Disease · MONDO_0005609

herpes zoster

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. herpes zoster. Diseases, record MONDO_0005609. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0005609

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: herpes zoster; Open Targets
Open Targets ID: MONDO_0005609; Open Targets
Other names: HZ, Zoster, shingles; Open Targets
Disease Ontology: DOID:8536; Disease Ontology
MeSH: D006562; MeSH
NCI Thesaurus: C71079; NCI Thesaurus
Highest stage of its drugs: Approval, for 6 of its 31 drugs, from DailyMed, FDA, PMDA and TTD; Open Targets

Drugs31

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
VALACYCLOVIR	CHEMBL1349	Small molecule	Approval	DailyMed	8	7	7	Drugs and targets
VALACYCLOVIR HYDROCHLORIDE	CHEMBL1201110	Small molecule	Approval	DailyMed	57	2	2	Drugs and targets
ACYCLOVIR	CHEMBL184	Small molecule	Approval	DailyMed and FDA	32	2	2	Drugs and targets
AMENAMEVIR	CHEMBL4297592	Small molecule	Approval	PMDA	3	2	2	Drugs and targets
FAMCICLOVIR	CHEMBL880	Small molecule	Approval	DailyMed and PMDA	5	1	1	Drugs and targets
VARICELLA ZOSTER VIRUS ENVELOPE GLYCOPROTEIN E	CHEMBL4297975	Vaccine component	Approval	TTD	2	1	1	Drugs and targets
ACYCLOVIR SODIUM	CHEMBL1200380	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
BUPIVACAINE	CHEMBL1098	Small molecule	Phase 3	ClinicalTrials.gov	2	2	1	Drugs and targets
INTERFERON ALFA-2B	CHEMBL1201558	Protein	Phase 3	ClinicalTrials.gov	1	1	0	Drugs and targets
METHYLPREDNISOLONE	CHEMBL650	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets

1 to 10 of 31

See all 31 drugs

Targets43

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
IFNAR1	Interferon alpha/beta receptor	3	Interferon alpha/beta receptor agonist; Interferon alpha/beta receptor positive modulator	Phase 3	https://conductscience.org/library/genes/3454	Drugs and targets
IFNAR2	Interferon alpha/beta receptor	3	Interferon alpha/beta receptor agonist; Interferon alpha/beta receptor positive modulator	Phase 3	https://conductscience.org/library/genes/3455	Drugs and targets
SCN4A	Sodium channel alpha subunit	3	Sodium channel alpha subunit blocker; Sodium channel protein type IV alpha subunit blocker	Phase 3	https://conductscience.org/library/genes/6329	Drugs and targets
CACNA2D1	Voltage-dependent calcium channel subunit alpha-2/delta-1	2	Voltage-gated calcium channel alpha2/delta subunit 1 modulator; Voltage-gated calcium channel modulator	Phase 2	https://conductscience.org/library/genes/781	Drugs and targets
CACNA2D2	Voltage-dependent calcium channel subunit alpha-2/delta-2	2	Voltage-gated calcium channel alpha2/delta subunit 2 modulator; Voltage-gated calcium channel modulator	Phase 2	https://conductscience.org/library/genes/9254	Drugs and targets
NR3C1	Glucocorticoid receptor	2	Glucocorticoid receptor agonist	Phase 3	https://conductscience.org/library/genes/2908	Drugs and targets
SCN10A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6336	Drugs and targets
SCN11A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/11280	Drugs and targets
SCN1A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6323	Drugs and targets
SCN2A	Sodium channel alpha subunit	2	Sodium channel alpha subunit blocker	Phase 2	https://conductscience.org/library/genes/6326	Drugs and targets

1 to 10 of 43

See all 43 targets

Trials27

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 3 more are not shown, since the checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT01959841	Phase III Study of ASP2151 in Herpes Zoster Patients	Phase 3	751	2018-10-18	Herpes Zoster	AMENAMEVIR, VALACYCLOVIR	Its record names the disease	ClinicalTrials.gov
NCT02590068	Effects of Chronic Viral Infection on Immune Response to Zoster Vaccination	Not applicable	14	2019-12-18	Hepatitis C	VARICELLA ZOSTER VIRUS, LIVE ATTENUATED	Its record names the disease	ClinicalTrials.gov
NCT07344246	Efficacy and Safety of Intravenous Dexamethasone Palmitate Treatments in Acute and Subacute Herpes Zoster Pain	Not applicable	954		Herpes Zoster Pain	DEXAMETHASONE	Its record names the disease	ClinicalTrials.gov
NCT07307170	The Analgesic Efficacy and Safety of Mirogabalin in Patients With Herpes Zoster	Not applicable	750		Herpes Zoster, Mirogabalin, Pain	MIROGABALIN	Its record names the disease	ClinicalTrials.gov
NCT07307976	The Analgesic Efficacy and Safety of Crisugabalin in Patients With Herpes Zoster	Not applicable	750		Herpes Zoster, Pain	CRISUGABALIN	Its record names the disease	ClinicalTrials.gov
NCT07361809	The Analgesic Efficacy and Safety of Desvenlafaxine in Patients With Herpes Zoster	Not applicable	750		Herpes Zoster, Pain	DESVENLAFAXINE	Its record names the disease	ClinicalTrials.gov
NCT07378046	The Analgesic Efficacy and Safety of Baclofen in Patients With Herpes Zoster	Not applicable	750		Herpes Zoster, Pain	BACLOFEN	Its record names the disease	ClinicalTrials.gov
NCT00487682	Dose-finding Study of ASP2151 in Subjects With Herpes Zoster	Phase 2	403		Herpes Zoster	AMENAMEVIR	Its record names the disease	ClinicalTrials.gov
NCT00002315	A Comparison of 882C87 Versus Acyclovir in the Treatment of Herpes Zoster in Patients With Weakened Immune Systems	Phase 3	400		HIV Infections, Chickenpox	ACYCLOVIR SODIUM, NETIVUDINE	Its record names the disease	ClinicalTrials.gov
NCT00831103	A Phase 2b Trial of EPB-348 for the Treatment of Herpes Zoster	Phase 2	373		Herpes Zoster	VALACYCLOVIR, VALOMACICLOVIR	Its record names the disease	ClinicalTrials.gov

1 to 10 of 27

See all 27 trials

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials7

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
36686276	RESULT	1	PubMed
29746903	RESULT	1	PubMed
22711350	RESULT	1	PubMed
38149403	DERIVED	1	PubMed
27943311	DERIVED	1	PubMed
21356040	DERIVED	1	PubMed
19469706	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0005609

GET https://conductscience.org/api/diseases/v1/MONDO_0005609/drugs?page=2

API reference For AI assistants