ACID	CHEMBL870	Small molecule	Approval	ATC	1	0	0	Drugs and targets
ALUMINUM CHLOROHYDRATE	CHEMBL2109016		Approval	ATC	1	0	0	Drugs and targets
BUROSUMAB	CHEMBL3707326	Antibody	Approval	ATC	1	0	0	Drugs and targets
CLODRONIC ACID	CHEMBL12318	Small molecule	Approval	ATC	1	0	0	Drugs and targets
DIBOTERMIN ALFA	CHEMBL2109171	Protein	Approval	ATC	1	0	0	Drugs and targets
ELIGLUSTAT TARTRATE	CHEMBL5723563	Small molecule	Approval	PMDA	1	0	0	Drugs and targets
EPTOTERMIN ALFA	CHEMBL2108594	Protein	Approval	ATC	1	0	0	Drugs and targets
ETIDRONIC ACID	CHEMBL871	Small molecule	Approval	ATC	1	0	0	Drugs and targets

1 to 10 of 30

See all 30 drugs

Targets56

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
FDPS	Farnesyl pyrophosphate synthase	5	Farnesyl diphosphate synthase inhibitor	Approval	https://conductscience.org/library/genes/2224	Drugs and targets
ACVR1	Activin receptor type-1	2	Activin receptor type-1 agonist	Approval	https://conductscience.org/library/genes/90	Drugs and targets
BMPR1A	Bone morphogenetic protein receptor type-1A	2	Bone morphogenetic protein receptor type-1A agonist	Approval	https://conductscience.org/library/genes/657	Drugs and targets
BMPR1B	Bone morphogenetic protein receptor type-1B	2	Bone morphogenetic protein receptor type-1B agonist	Approval	https://conductscience.org/library/genes/658	Drugs and targets
BMPR2	Bone morphogenetic protein receptor type-2	2	Bone morphogenetic protein receptor type-2 agonist	Approval	https://conductscience.org/library/genes/659	Drugs and targets
FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	2	FK506-binding protein 1A inhibitor	Unknown	https://conductscience.org/library/genes/2280	Drugs and targets
ABL1	Tyrosine-protein kinase ABL1	1	Tyrosine-protein kinase ABL inhibitor	Phase 2	https://conductscience.org/library/genes/25	Drugs and targets
ACVR2A	Activin receptor type-2A	1	Activin receptor type-2A agonist	Approval	https://conductscience.org/library/genes/92	Drugs and targets
ACVR2B	Activin receptor type-2B	1	Activin receptor type-2B agonist	Approval	https://conductscience.org/library/genes/93	Drugs and targets
ADRM1	26S proteasome	1	26S proteasome inhibitor	Phase 2	https://conductscience.org/library/genes/11047	Drugs and targets

1 to 10 of 56

See all 56 targets

Trials8

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT01345019	Denosumab Compared to Zoledronic Acid in the Treatment of Bone Disease in Patients With Multiple Myeloma	Phase 3	1,718	2018-03-07	Cancer, Hematologic Malignancies, Multiple Myeloma, Oncology, Bone Metastases, Multiple Myeloma Bone Lesions	DENOSUMAB	Its record names the disease	ClinicalTrials.gov
NCT00261950	Bone Biopsy Study For Dialysis Patients With Secondary Hyperparathyroidism of End Stage Renal Disease	Phase 2	110	2013-12-04	Secondary Hyperparathyroidism	CINACALCET	Its record names the disease	ClinicalTrials.gov
NCT01062230	Bone Effect of Bortezomib in Patients With Relapsed/Refractory Multiple Myeloma	Phase 2	6	2015-04-06	Multiple Myeloma	BORTEZOMIB	Its record names the disease	ClinicalTrials.gov
NCT06314698	Narlumosbart Compared With Denosumab in Patients With Multiple Myeloma Bone Disease	Phase 3	478		Multiple Myeloma, Bone Diseases	NARLUMOSBART	Its record names the disease	ClinicalTrials.gov
NCT00591162	Bone Disease in Severely Burned Children	Phase 2/3	254		Burn	TETRACYCLINE	Its record names the disease	ClinicalTrials.gov
NCT01582295	XL184 For Relapsed/Refractory Multiple Myeloma (MM) With Bone Disease	Phase 1	4		Multiple Myeloma	CABOZANTINIB	Its record names the disease	ClinicalTrials.gov
NCT01612299	Effects of Zortress® + Tacrolimus vs. Standard Immunosuppression on Progression of Coronary Artery Calcifications and Bone Disease in de Novo Renal Transplant Recipients	Not applicable	0		Renal Transplant	EVEROLIMUS, TACROLIMUS	Its record names the disease	ClinicalTrials.gov
NCT02101164	Evaluate Time Associated With the Preparation & Administration of Denosumab/Pamidronate in Patients With Solid Tumors and Metastatic Bone Disease	Phase 4	0		Solid Tumor, Metastatic Bone Disease	DENOSUMAB, PAMIDRONIC ACID	Open Targets' reading of its record	ClinicalTrials.gov

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials0

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

None in this release.

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0005381

GET https://conductscience.org/api/diseases/v1/MONDO_0005381/drugs?page=2

API reference For AI assistants