Disease · MONDO_0005452

bulimia nervosa

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. bulimia nervosa. Diseases, record MONDO_0005452. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0005452

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: bulimia nervosa; Open Targets
Open Targets ID: MONDO_0005452; Open Targets
Other names: bulimia, hyperorexia nervosa; Open Targets
Disease Ontology: DOID:12129; Disease Ontology
MeSH: D052018; MeSH
NCI Thesaurus: C34440; NCI Thesaurus
Highest stage of its drugs: Phase 3, for 1 of its 17 drugs, from ClinicalTrials.gov; Open Targets

Drugs17

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
ACETYLCYSTEINE	CHEMBL600	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
NALTREXONE	CHEMBL19019	Small molecule	Phase 2/3	ClinicalTrials.gov	1	1	1	Drugs and targets
ACIPIMOX	CHEMBL345714	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
ERYTHROMYCIN	CHEMBL532	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
ESTRADIOL	CHEMBL135	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
LEUPROLIDE ACETATE	CHEMBL1200775	Protein	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
LISDEXAMFETAMINE DIMESYLATE	CHEMBL1201178	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
PROGESTERONE	CHEMBL103	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
MIDOMAFETAMINE	CHEMBL43048	Small molecule	Phase 1	ClinicalTrials.gov	1	1	1	Drugs and targets
PHENTERMINE	CHEMBL1574	Small molecule	Phase 1	ClinicalTrials.gov	1	1	1	Drugs and targets

1 to 10 of 17

See all 17 drugs

Targets61

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
SLC6A2	Sodium-dependent noradrenaline transporter	3	Norepinephrine transporter releasing agent; Sodium-dependent noradrenaline transporter releasing agent	Phase 2	https://conductscience.org/library/genes/6530	Drugs and targets
SLC6A3	Sodium-dependent dopamine transporter	2	Dopamine transporter releasing agent; Sodium-dependent dopamine transporter releasing agent	Phase 2	https://conductscience.org/library/genes/6531	Drugs and targets
SLC6A4	Sodium-dependent serotonin transporter	2	Serotonin transporter inhibitor; Sodium-dependent serotonin transporter releasing agent	Phase 1	https://conductscience.org/library/genes/6532	Drugs and targets
CA2	Carbonic anhydrase 2	1	Carbonic anhydrase II inhibitor	Unknown	https://conductscience.org/library/genes/760	Drugs and targets
CA4	Carbonic anhydrase 4	1	Carbonic anhydrase IV inhibitor	Unknown	https://conductscience.org/library/genes/762	Drugs and targets
DRD2	D2-like dopamine receptor	1	D2-like dopamine receptor antagonist	Unknown	https://conductscience.org/library/genes/1813	Drugs and targets
DRD3	D2-like dopamine receptor	1	D2-like dopamine receptor antagonist	Unknown	https://conductscience.org/library/genes/1814	Drugs and targets
DRD4	D2-like dopamine receptor	1	D2-like dopamine receptor antagonist	Unknown	https://conductscience.org/library/genes/1815	Drugs and targets
ESR1	Estrogen receptor	1	Estrogen receptor alpha agonist	Phase 2	https://conductscience.org/library/genes/2099	Drugs and targets
GABBR1	GABA-B receptor	1	GABA-B receptor agonist	Unknown	https://conductscience.org/library/genes/2550	Drugs and targets

1 to 10 of 61

See all 61 targets

Trials18

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT01996644	A Double Blind Clinical Trial of DCS for Food Anxiety	Not applicable	47	2018-03-27	Anorexia and Bulimia Nervosa	CYCLOSERINE	Its record names the disease	ClinicalTrials.gov
NCT00304187	Effectiveness of Antibiotic Treatment for Reducing Binge Eating and Improving Digestive Function in Bulimia Nervosa	Phase 2	29	2013-07-30	Bulimia Nervosa, Eating Disorders	ERYTHROMYCIN	Its record names the disease	ClinicalTrials.gov
NCT04225221	Neurobiology of Bulimia Nervosa	Phase 2	10	2022-07-26	Bulimia Nervosa	ESTRADIOL, LEUPROLIDE ACETATE, PROGESTERONE	Its record names the disease	ClinicalTrials.gov
NCT05073679	Oral Naltrexone In Pediatric Eating Disorders	Phase 2/3	9	2025-08-19	Anorexia Nervosa/Bulimia, Anorexia in Adolescence, Anorexia Nervosa, Atypical, Anorexia Nervosa, Binge Eating/Purging Type, Purging (Eating Disorders), Impulsive Behavior, Eating Disorders, Bulimia Nervosa, Eating Disorders in Adolescence	NALTREXONE	Its record names the disease	ClinicalTrials.gov
NCT01038128	An Open Label Trial of Memantine in the Treatment of Bulimia Nervosa and Body Dysmorphic Disorder	Not applicable	5	2012-06-12	Bulimia Nervosa, Body Dysmorphic Disorder	MEMANTINE	Its record names the disease	ClinicalTrials.gov
NCT04154813	Study on the Optimal Strategy of Chinese Patients With Bulimia Nervosa After Fluoxetine Treatment	Not applicable	550		Fluoxetine	FLUOXETINE, TOPIRAMATE	Its record names the disease	ClinicalTrials.gov
NCT00733525	Effectiveness of Stepped Care Versus Best Available Care for Bulimia Nervosa	Not applicable	293		Eating Disorders	FLUOXETINE	Its record names the disease	ClinicalTrials.gov
NCT01990755	Neurobiology of Eating Disorders Treatments	Not applicable	112		Anorexia Nervosa, Bulimia Nervosa	DELORAZEPAM, OLANZAPINE	Its record names the disease	ClinicalTrials.gov
NCT03455088	The Effect of G-DBT on the Patients With BN : A Multicenter Randomized Controlled Study	Not applicable	101		Feeding and Eating Disorders	FLUOXETINE	Its record names the disease	ClinicalTrials.gov
NCT07542145	MDMA Assisted Therapy for BN	Phase 1	40		Bulimia Nervosa	MIDOMAFETAMINE	Its record names the disease	ClinicalTrials.gov

1 to 10 of 18

See all 18 trials

Comparisons in its trials4

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Setraline vs Placebo: serious adverse events	0 of 20	0 of 16	36	NCT01996644	Trial comparisons
Erythromycin vs Placebo: serious adverse events	0 of 15	0 of 14	29	NCT00304187	Trial comparisons
Intervention vs Control: deaths from any cause	0 of 5	0 of 4	9	NCT05073679	Trial comparisons
Intervention vs Control: serious adverse events	0 of 5	1 of 4	9	NCT05073679	Trial comparisons

Papers from its trials9

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
23265409	RESULT	2	PubMed
37218020	DERIVED	1	PubMed
36167287	DERIVED	1	PubMed
33534199	DERIVED	1	PubMed
31721257	DERIVED	1	PubMed
29038069	DERIVED	1	PubMed
26132687	DERIVED	1	PubMed
25539757	DERIVED	1	PubMed
21415046	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0005452

GET https://conductscience.org/api/diseases/v1/MONDO_0005452/targets?page=2

API reference For AI assistants